The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84485 | (+)-Catechin pentaacetate | 16198-01-9 | |
|
V73504 | (-)-Bornyl ferulate | 55511-07-4 | (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor (antagonist) with IC50 of 10.4 μM and 12.0 μM respectively. |
|
V74812 | (rac)-Etodolac-d3 | 1276197-46-6 | (rac)-Etodolac-d3 is the deuterated racemate of Etodolac. |
|
V74816 | (Rac)-γ-Tocopherol (DMPBQ) | 73980-80-0 | (Rac)-γ-Tocopherol (DMPBQ) is a vitamin E isomer that is converted to γ-Tcopherol by tocopherol cyclase. |
|
V74830 | (±)-Naproxen-13C,d3 | 1261392-52-2 | (±)-Naproxen-13C,d3 is the deuterated form of 13C (carbon 13)-labeled (±)-Naproxen. |
|
v107926 | 1-(2,6-Dichlorophenyl)-2-indolinone | 15362-40-0 | |
|
V74835 | 1-Hydroxy-ibuprofen | 53949-53-4 | 1-Hydroxy Ibuprofen is the bioactive metabolite of Ibuprofen. |
|
V60106 | 2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol | 7295-85-4 | (±)-Catechin (rel-Cianidanol) is the racemate of catechin. |
|
V97057 | 2-(tert-Butyl)-4-methoxyphenol (Standard) | 121-00-6 | 2-(tert-Butyl)-4-methoxyphenol (Standard) is the analytical standard for 2-(tert-Butyl)-4-methoxyphenol. |
|
V109832 | 2-Chloro-N-(2,6-dimethylphenyl)acetamide | 1131-01-7 | Based on its molecular topology, 2-chloro-N-(2,6-dimethylphenyl)acetamide is predicted to be a cyclooxygenase (COX) inhibitor. |
|
V65886 | 2-Methoxy-3-octadecoxypropan-1-ol | 84337-43-9 | 1-O-Octadecyl-2-O-methyl-rac-glycerol is a biochemical compound that may be utilized as a biomaterial or organic/chemical reagent for biomedical research. |
|
V74869 | 3,9-Dihydroeucomin | 887375-68-0 | 3,9-DiHydreucomin (compound 12) is a natural isoflavone compound with low COX-2 inhibitory activity. |
|
V112684 | 3-Methyluracil | 608-34-4 | 3-Methyluracil (compound 5) is a pyrimidine heterocyclic compound that can be isolated from Cordyceps bassiana. |
|
V62727 | 4'-Aarboxylic acid imrecoxib | 896729-08-1 | 4'-Aarboxylic acid imrecoxib is a metabolite of Imrecoxib, a selective COX-II inhibitor. |
|
V74857 | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone | 151752-08-8 | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone inhibits COX-1 and COX-2 activity. |
|
V117475 | 4-Methoxycinnamic acid ethyl ester | 1929-30-2 | 4-Methoxycinnamate (ethyl p-methoxycinnamate) is an orally effective natural compound. |
|
V110575 | 4-Methylamino antipyrine-d3-1 | 1246820-06-3 | 4-Methylaminoantipyrine-d3-1 is a deuterated derivative of 4-methylaminoantipyrine-1. |
|
V110784 | 4F-PMPH | 4F-PMPH is a COX-II inhibitor with anti-inflammatory activity. | |
|
V102837 | 5'-Hydroxy meloxicam | 130262-92-9 | 5'-Hydroxymeloxicam is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) meloxicam. |
|
V116945 | Allyl thiosulfate | 6363-01-5 | Allyl thiosulfate (sodium 2-propenyl thiosulfate) is found in Allium species such as garlic and onion. |
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