HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V55241 | (E,E)-RGFP966 | 1396841-57-8 | (E,E)-RGFP966 is a selective CNS-permeable/penetrable HDAC3 inhibitor that may be utilized to study Huntington's disease. |
|
V75838 | (S)-TNG260 | 2935964-93-3 | (S)-TNG260 is an isomer of TNG260. |
|
V53007 | 5-Phenylpentan-2-one (phenylbutyric acid; phenylbutyric acid) | 2235-83-8 | 5-Phenylpentan-2-one is a potent inhibitor of histone deacetylase enzymes (HDACs). |
|
V52466 | 9-Hydroxyoctadecanoic acid (9-Hydroxystearic acid; 9-HSA) | 3384-24-5 | 9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that can suppress approximately 66.4% of HDAC1 enzymatic activity at 5 μM. |
|
V55240 | BChE/HDAC6-IN-1 | 2925457-27-6 | BChE/HDAC6-IN-1 is a potent and specific dual BChE/HDAC6 inhibitor (antagonist) with IC50s of 4 nM and 8.9 nM, respectively. |
|
V52358 | BChE/HDAC6-IN-2 | 2925457-33-4 | BChE/HDAC6-IN-2 (compound 29a) is a dual (bifunctional) inhibitor of BChE and HDAC6 with IC50 of 1.8 nM and 71.0 nM, respectively. |
|
V5095 | BML-210 (CAY10433) | 537034-17-6 | BML-210 (also known as BML210; CAY-10433) is novel and potent HDAC inhibitor (IC50 value: 5 μM) with anticancer activity. |
|
V4120 | Boc-Lys(Ac)-AMC | 233691-67-3 | Boc-Lys(Ac)-AMC is a cell-penetrating/penetrable fluorescent HDAC substrate (Ex/Em = 355 nm/460 nm). |
|
V55243 | Bocodepsin (OKI-179) | 1834513-65-3 | Bocodepsin (OKI-179) is an orally bioactive and selective HDAC inhibitor (antagonist) with anti-tumor activity. |
|
V55230 | Bocodepsin hydrochloride (OKI-179 hydrochloride) | 1834513-66-4 | Bocodepsin HCl (OKI-179) is an orally bioactive and selective HDAC inhibitor (antagonist) with anti-tumor activity. |
|
V52288 | CDK/HDAC-IN-3 | 2944087-54-9 | CDK/HDAC-IN-3 is an orally bioactive dual HDAC/CDK inhibitor. |
|
V52183 | Depudecin ((-)-Depudecin) | 139508-73-9 | Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. |
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V55234 | Dihydrochlamydocin | 52574-64-8 | Dihydrochlamydocin is a histone deacetylase (HDAC) inhibitor. |
|
V52174 | DKFZ-748 | 2490709-68-5 | DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66) and has anti-tumor activity. |
|
V52088 | FNDR-20123 | 2641930-61-0 | FNDR-20123 is an effective, safe, first-in-class anti-malarial HDAC inhibitor (antagonist) with IC50s of 31 nM and 3 nM against Plasmodium and human HDACs, respectively. |
|
V52089 | FNDR-20123 free base | 1267502-34-0 | FNDR-20123 free base is an effective, safe and first-in-class anti-malarial HDAC inhibitor (antagonist) with IC50 of 31 nM and 3 nM against Plasmodium and human HDAC respectively. |
|
V55227 | HDAC ligand-1 | 34840-28-3 | HDAC ligand-1 is an HDAC ligand that may be utilized to prepare PROTAC HDAC degraders. |
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V55239 | HDAC-IN-26 | 2410542-97-9 | HDAC-IN-26 is a selective class I HDAC inhibitor (antagonist) with EC50 of 4.7 nM. |
|
V22896 | HDAC-IN-27 | 2763368-89-2 | HDAC-IN-27 (Compound 11h) is a potent, orally bioactive, selective HDAC class I inhibitor (antagonist) with IC50s ranging from 0.43 to 3.01 nM for HDAC1-3. |
|
V55236 | HDAC-IN-28 | 1621154-88-8 | HDAC-IN-28 is a new type of HDAC inhibitor that has a strong inhibitory activity against tumor growth and metastasis. |
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