The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84485 | (+)-Catechin pentaacetate | 16198-01-9 | |
|
V73504 | (-)-Bornyl ferulate | 55511-07-4 | (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor (antagonist) with IC50 of 10.4 μM and 12.0 μM respectively. |
|
V74812 | (rac)-Etodolac-d3 | 1276197-46-6 | (rac)-Etodolac-d3 is the deuterated racemate of Etodolac. |
|
V74816 | (Rac)-γ-Tocopherol (DMPBQ) | 73980-80-0 | (Rac)-γ-Tocopherol (DMPBQ) is a vitamin E isomer that is converted to γ-Tcopherol by tocopherol cyclase. |
|
V74830 | (±)-Naproxen-13C,d3 | 1261392-52-2 | (±)-Naproxen-13C,d3 is the deuterated form of 13C (carbon 13)-labeled (±)-Naproxen. |
|
V74835 | 1-Hydroxy-ibuprofen | 53949-53-4 | 1-Hydroxy Ibuprofen is the bioactive metabolite of Ibuprofen. |
|
V60106 | 2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol | 7295-85-4 | (±)-Catechin (rel-Cianidanol) is the racemate of catechin. |
|
V65886 | 2-Methoxy-3-octadecoxypropan-1-ol | 84337-43-9 | 1-O-Octadecyl-2-O-methyl-rac-glycerol is a biochemical compound that may be utilized as a biomaterial or organic/chemical reagent for biomedical research. |
|
V74869 | 3,9-Dihydroeucomin | 887375-68-0 | 3,9-DiHydreucomin (compound 12) is a natural isoflavone compound with low COX-2 inhibitory activity. |
|
V62727 | 4'-Aarboxylic acid imrecoxib | 896729-08-1 | 4'-Aarboxylic acid imrecoxib is a metabolite of Imrecoxib, a selective COX-II inhibitor. |
|
V74857 | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone | 151752-08-8 | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone inhibits COX-1 and COX-2 activity. |
|
V74833 | Anti-inflammatory agent 10 | 2910876-55-8 | Anti-inflammatory agent 10 (Compound 30) is a benzimidazole thiazole analogue based on tilomisole. |
|
V74864 | Anti-inflammatory agent 56 | 2413127-32-7 | Anti-inflammatory agent 56 (Compound 9) is a selective COX-2 inhibitor (IC50= 0.54 μM). |
|
V74839 | Anti-inflammatory agent 9 | 2910876-54-7 | Anti-inflammatory agent 9 (compound 28) is a benzimidazole thiazole analogue based on tilomisole. |
|
V74844 | Antioxidant agent-15 | 596-38-3 | Antioxidant agent-15 (Compound 4) has strong antioxidant inhibitory activity, with IC50 of 15.44 nM. |
|
V74861 | Antitumor agent-77 | 2870703-21-0 | Antitumor agent-77 has anti-tumor activity and can suppress the growth and migration of cancer cells. |
|
V74862 | Antitumor agent-78 | 2870703-23-2 | Antitumor agent-78 has anti-tumor activity and can suppress the growth and migration of cancer cells. |
|
V84062 | Ataquimast free base | 586348-21-2 | |
|
V73501 | Atractylochromene | 203443-33-8 | Atractylochromene is a potent dual (bifunctional) inhibitor of 5-LOX and COX-1 with IC50 of 0.6 and 3.3 μM respectively. |
|
V74858 | Axinelline A | 1593741-99-1 | Axinelline A is a potent COX inhibitor (antagonist) with IC50s of 2.22 μM and 8.89 μM for COX-2 and COX-1 respectively. |
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