yingweiwo

ChE

ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Balanophonin V71637 (+)-Balanophonin 215319-47-4 (+)-Balanophonin is a natural phenolic compound extracted from Passiflora edulis and has antioxidant, anticholinesterase, anti~inflammatory, anticancer and anti-neurodegenerative activities.
(R)-Donepezil ((R)-Donepezil; (R)-E2020 free base) V71626 (R)-Donepezil ((R)-Donepezil; (R)-E2020 free base) 142698-19-9 (R)-Donepezil is the R-enantiomer of Donepezil .
(rac)-Rivastigmine-d6 (rivastigmine d6) V71649 (rac)-Rivastigmine-d6 (rivastigmine d6) 194930-04-6 (rac)-Rivastigmine-d6 is the deuterated racemate of Rivastigmine.
(Rac)-Sclerone V71697 (Rac)-Sclerone 19638-58-5 (Rac)-Sclerone is a naturally occurring compound that can be extracted from the green shell of pecans.
(S)-Donepezil ((S)-E2020 free base) V71614 (S)-Donepezil ((S)-E2020 free base) 142057-80-5 (S)-Donepezil is the R-enantiomer of Donepezil.
(±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) V71615 (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) 2504-11-2 (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist/activator with cholinergic properties.
2'-O-Succinyl-cAMP V71645 2'-O-Succinyl-cAMP 36940-87-1 2'-O-Succinyl-cAMP, a cAMP analog, can be covalently coupled to acetylcholinesterase.
3β-Hydroxy-lup-20(29)-en-16-one V71631 3β-Hydroxy-lup-20(29)-en-16-one 65043-60-9 3β-Hydroxy-lup-20(29)-en-16-one (compound 9) is a dual (bifunctional) inhibitor of AChE and BChE, with selectivity for BChE (IC50= 28.9 μM).
4-Methylbenzylidene camphor-d4 V71651 4-Methylbenzylidene camphor-d4 1219806-41-3 4-Methylbenzylidene camphor-d4 is the deuterated form of 4-Methylbenzylidene camphor.
7-Acetoxy-1-methylquinolinium iodide (AMQI) V71630 7-Acetoxy-1-methylquinolinium iodide (AMQI) 7270-83-9 7-Acetoxy-1-methylquinolinium iodide (AMQI) is a fluorescent substrate for cholinesterase (Ex = 320 nm, Em = 410 nm).
Acacetin-7-O-β-D-galactopyranoside V71679 Acacetin-7-O-β-D-galactopyranoside 80443-15-8 Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be extracted from the flower heads of Chrysanthemum morifolium.
Acephate (acephate; acephate) V71681 Acephate (acephate; acephate) 30560-19-1 Acephate is a broad-spectrum anticholinesterase insecticide.
Acetylcholinesterase (ACHE; EC 3.1.1.7) V71613 Acetylcholinesterase (ACHE; EC 3.1.1.7) 9000-81-1 Acetylcholinesterase (ACHE; EC 3.1.1.7), acetylcholinesterase, is a cholinergic enzyme that mainly exists in neuromuscular junctions and cholinergic type chemical synapses and is widely utilized in biochemical research.
AChE-IN-10 V71690 AChE-IN-10 2770832-90-9 AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM).
AChE-IN-28 V77754 AChE-IN-28 AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase (acetylcholinesterase) with IC50 of 0.2 nM.
AChE-IN-29 V77755 AChE-IN-29 AChE-IN-29, a 3-OH pyrrolidine analogue, is a cholinesterase ChE inhibitor.
AChE-IN-3 V71665 AChE-IN-3 2713548-95-7 AChE-IN-3 has moderate inhibitory activity against AChE and strong inhibitory activity against NO, with EC50 of 0.57 μM.
AChE-IN-31 V71658 AChE-IN-31 1325209-07-1 AChE-IN-31 (Compound 1) is a noncompetitive AChE inhibitor (antagonist) with potential for studying Alzheimer's disease (AD).
AChE-IN-34 V79965 AChE-IN-34 AChE-IN-34 (compound 5l) is a potent and specific AChE inhibitor (antagonist) with IC50 of 3.98 µM and no obvious inhibitory effect on BChE.
AChE-IN-35 V79888 AChE-IN-35 AChE-IN-35 (compound 5g) is an acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 5.88 μM.
Contact Us