The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71342 | Metaterol (Metaterol) | 3571-71-9 | Metaterol is a beta-adrenergic receptor agonist (activator). |
|
V71258 | Methoxyphenamine hydrochloride (NSC-65644) | 5588-10-3 | Methoxyphenamine HCl, an analog of methamphetamine, is a beta-adrenergic receptor agonist (activator) and is used as a bronchodilator. |
|
V1135 | Methyldopa (MK-351) | 555-30-6 | Methyldopa (marketed under the brand names Aldomet; Dopamet; Dopegyt; Dopergit; Hydopa; Meldopa; Nu-Medopa; MK-351; MK 351), the methylated form of Dopa, is a potent andcompetitiveDOPA decarboxylase inhibitor with antihypertensive effects. |
|
V28602 | Metoprolol Succinate | 98418-47-4 | Metoprolol Succinate (Toprol XL)is a potent and cardioselective β1 receptor blocker medication, which is used to treat hypertension and heart failure. |
|
V1153 | Metoprolol Tartrate | 56392-17-7 | Metoprolol Tartrate (CGP2175E; CGP-2175E; Lanoc; Lopressor; Metomerck; Metop; Selopral; Ritmolol), the tartrate salt of Metoprolol, is a potent and cardioselective β1 receptor blocker with antihypertensive effects. |
|
V71308 | Metoprolol-d7 (Metoprolol d7) | 959787-96-3 | Metoprolol-d7 is the deuterium labelled form of Metoprolol. |
|
V71348 | Mibenratide | 1239011-83-6 | Mibenratide is a small cyclic peptide and an adrenergic β1 receptor blocker (antagonist). |
|
V76771 | Mibenratide TFA | Mibenratide TFA is a small cyclic peptide and an adrenergic β1 receptor antagonist. | |
|
V71249 | Midaglizole ((±)-DG5128 free base; DG5128 free base) | 66529-17-7 | Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. |
|
V71271 | Midodrine-d6 hydrochloride | 1188265-43-1 | Midodrine-d6 (HCl) is the deuterium labelled form of Midodrine. |
|
V1098 | Mirabegron (YM178) | 223673-61-8 | Mirabegron (formerly YM-178; YM178; Myrbetriq; Betanis; Betmiga) is a potent and selective β3-adrenoceptor agonist with similar effects to antimuscarinic medications. |
|
V25809 | Moxisylyte hydrochloride | 964-52-3 | Moxisylyte hydrochloride is an alpha-adrenergic blocking agent that is used in Raynauds disease. |
|
V70530 | Muscarinic toxin 3 (MT3) | 873336-87-9 | Muscarinic toxin 3 (MT3) is a potent, noncompetitive mAChR and adrenoceptors antagonist (inhibitor) with pIC50s for M1, M4, α1A, α1B, α1D, α2A, α2B and α2C receptors, respectively. |
|
V71333 | N-Methyltyramine | 370-98-9 | N-Methyltyramine is a proto-alkaloid that can be extracted from a variety of plants. |
|
V1113 | Naftopidil | 57149-07-2 | Naftopidil (BM-15275; KT611; BM15275; KT611; Flivas) is a selective α1-adrenergic receptor antagonist that has been approved for the treatment of BPH-benign prostatic hyperplasia. |
|
V1157 | Naftopidil 2HCl | 57149-08-3 | Naftopidil 2HCl (BM-15275; KT-611; BM15275; KT611; Flivas),the dihydrochloride salt of Naftopidil, is a potent and selective α1-adrenergic receptor antagonist with antihypertensive effects. |
|
V71339 | Naftopidil hydrochloride (KT-611 hydrochloride; BM-15275 hydrochloride) | 1164469-60-6 | Naftopidil HCl (KT-611 HCl) is a selective alpha1-adrenoceptor antagonist (inhibitor) with affinity Kis of 3.7 for cloned human alpha1a, alpha1b and alpha1d subtype adrenoceptors. |
|
V1117 | Naphazoline HCl | 550-99-2 | Naphazoline HCl (Albalon Liquifilm; Nafazair; Rhinantin; Vasocon),the hydrochloride salt ofNaphazoline, is animidazoline-based ocular vasoconstrictor and sympathomimetic amine used as a nasal decongestant. |
|
V1112 | Nebivolol (R 065824) | 118457-14-0 | Nebivolol (R065824; R-065824; Nobiten; Vasoxen) is a potent and selective beta1/β1-adrenoceptor antagonist with antihypertensive effects. |
|
V26343 | Nebivolol HCl (R 065824) | 152520-56-4 | Nebivolol (also known as R-65824) potently and selectively inhibits β1-adrenoceptor with IC50 of 0.8 NM. |
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