Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V72067 | (+)-Medioresinol Di-O-β-D-glucopyranoside | 88142-63-6 | (+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity against 3',5'-cyclic monophosphate (cyclic AMP) phosphodiesterase. |
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V3497 | (R)-(-)-Rolipram | 85416-75-7 | R)-(-)-Rolipram is the R-enantiomer of Rolipram with potent anti-inflammatory and anti-depressant activity in the central nervous system, and it is more potent than its S enantiomer. |
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V72071 | (R)-Avanafil ((R)-TA1790) | 1638497-26-3 | (R)-Avanafil ((R)-TA1790) is a selective PDE5 inhibitor (IC50= 5.2 nM). |
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V72042 | (R)-Irsenontrine ((R)-E2027) | 1429509-81-8 | (R)-Irsenontrine ((R)-E2027) is the R-isomer of Irsenontrine and is a potent inhibitor of phosphodiesterase 9 (PDE9) with IC50 of 0.041 μM. |
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V93144 | (R)-Tanimilast | (R)-Tanimilast is an isomer of Tanimilast. | |
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V101579 | (S)-Gebr32a | (S)-Gebr32a is a potent PDE4 inhibitor with IC50 values of 19.5 and 2.1 µM for PDE4 cat and PDE4D3, respectively. | |
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V77359 | (S)-PF-04449613 | (S)-PF-04449613 is the left-handed isomer of PF-04449613. | |
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V72077 | 1,3,5-Trihydroxy-4-prenylxanthone | 53377-61-0 | 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ (Na+/H+ Exchanger (NHE)) exchange system inhibitor (antagonist) with a minimum inhibitory concentration of 10 μg/mL. |
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V94604 | 1-Phenyl-3,4-dihydroisoquinoline | 52250-50-7 | 1-Phenyl-3,4-dihydroisoquinoline (Compound 13) inhibits cyclic nucleotide phosphodiesterase (PDE). |
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V92440 | 2'-O-MB-cGMP sodium | 58329-72-9 | 2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium is a cyclic GMP-specific phosphodiesterase inhibitor with an I50 of 35 µM. |
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V72020 | 3-O-Methylquercetin | 1486-70-0 | 3-O-Methylquercetin (3-MQ) is a major component from the plant Rhamnus nakaharai and inhibits total cAMP and cGMP-phosphodiesterase (PDE). |
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V4097 | 3-Isobutyl-1-methylxanthine | 28822-58-4 | IBMX is anonspecific, broad-spectrum, competitive inhibitor of phosphodiesterase (PDE) inhibitor, withIC50s of 6.5, 26.3 and 31.7 μM forPDE3,PDE4andPDE5, respectively. |
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V72054 | 4'-Methoxyisoagarotetrol | 104901-10-2 | 4'-Methoxyisoagarotetrol is a pigment analogue with moderate PDE?3A inhibitory activity (IC50=54 μM). |
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V100227 | 4-Pentadecylbenzylphosphonic acid | 1306684-90-1 | 4-Pentadecanylbenzylphosphonic acid is an inhibitor of autotaxin (ATX). |
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V101090 | 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione | 333409-31-7 | 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor of snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM, respectively. |
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V92447 | 5,6-DCl-cBIMP | 129693-10-3 | 5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolysis activity of PDE2. |
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V90295 | 5,6-DM-cBIMP | 142754-31-2 | 5,6-DM-cBIMP, a cyclic nucleotide analog, is a PDE2 agonist and can significantly increase the cAMP and cGMP hydrolysis activities of PDE2. |
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V101309 | 6-Cl-cPuMP sodium | 94200-58-5 | 6-Cl-cPuMP(sodium) is a cAMP analog with active chlorine function. |
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V40090 | ent-Tadalafil | 629652-72-8 | ent-Tadalafil(ent-IC-351) is a cis-enantiomer and animpurity of Tadalafil, which is an inhibitor of PDE5/phosphodiesterase 5 approved as an oral drug for treating erectile dysfunction (ED). |
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V69108 | 8-CPT-Cyclic AMP sodium (8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium) | 93882-12-3 | 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase. |