Protons can be transported across a biological membrane by the proton pump, an essential membrane protein. Mechanisms are based on the Q cycle or conformational changes in the protein structure. The proton pump uses energy during cell respiration to move protons from the mitochondrion's matrix to the intermembrane space. Due to the fact that there are more protons outside the matrix than inside, an active pump creates a gradient of proton concentration across the inner mitochondrial membrane.An electrochemical potential difference that functions similarly to a battery or energy storage unit for the cell is produced by the difference in pH and electric charge (while disregarding variations in buffer capacity). As the process generates potential energy, it can also be compared to cycling uphill or charging a battery for later use. Instead of producing energy, the proton pump creates a gradient that stores energy for later use.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V74231 | (R)-Tegoprazan ((R)-CJ-12420; (R)-RQ-00000004) | 942195-56-4 | (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole analogue, a potent gastric H+/K+-ATPase inhibitor, and a potent inhibitor of canine kidney Na+/K+-ATPase. |
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V1638 | Dexlansoprazole (R-Lansoprazole) | 138530-94-6 | Dexlansoprazole (formerly known as T168390; TAK390;Kapidex;Dexilant,R-Lansoprazole and TAK-390MR), the dextrorotatory or R-enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties byemploying a novel release formulation that prolongs its absorption. |
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V99648 | Caloxin 1C2 | Caloxin 1C2 is a specific PMCA (plasma membrane Ca2+-ATPases) inhibitor. | |
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V74232 | Caloxin 2A1 | 350670-85-8 | Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. |
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V77169 | Caloxin 2A1 TFA | Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. | |
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V35087 | Ilaprazole sodium (IY-81149 sodium) | 172152-50-0 | Ilaprazole (IY-81149) sodium, an orally bioactive proton pump inhibitor, irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparations. |
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V35088 | Ilaprazole sodium hydrate (IY-81149 sodium hydrate) | 2322264-11-7 | Ilaprazole (IY-81149) sodium hydrate, an orally bioactive proton pump inhibitor, irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparations. |
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V1683 | KPT-276 | 1421919-75-6 | KPT-276 (KPT276; KPT 276) is a potent, orally bioavailable, and selective inhibitor of CRM1 (Chromosomal Maintenance 1. |
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V74229 | Linaprazan (Linaprazan; AZD0865) | 248919-64-4 | Linaprazan (AZD0865) can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding. |
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V94749 | Nepaprazole | 156601-79-5 | Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. |
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V100031 | Padoprazanum | 2756367-23-2 | Padoprazanum (Padoprazan) is a proton pump inhibitor. |
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V1639 | PF-3716556 | 928774-43-0 | PF 3716556 (PF3716556; PF-3716556) is a novel, potent and selective P-CAB (potassium-competitive acid blocker: acid pump antagonist) with anti-acid reflux activity. |
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V87221 | Protonstatin-1 | 521972-99-6 | Protonstatin-1 is a selective plasma membrane (PM) H+-ATPase (H+-ATPase) inhibitor (IC50 of 3.9 μM) that inhibits auxin transport. |
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V87220 | Tegoprazan Benzoate | Tegoprazan Benzoate is the benzoate form of Tegoprazan. | |
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V81551 | Tegoprazan-d6 (CJ-12420-d6; RQ-00000004-d6) | Tegoprazan-d6 is a stable isotope of Tegoprazan. | |
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V74233 | Tiludronate disodium hemihydrate (Tiludronic acid disodium hemihydrate) | 155453-10-4 | Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally bioactive bisphosphonate that exerts bone modulating effects. |
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V96749 | V-ATPase-IN-1 | 1243603-61-3 | V-ATPase-IN-1 (Compound 3b-03) is a vacuolar H+-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM), which effectively targets V-ATPase subunit A (Kd = 0.803 μM). |
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V74228 | Vonoprazan Fumarate (Vonoprazan Fumarate; TAK-438) | 881681-01-2 | Vonoprazan Fumarate (TAK-438) is a proton pump inhibitor (PPI), a potent, orally bioactive potassium-competitive acid blocker (P-CAB) with anti-secretory activity . |
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V74230 | Zastaprazan (JP-1366) | 2133852-18-1 | Zastaprazan (JP-1366) is a proton pump inhibitor (WO2018008929). |
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V1632 | Lansoprazole (AG 1749) | 103577-45-3 | Lansoprazole (formerly A65006, AG1749;A-65006, AG-1749; trade name Prevacid, Zoton, Agopton, Bamalite, Opiren),a prescription and OTC drug for treatment for heartburn, is a potent and next generation proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. |