FTO

FTO

Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. Previous research showed that FTO is essential for adipogenesis and energy homeostasis. In contrast to mice with overexpressed FTO, which resulted in obesity, FTO-deficient mice show postnatal growth retardation, reduced food intake, and a significant reduction of adipose tissue.

Additionally, the crucial roles that FTO plays in neurogenesis, learning, and memory may be connected to its function as an RNA demethylase of N6-methyladenosine (m6A). Additionally discovered to be highly abundant in the brain, FTO protein is linked to decreased brain volume in children and the elderly. In addition to affecting the dopamine receptor 2- and 3-dependent control of neuronal activity and locomotor behavioral responses, FTO gene deficiency increases the retention of fear memory.

FTO related products

Structure Cat No. Product Name CAS No. Product Description
V41317 FB23 2243736-35-6 FB23 is a novel, potent and selective inhibitor (IC50 of 60 nM) of FTO demethylase, an mRNA N6-methyladenosine (m6A) demethylase that was reported to promote leukemogenesis.
V2426 FTO-IN-1 2243944-92-3 FTO-IN-1 is a FTO inhibitor with the potential to treat obesity, breast cancers, pancreatic cancer, and Alzheimer's diseases.
V74013 FTO-IN-1 TFA 2797619-81-7
V74012 FTO-IN-2 2585198-85-0
V74014 FTO-IN-3 2585198-87-2
V74015 FTO-IN-4 2763577-74-6
V74016 FTO-IN-5 2763577-75-7
V74010 FTO-IN-6 2968347-63-7
V74011 N6,2′-O-Dimethyladenosine 57817-83-1
V78580 ZLD115
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