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Proton Pump

Proton Pump

Protons can be transported across a biological membrane by the proton pump, an essential membrane protein. Mechanisms are based on the Q cycle or conformational changes in the protein structure. The proton pump uses energy during cell respiration to move protons from the mitochondrion's matrix to the intermembrane space. Due to the fact that there are more protons outside the matrix than inside, an active pump creates a gradient of proton concentration across the inner mitochondrial membrane.An electrochemical potential difference that functions similarly to a battery or energy storage unit for the cell is produced by the difference in pH and electric charge (while disregarding variations in buffer capacity). As the process generates potential energy, it can also be compared to cycling uphill or charging a battery for later use. Instead of producing energy, the proton pump creates a gradient that stores energy for later use.

Proton Pump related products

Structure Cat No. Product Name CAS No. Product Description
(R)-(+)-Pantoprazole sodium V121842 (R)-(+)-Pantoprazole sodium 160098-11-3 (R)-(+)-Pantoprazole sodium is a proton pump inhibitor that can be used to study gastroesophageal reflux disease.
(R)-Tegoprazan ((R)-CJ-12420; (R)-RQ-00000004) V74231 (R)-Tegoprazan ((R)-CJ-12420; (R)-RQ-00000004) 942195-56-4 (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole analogue, a potent gastric H+/K+-ATPase inhibitor, and a potent inhibitor of canine kidney Na+/K+-ATPase.
(R)-兰索拉唑 V1638 Dexlansoprazole (R-Lansoprazole) 138530-94-6 Dexlansoprazole (formerly known as T168390; TAK390;Kapidex;Dexilant,R-Lansoprazole and TAK-390MR), the dextrorotatory or R-enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties byemploying a novel release formulation that prolongs its absorption.
2-(Trifluoromethyl)cinnamic acid V123894 2-(Trifluoromethyl)cinnamic acid 2062-25-1 2-(Trifluoromethyl)cinnamic acid is a derivative of cinnamic acid that can inhibit the proton pump (H+/K+-ATPase), thereby reducing gastric acid secretion.
4-Hydroxy omeprazole sulfide V103193 4-Hydroxy omeprazole sulfide 103876-98-8 4-Hydroxyomeprazole sulfide is a metabolite of the proton pump inhibitor omeprazole.
Apicularen B V129235 Apicularen B 220757-06-2 Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide compound that can be extracted from the myxobacterium Archangium gephyra.
Azeloprazole sodium V112094 Azeloprazole sodium 955095-47-3 Azeloprazole sodium is a potent proton pump inhibitor (PPI).
Caloxin 1C2 V99648 Caloxin 1C2 Caloxin 1C2 is a specific PMCA (plasma membrane Ca2+-ATPases) inhibitor.
Caloxin 2A1 V74232 Caloxin 2A1 350670-85-8 Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
Caloxin 2A1 TFA V77169 Caloxin 2A1 TFA Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
cis-3-Indoleacrylic acid V103707 cis-3-Indoleacrylic acid 29953-72-8 cis-3-Indoleacrylic acid is a nematicidal compound isolated from Streptomyces youssoufiensis YMF3.862.
Concanamycin D V132045 Concanamycin D 144450-34-0 Concanamycin D is a lysosomal acidification inhibitor with an IC50 value of 0.085 nM.
Concanamycin E V132046 Concanamycin E 144450-35-1 Concanamycin E is a lysosomal acidification inhibitor with an IC50 value of 0.038 nM.
Eprazole trisulfide dimer V118486 Eprazole trisulfide dimer Iprazole trisulfide dimer is the trisulfide dimer of itrapidazole, an orally effective proton pump inhibitor that irreversibly inhibits H⁺/K⁺-ATPase in a dose-dependent manner.
Esomeprazole-d3 sodium V135269 Esomeprazole-d3 sodium Esomeprazole-d3 sodium is a deuterated esomeprazole.
HV1-IN-2 V137642 HV1-IN-2 3097367-11-5 HV1-IN-2 is a human voltage-gated proton channel (HV1) inhibitor with an IC50 value of 2.14 μM.
Ilaprazole sodium (IY-81149 sodium) V35087 Ilaprazole sodium (IY-81149 sodium) 172152-50-0 Ilaprazole (IY-81149) sodium, an orally bioactive proton pump inhibitor, irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparations.
Ilaprazole sodium hydrate (IY-81149 sodium hydrate) V35088 Ilaprazole sodium hydrate (IY-81149 sodium hydrate) 2322264-11-7 Ilaprazole (IY-81149) sodium hydrate, an orally bioactive proton pump inhibitor, irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparations.
KPT-276 V1683 KPT-276 1421919-75-6 KPT-276 (KPT276; KPT 276) is a potent, orally bioavailable, and selective inhibitor of CRM1 (Chromosomal Maintenance 1.
Linaprazan (Linaprazan; AZD0865) V74229 Linaprazan (Linaprazan; AZD0865) 248919-64-4 Linaprazan (AZD0865) can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding.
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