Phosphodiesterase(PDE)

Phosphodiesterase(PDE)

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.

Phosphodiesterase(PDE) related products

Structure Cat No. Product Name CAS No. Product Description
V72067 (+)-Medioresinol Di-O-β-D-glucopyranoside 88142-63-6
V3497 (R)-(-)-Rolipram 85416-75-7 R)-(-)-Rolipram is the R-enantiomer of Rolipram with potent anti-inflammatory and anti-depressant activity in the central nervous system, and it is more potent than its S enantiomer.
V72071 (R)-Avanafil ((R)-TA1790) 1638497-26-3
V72042 (R)-Irsenontrine ((R)-E2027) 1429509-81-8
V77359 (S)-PF-04449613
V72077 1,3,5-Trihydroxy-4-prenylxanthone 53377-61-0
V72020 3-O-Methylquercetin 1486-70-0
V72054 4'-Methoxyisoagarotetrol 104901-10-2
V69108 8-CPT-Cyclic AMP sodium (8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium) 93882-12-3
V72088 Ambuphylline (bufylline; Bufylline) 5634-34-4
V3461 AMG-579 1227067-61-9 AMG 579 is a novel, potent, selective, and highly efficacious phosphodiesterase 10A (PDE10A) inhibitorwith anIC50of 0.1 nM.
V72081 Anagrelide hydrochloride monohydrate 823178-43-4
V72039 Andolast (CR 2039; Dizolast) 143330-46-5
V72068 ATX inhibitor 12 2771312-16-2
V72072 ATX inhibitor 18 2402772-30-7
V72089 ATX inhibitor 22 2969213-59-8
V72043 ATX inhibitor 7 1646784-47-5
V72056 ATX inhibitor 8 2156656-37-8
V72046 Autotaxin-IN-6 2800898-98-8
V72028 Ayanin 572-32-7
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