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Phosphodiesterase(PDE)

Phosphodiesterase(PDE)

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.

Phosphodiesterase(PDE) related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Medioresinol Di-O-β-D-glucopyranoside V72067 (+)-Medioresinol Di-O-β-D-glucopyranoside 88142-63-6 (+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity against 3',5'-cyclic monophosphate (cyclic AMP) phosphodiesterase.
(R)-(-)-咯利普兰 V3497 (R)-(-)-Rolipram 85416-75-7 R)-(-)-Rolipram is the R-enantiomer of Rolipram with potent anti-inflammatory and anti-depressant activity in the central nervous system, and it is more potent than its S enantiomer.
(R)-Avanafil ((R)-TA1790) V72071 (R)-Avanafil ((R)-TA1790) 1638497-26-3 (R)-Avanafil ((R)-TA1790) is a selective PDE5 inhibitor (IC50= 5.2 nM).
(R)-Irsenontrine ((R)-E2027) V72042 (R)-Irsenontrine ((R)-E2027) 1429509-81-8 (R)-Irsenontrine ((R)-E2027) is the R-isomer of Irsenontrine and is a potent inhibitor of phosphodiesterase 9 (PDE9) with IC50 of 0.041 μM.
(R)-Tanimilast V93144 (R)-Tanimilast (R)-Tanimilast is an isomer of Tanimilast.
(S)-Gebr32a V101579 (S)-Gebr32a (S)-Gebr32a is a potent PDE4 inhibitor with IC50 values of 19.5 and 2.1 µM for PDE4 cat and PDE4D3, respectively.
(S)-PF-04449613 V77359 (S)-PF-04449613 (S)-PF-04449613 is the left-handed isomer of PF-04449613.
1,3,5-Trihydroxy-4-prenylxanthone V72077 1,3,5-Trihydroxy-4-prenylxanthone 53377-61-0 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ (Na+/H+ Exchanger (NHE)) exchange system inhibitor (antagonist) with a minimum inhibitory concentration of 10 μg/mL.
1-Phenyl-3,4-dihydroisoquinoline V94604 1-Phenyl-3,4-dihydroisoquinoline 52250-50-7 1-Phenyl-3,4-dihydroisoquinoline (Compound 13) inhibits cyclic nucleotide phosphodiesterase (PDE).
2'-O-MB-cGMP sodium V92440 2'-O-MB-cGMP sodium 58329-72-9 2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium is a cyclic GMP-specific phosphodiesterase inhibitor with an I50 of 35 µM.
3-O-Methylquercetin V72020 3-O-Methylquercetin 1486-70-0 3-O-Methylquercetin (3-MQ) is a major component from the plant Rhamnus nakaharai and inhibits total cAMP and cGMP-phosphodiesterase (PDE).
3-异丁基-1-甲基黄嘌呤 V4097 3-Isobutyl-1-methylxanthine 28822-58-4 IBMX is anonspecific, broad-spectrum, competitive inhibitor of phosphodiesterase (PDE) inhibitor, withIC50s of 6.5, 26.3 and 31.7 μM forPDE3,PDE4andPDE5, respectively.
4'-Methoxyisoagarotetrol V72054 4'-Methoxyisoagarotetrol 104901-10-2 4'-Methoxyisoagarotetrol is a pigment analogue with moderate PDE?3A inhibitory activity (IC50=54 μM).
4-Pentadecylbenzylphosphonic acid V100227 4-Pentadecylbenzylphosphonic acid 1306684-90-1 4-Pentadecanylbenzylphosphonic acid is an inhibitor of autotaxin (ATX).
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione V101090 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione 333409-31-7 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor of snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM, respectively.
5,6-DCl-cBIMP V92447 5,6-DCl-cBIMP 129693-10-3 5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolysis activity of PDE2.
5,6-DM-cBIMP V90295 5,6-DM-cBIMP 142754-31-2 5,6-DM-cBIMP, a cyclic nucleotide analog, is a PDE2 agonist and can significantly increase the cAMP and cGMP hydrolysis activities of PDE2.
6-Cl-cPuMP sodium V101309 6-Cl-cPuMP sodium 94200-58-5 6-Cl-cPuMP(sodium) is a cAMP analog with active chlorine function.
6S,12S-他达拉非(EP杂质B) V40090 ent-Tadalafil 629652-72-8 ent-Tadalafil(ent-IC-351) is a cis-enantiomer and animpurity of Tadalafil, which is an inhibitor of PDE5/phosphodiesterase 5 approved as an oral drug for treating erectile dysfunction (ED).
8-CPT-Cyclic AMP sodium (8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium) V69108 8-CPT-Cyclic AMP sodium (8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium) 93882-12-3 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase.
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