Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72067 | (+)-Medioresinol Di-O-β-D-glucopyranoside | 88142-63-6 | (+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity against 3',5'-cyclic monophosphate (cyclic AMP) phosphodiesterase. |
|
V3497 | (R)-(-)-Rolipram | 85416-75-7 | R)-(-)-Rolipram is the R-enantiomer of Rolipram with potent anti-inflammatory and anti-depressant activity in the central nervous system, and it is more potent than its S enantiomer. |
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V72071 | (R)-Avanafil ((R)-TA1790) | 1638497-26-3 | (R)-Avanafil ((R)-TA1790) is a selective PDE5 inhibitor (IC50= 5.2 nM). |
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V72042 | (R)-Irsenontrine ((R)-E2027) | 1429509-81-8 | (R)-Irsenontrine ((R)-E2027) is the R-isomer of Irsenontrine and is a potent inhibitor of phosphodiesterase 9 (PDE9) with IC50 of 0.041 μM. |
|
V77359 | (S)-PF-04449613 | (S)-PF-04449613 is the left-handed isomer of PF-04449613. | |
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V72077 | 1,3,5-Trihydroxy-4-prenylxanthone | 53377-61-0 | 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ (Na+/H+ Exchanger (NHE)) exchange system inhibitor (antagonist) with a minimum inhibitory concentration of 10 μg/mL. |
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V72020 | 3-O-Methylquercetin | 1486-70-0 | 3-O-Methylquercetin (3-MQ) is a major component from the plant Rhamnus nakaharai and inhibits total cAMP and cGMP-phosphodiesterase (PDE). |
|
V4097 | 3-Isobutyl-1-methylxanthine | 28822-58-4 | IBMX is anonspecific, broad-spectrum, competitive inhibitor of phosphodiesterase (PDE) inhibitor, withIC50s of 6.5, 26.3 and 31.7 μM forPDE3,PDE4andPDE5, respectively. |
|
V72054 | 4'-Methoxyisoagarotetrol | 104901-10-2 | 4'-Methoxyisoagarotetrol is a pigment analogue with moderate PDE?3A inhibitory activity (IC50=54 μM). |
|
V69108 | 8-CPT-Cyclic AMP sodium (8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium) | 93882-12-3 | 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase. |
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V72088 | Ambuphylline (bufylline; Bufylline) | 5634-34-4 | Ambuphylline (Bufylline) is a bronchodilator. |
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V3461 | AMG-579 | 1227067-61-9 | AMG 579 is a novel, potent, selective, and highly efficacious phosphodiesterase 10A (PDE10A) inhibitorwith anIC50of 0.1 nM. |
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V72081 | Anagrelide hydrochloride monohydrate | 823178-43-4 | Anagrelide HCl monohydrate is an imidazoquinazoline preparation. |
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V72039 | Andolast (CR 2039; Dizolast) | 143330-46-5 | Andolast (CR 2039) is an anti-allergic agent. |
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V72068 | ATX inhibitor 12 | 2771312-16-2 | ATX inhibitor 12 (compound 20) is an orally bioavailable ATX inhibitor (antagonist) with IC50 of 1.72 nM. |
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V72072 | ATX inhibitor 18 | 2402772-30-7 | ATX inhibitor 18 is a potent ATX inhibitor (antagonist) with IC50 of 24.2 nM. |
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V72089 | ATX inhibitor 22 | 2969213-59-8 | ATX inhibitor 22 is a new ATX (autaxin) inhibitor (antagonist) with a corresponding IC50 of 218.9 μM, but lacks LPAR1 inhibitory activity. |
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V72043 | ATX inhibitor 7 | 1646784-47-5 | ATX inhibitor 7 is an Autotaxin inhibitor (antagonist) with good oral exposure. |
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V72056 | ATX inhibitor 8 | 2156656-37-8 | ATX inhibitor 8 is an inhibitor (blocker/antagonist) of the autotaxin (ATX) factor. |
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V72046 | Autotaxin-IN-6 | 2800898-98-8 | Autotaxin-IN-6 (compound 23) is an autotaxin (ATX) inhibitor (antagonist) with IC50 of 30 nM. |
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