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COX

COX

The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.

COX related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Catechin pentaacetate V84485 (+)-Catechin pentaacetate 16198-01-9
(+/-)-Catechin Gallate-13C3 (Catechin Gallate 13C3) V77404 (+/-)-Catechin Gallate-13C3 (Catechin Gallate 13C3) (+/-)-Catechin Gallate-13C3 is a 13C (carbon 13)-labeled (-)-Catechin gallate.
(-)-Bornyl ferulate V73504 (-)-Bornyl ferulate 55511-07-4 (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor (antagonist) with IC50 of 10.4 μM and 12.0 μM respectively.
(-)-Epicatechin-13C3 V121140 (-)-Epicatechin-13C3 (-)-Epicatechin-13C3 is a 13C-labeled (-)-epicatechin.
(rac)-Etodolac-d3 V74812 (rac)-Etodolac-d3 1276197-46-6 (rac)-Etodolac-d3 is the deuterated racemate of Etodolac.
(Rac)-γ-Tocopherol (DMPBQ) V74816 (Rac)-γ-Tocopherol (DMPBQ) 73980-80-0 (Rac)-γ-Tocopherol (DMPBQ) is a vitamin E isomer that is converted to γ-Tcopherol by tocopherol cyclase.
(S)-(+)-Ketoprofen-13C,d3 V122065 (S)-(+)-Ketoprofen-13C,d3 1330260-99-5 (S)-(+)-Ketoprofen-13C,d3 is S-(+)-ketoprofen labeled with deuterium and 13C.
(S)-氟比洛芬 V10613 Esflurbiprofen 51543-39-6 Esflurbiprofen (BTS-24332; TT 063; BTS24332;TT063; SFPP;BTS 24332; TT-063; Trade name: Loqoa), the S-enantiomrer or S-isomer of Flurbiprofen, is a potent cyclooxygenase (COX) inhibitor and anonsteroidal anti-inflammatory drugs (NSAIDs) with antipyretic and analgesic activity.
(±)-Ketoprofen glucuronide V121237 (±)-Ketoprofen glucuronide 76690-94-3 (±)-Ketoprofen glucuronide is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen.
(±)-Naproxen-13C,d3 V74830 (±)-Naproxen-13C,d3 1261392-52-2 (±)-Naproxen-13C,d3 is the deuterated form of 13C (carbon 13)-labeled (±)-Naproxen.
(±)16(17)-DiHDPA V121220 (±)16(17)-DiHDPA 1345275-27-5 (±)16(17)-DiHDPA is a metabolite of docosahexaenoic acid cyclooxygenase.
1-(2,6-Dichlorophenyl)-2-indolinone v107926 1-(2,6-Dichlorophenyl)-2-indolinone 15362-40-0
1-Hydroxy-ibuprofen V74835 1-Hydroxy-ibuprofen 53949-53-4 1-Hydroxy Ibuprofen is the bioactive metabolite of Ibuprofen.
2,5-Dimethoxy-3-glucopyranosylcinnamic alcohol V124168 2,5-Dimethoxy-3-glucopyranosylcinnamic alcohol 251660-72-7 2,5-Dimethoxy-3-pyranoglucosylcinnamyl alcohol is found in senna (P. crocatum) and swamp violet (Dirca palustris).
2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol V60106 2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol 7295-85-4 (±)-Catechin (rel-Cianidanol) is the racemate of catechin.
2-(tert-Butyl)-4-methoxyphenol (Standard) V97057 2-(tert-Butyl)-4-methoxyphenol (Standard) 121-00-6 2-(tert-Butyl)-4-methoxyphenol (Standard) is the analytical standard for 2-(tert-Butyl)-4-methoxyphenol.
2-(乙酰氧基)-苯甲酸3-[(硝基氧基)甲基]苯基酯 V12164 Nitroaspirin 175033-36-0 Nitroaspirin (NOASA;NCX4016; mNOASA) is a novel and potent nitric oxide (NO) donor with anticancer, antithrombotic and anti-platelet activities.
2-Chloro-N-(2,6-dimethylphenyl)acetamide V109832 2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7 Based on its molecular topology, 2-chloro-N-(2,6-dimethylphenyl)acetamide is predicted to be a cyclooxygenase (COX) inhibitor.
2-Methoxy-3-octadecoxypropan-1-ol V65886 2-Methoxy-3-octadecoxypropan-1-ol 84337-43-9 1-O-Octadecyl-2-O-methyl-rac-glycerol is a biochemical compound that may be utilized as a biomaterial or organic/chemical reagent for biomedical research.
2-O-Sinapoyl makisterone A V77593 2-O-Sinapoyl makisterone A 2-O-Sinapoyl makisterone A (compound 2) is a sinapic acid-ecdysterone hybrid and is a selective inhibitor of COX-2.
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