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Integrin

Integrin

Integrins, a family of heterodimeric adhesion receptors for various extracellular matrices, have repeatedly been linked to being important initiators and promoters of ovarian cancer growth and progression. Aggressive ovarian tumors exhibit significantly elevated levels of several RGD-based integrin family members, including integrins 5-1 and v3 or v5. These adhesion receptors appear to encourage cell adhesion, survival, motility, and invasion during the development of an ovarian tumor or the spread of its metastatic disease. Notably, the activation of FAK and its downstream signaling, including the PI3K/Akt- and Ras/MAPK-dependent pathways, is crucial for the functions of these integrins.

Transmembrane proteins called integrins serve as important receptors for cell-extracellular matrix (ECM) and cell-cell adhesion.These molecules can be modified, and the v integrin family in particular, has shown to have significant effects on fibrosis in a variety of organs and disease states. According to numerous studies, the latent transforming growth factor (TGF)- is activated by the integrins v3, v5, v6, and v8 in pre-clinical fibrosis models, modulating the fibrotic process.

One of the 18 different types of subunits that are known to exist and one of the eight different types of subunits that are known to exist are typically non-covalently paired to form each integrin. There are currently 24 different heterodimers in total. The fact that the v subunit can form heterodimers with the 1, 3, 5, 6 or 8 subunits and that the 1 subunit can associate with a wide variety of subunits from 1 to 11 shows that not all theoretically possible and subunit pairs form. It's intriguing to note that a variety of v integrins appear to share a common function in TGF- activation.

Integrin related products

Structure Cat No. Product Name CAS No. Product Description
(R/S)-Alicaforsen ((R/S)-ISIS-2302) V77367 (R/S)-Alicaforsen ((R/S)-ISIS-2302) (R/S)-Alicaforsen is the racemate of Alicaforsen consisting of R and S configurations.
(S)-Deethyl-emvistegrast V122159 (S)-Deethyl-emvistegrast (S)-Deethyl-emvistegrast is the S-enantiomer of deethyl-emvistegrast.
12(S)-HETrE V102943 12(S)-HETrE 72710-10-2 12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation.
3P-RGD2 V125652 3P-RGD2 1094848-94-8 3P-RGD2 is a dimeric cyclic RGD (arginine-glycine-aspartic acid) peptide.
6-B345TTQ V103220 6-B345TTQ 297157-87-0 6-B345TTQ is an α4 integrin inhibitor that inhibits α4-Leupaxin interaction.
A-205804 V1598 A-205804 251992-66-2 A-205804 (A205804; A 205804) is a novel selective inhibitor of E-selectin and intercellular adhesion molecule-1 (ICAM-1) expression (IC50 = 20 nM and 25 nM) with potential anticancer activity.
A20FMDV2 V88814 A20FMDV2 932699-03-1 A20FMDV2 is a selective αvβ6 integrin inhibitor (IC50: 3 nM) that is 1,000-fold more active against αvβ6 than against other RGD-directed integrins (αvβ3, αvβ5, and α5β1).
A20FMDV2-Cys V127968 A20FMDV2-Cys 3107375-56-1 A20FMDV2-Cys is a 20-peptide containing cysteine that can target integrin αvβ6 with high affinity.
A286982 V3083 A286982 280749-17-9 A-286982 isa potent inhibitor of the LFA-1/ICAM-1 interaction with IC50of 44 nM in an LFA-1/ICAM-1 binding assay.
AB-3PRGD2 V128012 AB-3PRGD2 2416165-76-7 AB-3PRGD2 is a radiotherapy drug that targets integrin αvβ3.
Ac-MRGDH-NH2 V106180 Ac-MRGDH-NH2 Ac-MRGDH-NH2 is a pentapeptide containing RGD, which can be used to synthesize diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. Ac-MRGDH-NH2 can be used as a photocleavable protecting group for the cytotoxic dihydrate ruthenium warhead [Ru(Ph2phen)2(OH2)2]2+ in these prodrugs, and has integrin targeting and photosubstitutability, so it can be used in the study of tumor-targeted photoactivated chemotherapy.
Ac-RGDS-NH2 V113313 Ac-RGDS-NH2 122207-62-9 Ac-RGDS-NH2 is a tetrapeptide and belongs to the integrin antagonist class.
Adxanthromycin A V128352 Adxanthromycin A 223740-97-4 Adxanthromycin A is a microbial metabolite and an ICAM-1/LFA-1 mediated cell adhesion inhibitor.
Alicaforsen sodium (ISIS-2302 sodium) V56044 Alicaforsen sodium (ISIS-2302 sodium) 331257-52-4 Alicaforsen sodium is a 20-base antisense oligonucleotide that can inhibit the production of ICAM-1, an important adhesion molecule involved in the migration and transport of leukocytes to sites of inflammation.
Alicaforsen sodium scrambled negative control V128524 Alicaforsen sodium scrambled negative control The Alicaforsen sodium scrambled negative control is a negative control with the sequence of Alicaforsen sodium scrambled.
Alintegimod (7HP-349) V83227 Alintegimod (7HP-349) 1378535-08-0 Alintegimod (7HP-349) is variant activator of integrins αLβ2 and α4β1 that can enhance T cell activation and adhesion.
Alkyne-cRGD V106368 Alkyne-cRGD 2665674-77-9 Alkyne-cRGD is an integrin ligand.
Arg-Gly-Asp TFA V88820 Arg-Gly-Asp TFA 120103-89-1 Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence of integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.
Arg-Gly-Asp-Ser TFA (RGDS peptide TFA; Fibronectin tetrapeptide TFA) V78124 Arg-Gly-Asp-Ser TFA (RGDS peptide TFA; Fibronectin tetrapeptide TFA) Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that can inhibit integrin receptor function.
ASP5094 V129513 ASP5094 ASP5094 is a humanized monoclonal antibody targeting integrin α-9.
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