Integrins, a family of heterodimeric adhesion receptors for various extracellular matrices, have repeatedly been linked to being important initiators and promoters of ovarian cancer growth and progression. Aggressive ovarian tumors exhibit significantly elevated levels of several RGD-based integrin family members, including integrins 5-1 and v3 or v5. These adhesion receptors appear to encourage cell adhesion, survival, motility, and invasion during the development of an ovarian tumor or the spread of its metastatic disease. Notably, the activation of FAK and its downstream signaling, including the PI3K/Akt- and Ras/MAPK-dependent pathways, is crucial for the functions of these integrins.
Transmembrane proteins called integrins serve as important receptors for cell-extracellular matrix (ECM) and cell-cell adhesion.These molecules can be modified, and the v integrin family in particular, has shown to have significant effects on fibrosis in a variety of organs and disease states. According to numerous studies, the latent transforming growth factor (TGF)- is activated by the integrins v3, v5, v6, and v8 in pre-clinical fibrosis models, modulating the fibrotic process.
One of the 18 different types of subunits that are known to exist and one of the eight different types of subunits that are known to exist are typically non-covalently paired to form each integrin. There are currently 24 different heterodimers in total. The fact that the v subunit can form heterodimers with the 1, 3, 5, 6 or 8 subunits and that the 1 subunit can associate with a wide variety of subunits from 1 to 11 shows that not all theoretically possible and subunit pairs form. It's intriguing to note that a variety of v integrins appear to share a common function in TGF- activation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V77367 | (R/S)-Alicaforsen ((R/S)-ISIS-2302) | (R/S)-Alicaforsen is the racemate of Alicaforsen consisting of R and S configurations. | |
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V1598 | A-205804 | 251992-66-2 | A-205804 (A205804; A 205804) is a novel selective inhibitor of E-selectin and intercellular adhesion molecule-1 (ICAM-1) expression (IC50 = 20 nM and 25 nM) with potential anticancer activity. |
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V88814 | A20FMDV2 | 932699-03-1 | A20FMDV2 is a selective αvβ6 integrin inhibitor (IC50: 3 nM) that is 1,000-fold more active against αvβ6 than against other RGD-directed integrins (αvβ3, αvβ5, and α5β1). |
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V3083 | A286982 | 280749-17-9 | A-286982 isa potent inhibitor of the LFA-1/ICAM-1 interaction with IC50of 44 nM in an LFA-1/ICAM-1 binding assay. |
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V56044 | Alicaforsen sodium (ISIS-2302 sodium) | 331257-52-4 | Alicaforsen sodium is a 20-base antisense oligonucleotide that can inhibit the production of ICAM-1, an important adhesion molecule involved in the migration and transport of leukocytes to sites of inflammation. |
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V83227 | Alintegimod (7HP-349) | 1378535-08-0 | Alintegimod (7HP-349) is variant activator of integrins αLβ2 and α4β1 that can enhance T cell activation and adhesion. |
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V88820 | Arg-Gly-Asp TFA | 120103-89-1 | Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence of integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. |
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V78124 | Arg-Gly-Asp-Ser TFA (RGDS peptide TFA; Fibronectin tetrapeptide TFA) | Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that can inhibit integrin receptor function. | |
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V56048 | ATL 1102 (ISIS-107248) | 350263-41-1 | ATL 1102 is an antisense oligonucleotide targeting CD49d mRNA |
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V78147 | ATL 1102 sodium (ISIS-107248 sodium) | ATL 1102 sodium is an antisense oligonucleotide targeting CD49d mRNA | |
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V2794 | ATN-161 (Ac-PHSCN-NH2) | 262438-43-7 | ATN-161 is a novel and potent small peptide inhibitor of the integrin α5β1, it inhibits the angiogenesis and growth of liver metastases in a murine model. |
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V0434 | ATN-161 TFA | 904763-27-5 | ATN-161 TFA, the trifluoroacetic acid salt ofATN161, is a novel and potent small peptide inhibitor of the integrin α5β1 with potential anticancer activity. |
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V52889 | Bexotegrast (PLN-74809) | 2376257-44-0 | Bexotegrast is a potent inhibitor of ανβ6 integrin. |
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V94249 | Bexotegrast hydrochloride | 2775365-40-5 | Bexotelast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual-selective inhibitor that actively targets αVβ1 and αVβ6. |
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V78567 | BT100 sodium | BT100 (sodium) is a nucleic acid aptamer that can inhibit/disrupts the binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb to prevent arterial thrombosis. | |
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V77182 | BT200 | BT200 is a polyethylene glycol-conjugated nucleic acid aptamer BT100, which can inhibit the binding of von Willebrand Factor (VWF) and platelet glycoprotein GPIb to prevent arterial thrombosis. | |
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V88819 | BT200 sodium | BT200 sodium is a polyethylene glycol-coupled nucleic acid aptamer BT100 that can inhibit the binding of von Willebrand Factor (VWF) to platelet glycoprotein GPIb and prevent arterial thrombosis. | |
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V93340 | c(avb6)-DOTA TFA | c(avb6)-DOTA TFA is a complex formed by modifying the αvβ6 integrin selective peptide ring with DPTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has considerable affinity for αvβ6 integrin (IC50=0.8 nM) and can be used for tumor diagnosis. | |
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V77177 | c(phg-isoDGR-(NMe)k) TFA | c(phg-isoDGR-(NMe)k) TFA is a potent and specific α5β1 integrin ligand with IC50 of 2.9 nM. | |
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V56045 | cRGDfK-thioacetyl ester | 393781-65-2 | cRGDfK-thioacetyl ester is a biologically active peptide molecule. |
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