HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate.Eukaryotes and prokaryotes both contain HMGCR. Two classes of HMG-CoA reductase have been identified through phylogenetic analysis: Class I enzymes found in some eukaryotes and archaea and Class II enzymes found in some eubacteria and other archaea.
The enzyme HMGCR is known to catalyze an early reaction specific to isoprenoid biosynthesis in both eukaryotes and archaebacteria. Drugs used to lower serum cholesterol levels frequently target the HMG-CoA reductase reaction because it is rate-limiting for the biosynthesis of cholesterol in humans.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V0928 | Atorvastatin Calcium | 134523-03-8 | Atorvastatin Calcium (CI-981; CI981; Atorvastatin hemicalcium; liptonorm),an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic medications, is a potent and selectiveinhibitor of HMG-CoA reductase with anti-hyperlipidemic effects. |
|
V0930 | Clinofibrate | 30299-08-2 | Clinofibrate (Lipoclin; S-8527; S 8527) is a potent anti-hyperlipidemic agent which acts as an HMG-CoA (hydroxymethylglutaryl coenzyme A) reductase inhibitorwith potential anti-hyperlipidemic effects. |
|
V0927 | Fluvastatin Sodium | 93957-55-2 | Fluvastatin (XU-62320;Fluindostatin; Lescol XL;XU-62-320; Canef; Lipaxan; Vastin), an approved drug belonging to the statin class of hypolipidemic medications, is a potent inhibitor of HMG-CoA reductase activity with potential anti-hyperlipidemic effects. |
|
V0926 | Lovastatin | 75330-75-5 | Lovastatin (Mevinolin; Mevacor;MK-803; Altoprev; Monacolin K; MK803), belonging to the statin class of hypolipidemic agent/lipid-lowering drugs,isa potent andcell-permeableinhibitor of HMG-CoA reductase with potential anti-hyperlipidemic effects. |
|
V0931 | Mevastatin | 73573-88-3 | Mevastatin (CS500;ML236B; Mevastatin; Compactin;ML-236B),an approved anti-hyperliperdemic drug of the statin class, is a potent and competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with anti-hyperlipidemic effects. |
|
V0929 | Pravastatin sodium | 81131-70-6 | Pravastatin sodium (Apotex;CS-514; Pravachol; Pravaselect; Apo-Pravastatin;Mevalotin; Elisor; Lipostat), an approved hypolipidemic drug of the statin class, is an HMG-CoA reductase inhibitor against sterol synthesis with potential anti-hyperlipidemic effects. |
|
V3294 | Rosuvastatin | 287714-41-4 | Rosuvastatin (S-4522; ZD-4522;S4522; ZD4522; trade name: Crestor) is a member of the statin class of antihyperlipidemic drugs which acts as a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
|
V0925 | Rosuvastatin Calcium | 147098-20-2 | Rosuvastatin Calcium (S-4522,Rosuvastatin hemicalcium; ZD-4522; ZD4522, trade name: Crestor), a member of the statin class of lipid-lowering drugs, is a potent and competitive inhibitor of HMG-CoA reductase with potential anti-hyperlipidemic activity. |
|
V3295 | Rosuvastatin D3 Sodium | 1279031-70-7 | Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin (also known as S-4522 and ZD 4522, trade name: Crestor) which is a member of the statin class of drugs and a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
|
V0924 | Simvastatin | 79902-63-9 | Simvastatin (MK0733, Zocor; Synvinolin; Sinvacor;MK-0733; SIM), a marketed anti-hyperlipidemic drug of the statin class, is a lactone prodrug that has to be activated through hydrolysis to the active β-hydroxy acid form, which then acts as a potent andcompetitive inhibitor of HMG-CoA (3-hydroxy-3-methyl glutaryl coenzyme A) reductase with Ki of 0.1-0.2 nM in cell-free assays. |
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