Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. Previous research showed that FTO is essential for adipogenesis and energy homeostasis. In contrast to mice with overexpressed FTO, which resulted in obesity, FTO-deficient mice show postnatal growth retardation, reduced food intake, and a significant reduction of adipose tissue.
Additionally, the crucial roles that FTO plays in neurogenesis, learning, and memory may be connected to its function as an RNA demethylase of N6-methyladenosine (m6A). Additionally discovered to be highly abundant in the brain, FTO protein is linked to decreased brain volume in children and the elderly. In addition to affecting the dopamine receptor 2- and 3-dependent control of neuronal activity and locomotor behavioral responses, FTO gene deficiency increases the retention of fear memory.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V41317 | FB23 | 2243736-35-6 | FB23 is a novel, potent and selective inhibitor (IC50 of 60 nM) of FTO demethylase, an mRNA N6-methyladenosine (m6A) demethylase that was reported to promote leukemogenesis. |
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V2426 | FTO-IN-1 | 2243944-92-3 | FTO-IN-1 is an inhibitor (blocker/antagonist) of fat and obesity-related enzymes (FTO) with IC50 of <1 μM. |
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V74013 | FTO-IN-1 TFA | 2797619-81-7 | FTO-IN-1 TFA is an inhibitor (blocker/antagonist) of fat and obesity-related enzymes (FTO) with IC50 of <1 μM. |
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V74012 | FTO-IN-2 | 2585198-85-0 | FTO-IN-2 is an FTO inhibitor that can suppress glioblastoma stem cell self-renewal. |
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V74014 | FTO-IN-3 | 2585198-87-2 | FTO-IN-3 is an FTO inhibitor that can suppress self-renewal of glioblastoma stem cells. |
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V74015 | FTO-IN-4 | 2763577-74-6 | FTO-IN-4 is a potent and specific inhibitor of fat mass and obesity-related proteins (FTO). |
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V74016 | FTO-IN-5 | 2763577-75-7 | FTO-IN-5 is a potent and specific inhibitor of fat mass and obesity-related proteins (FTO). |
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V74010 | FTO-IN-6 | 2968347-63-7 | FTO-IN-6 is a selective fat mass and obesity-associated protein (FTO) inhibitor. |
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V74011 | N6,2′-O-Dimethyladenosine | 57817-83-1 | N6,2′-O-Dimethyladenosine, a substrate of fat mass and obesity-related genes (FTO), is a reversible modification widely present on various RNA molecules. |
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V78580 | ZLD115 | ZLD115 (compound 44) is an FB23-derived inhibitor of fat mass and obesity-related proteins (FTO). |
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