An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V33252 | 2-HBA | 131359-24-5 | 2-HBA, ananalog of curcumin,is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10. |
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V76052 | Ac-AAVALLPAVLLALLAP-LEVD-CHO | 886462-82-4 | Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-penetrating/penetrable caspase-4 inhibitor (antagonist) with anti-tumor activity. |
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V76050 | Ac-AAVALLPAVLLALLAP-YVAD-CHO | 201608-12-0 | Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-penetrating/penetrable caspase-1 inhibitor (antagonist) with anti-tumor activity. |
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V2777 | Ac-DEVD-CHO | 169332-60-9 | Ac-DEVD-CHO is a potent and specific aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. |
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V77300 | Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III TFA) | Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. | |
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V75995 | Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) | 775289-20-8 | Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50= 9.89, 245 nM, respectively; Kiapp: 0.68, 55.7 nM, respectively). |
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V75996 | Ac-VAD-pNA | 154564-07-5 | Ac-VAD-pNA is a caspase-1 substrate. |
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V75998 | Ac-VDVAD-pNA | 189684-53-5 | Ac-VDVAD-pNA is a caspase-2 substrate. |
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V75997 | Ac-VETD-AMC | 1135686-24-6 | Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. |
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V77291 | Ac-WEHD-AFC TFA | Ac-WEHD-AFC TFA is a fluorescent caspase-1 substrate. | |
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V69263 | ALK-IN-26 | 2447607-85-2 | ALK-IN-26 (compound 4a) is an ALK inhibitor (antagonist) with IC50 of 7.0 μM for ALK tyrosine kinase. |
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V80024 | Antiproliferative agent-42 | antiproliferation agent-42 (compound 7m) is a dihydrodipyrrole compound. | |
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V0024 | Belnacasan (VX765) | 273404-37-8 | Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. |
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V29824 | BOC-D-FMK | 634911-80-1 | Boc-D-FMK is a cell-permeable, irreversible (covalent) and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
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V78588 | C105SR | C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl prolyl trans-isomerase (PPIase). | |
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V79078 | Caspase-3 activator 2 | Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that causes apoptosis and may be utilized in cancer research. | |
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V79147 | Caspase-3 activator 3 | 2999724-52-4 | Caspase-3 activator 3 (compound 2h) can cause apoptosis in HL-60 and K562 cells by activating caspase 3. |
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V67696 | Estrogen receptor modulator 10 | 2991504-90-4 | Estrogen receptor modulator 10 (compound G-5b) is an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). |
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V76051 | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone | 1926163-65-6 | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable (penetrable), non-toxic inhibitor that interacts with activated caspase in apoptotic cells -3 Irreversible binding. |
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V80350 | IETD-CHO TFA | IETD-CHO TFA (Caspase-8-IN-1) is a potent caspase-8 inhibitor. |