Integrins, a family of heterodimeric adhesion receptors for various extracellular matrices, have repeatedly been linked to being important initiators and promoters of ovarian cancer growth and progression. Aggressive ovarian tumors exhibit significantly elevated levels of several RGD-based integrin family members, including integrins 5-1 and v3 or v5. These adhesion receptors appear to encourage cell adhesion, survival, motility, and invasion during the development of an ovarian tumor or the spread of its metastatic disease. Notably, the activation of FAK and its downstream signaling, including the PI3K/Akt- and Ras/MAPK-dependent pathways, is crucial for the functions of these integrins.
Transmembrane proteins called integrins serve as important receptors for cell-extracellular matrix (ECM) and cell-cell adhesion.These molecules can be modified, and the v integrin family in particular, has shown to have significant effects on fibrosis in a variety of organs and disease states. According to numerous studies, the latent transforming growth factor (TGF)- is activated by the integrins v3, v5, v6, and v8 in pre-clinical fibrosis models, modulating the fibrotic process.
One of the 18 different types of subunits that are known to exist and one of the eight different types of subunits that are known to exist are typically non-covalently paired to form each integrin. There are currently 24 different heterodimers in total. The fact that the v subunit can form heterodimers with the 1, 3, 5, 6 or 8 subunits and that the 1 subunit can associate with a wide variety of subunits from 1 to 11 shows that not all theoretically possible and subunit pairs form. It's intriguing to note that a variety of v integrins appear to share a common function in TGF- activation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V77367 | (R/S)-Alicaforsen ((R/S)-ISIS-2302) | (R/S)-Alicaforsen is the racemate of Alicaforsen consisting of R and S configurations. | |
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V1598 | A-205804 | 251992-66-2 | A-205804 (A205804; A 205804) is a novel selective inhibitor of E-selectin and intercellular adhesion molecule-1 (ICAM-1) expression (IC50 = 20 nM and 25 nM) with potential anticancer activity. |
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V3083 | A286982 | 280749-17-9 | A-286982 isa potent inhibitor of the LFA-1/ICAM-1 interaction with IC50of 44 nM in an LFA-1/ICAM-1 binding assay. |
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V52457 | Abituzumab (EMD 525797; DI17E6) | 1105038-73-0 | Abituzumab (DI17E6) is a humanized anti-integrin αV monoclonal antibody (mAb) (IgG2 type). |
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V56051 | Abrilumab | 1342290-43-0 | Abrilumab is a fully human monoclonal antibody (mAb) directed against α4β7. |
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V56044 | Alicaforsen sodium (ISIS-2302 sodium) | 331257-52-4 | Alicaforsen sodium is a 20-base antisense oligonucleotide that can inhibit the production of ICAM-1, an important adhesion molecule involved in the migration and transport of leukocytes to sites of inflammation. |
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V83227 | Alintegimod (7HP-349) | 1378535-08-0 | Alintegimod (7HP-349) is variant activator of integrins αLβ2 and α4β1 that can enhance T cell activation and adhesion. |
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V78124 | Arg-Gly-Asp-Ser TFA (RGDS peptide TFA; Fibronectin tetrapeptide TFA) | Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that can inhibit integrin receptor function. | |
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V56048 | ATL 1102 (ISIS-107248) | 350263-41-1 | ATL 1102 is an antisense oligonucleotide targeting CD49d mRNA |
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V78147 | ATL 1102 sodium (ISIS-107248 sodium) | ATL 1102 sodium is an antisense oligonucleotide targeting CD49d mRNA | |
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V2794 | ATN-161 (Ac-PHSCN-NH2) | 262438-43-7 | ATN-161 is a novel and potent small peptide inhibitor of the integrin α5β1, it inhibits the angiogenesis and growth of liver metastases in a murine model. |
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V0434 | ATN-161 TFA | 904763-27-5 | ATN-161 TFA, the trifluoroacetic acid salt ofATN161, is a novel and potent small peptide inhibitor of the integrin α5β1 with potential anticancer activity. |
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V52341 | Bersanlimab (BI-505) | 1987854-08-9 | Bersanlimab (BI-505) is a fully human monoclonal antibody (mAb) targeting intercellular adhesion molecule-1 (ICAM-1 or CD54). |
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V52889 | Bexotegrast (PLN-74809) | 2376257-44-0 | Bexotegrast is a potent inhibitor of ανβ6 integrin. |
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V78567 | BT100 sodium | BT100 (sodium) is a nucleic acid aptamer that can inhibit/disrupts the binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb to prevent arterial thrombosis. | |
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V77182 | BT200 | BT200 is a polyethylene glycol-conjugated nucleic acid aptamer BT100, which can inhibit the binding of von Willebrand Factor (VWF) and platelet glycoprotein GPIb to prevent arterial thrombosis. | |
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V77177 | c(phg-isoDGR-(NMe)k) TFA | c(phg-isoDGR-(NMe)k) TFA is a potent and specific α5β1 integrin ligand with IC50 of 2.9 nM. | |
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V2806 | Cilengitide (EMD 121974) | 188968-51-6 | Cilengitide (also known as EMD 121974, NSC 707544) is a highly potent integrin inhibitor for the αvβ3 receptor and the αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; it showed ~10-fold selectivity against gpIIbIIIa. |
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V1596 | Cilengitide TFA (EMD 121974) | 199807-35-7 | Cilengitide TFA (also known as EMD 121974;NSC-707544;EMD-85189;D-03497), the trifluoroacetic acid salt of cilengitide, is a highly potent and selective integrin inhibitor for the αvβ3 receptor and the αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; it showed~10-fold selectivity against gpIIbIIIa. |
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V56045 | cRGDfK-thioacetyl ester | 393781-65-2 | cRGDfK-thioacetyl ester is a biologically active peptide molecule. |
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