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ChE

ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Balanophonin V71637 (+)-Balanophonin 215319-47-4 (+)-Balanophonin is a natural phenolic compound extracted from Passiflora edulis and has antioxidant, anticholinesterase, anti~inflammatory, anticancer and anti-neurodegenerative activities.
(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol V121580 (3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol 126594-75-0 (3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol is an acetylcholinesterase (AChE) inhibitor.
(E)-2-Nitrocinnamic acid V121733 (E)-2-Nitrocinnamic acid 1013-96-3 (E)-2-Nitrocinnamic acid is an acetylcholinesterase inhibitor.
(R)-Donepezil ((R)-Donepezil; (R)-E2020 free base) V71626 (R)-Donepezil ((R)-Donepezil; (R)-E2020 free base) 142698-19-9 (R)-Donepezil is the R-enantiomer of Donepezil .
(rac)-Rivastigmine-d6 (rivastigmine d6) V71649 (rac)-Rivastigmine-d6 (rivastigmine d6) 194930-04-6 (rac)-Rivastigmine-d6 is the deuterated racemate of Rivastigmine.
(Rac)-Sclerone V71697 (Rac)-Sclerone 19638-58-5 (Rac)-Sclerone is a naturally occurring compound that can be extracted from the green shell of pecans.
(Rac)-TZ3O V101850 (Rac)-TZ3O 2218754-19-7 (Rac)-TZ3O is the (Rac) isomer of TZ3O.
(S)-Donepezil ((S)-E2020 free base) V71614 (S)-Donepezil ((S)-E2020 free base) 142057-80-5 (S)-Donepezil is the R-enantiomer of Donepezil.
(S)-Ladostigil V97126 (S)-Ladostigil 209394-29-6 (S)-Ladostigil (TV-3279) is the S-enantiomer of TV 3326, a ChE inhibitor with weak inhibitory activity against MAO-B.
(±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) V71615 (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) 2504-11-2 (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist/activator with cholinergic properties.
(±)Phenserine V108932 (±)Phenserine 159652-53-6 (±)benzylserine ((±)-benzylserine benzoate) is the racemic form of benzylserine.
1,1'-Bi-2-naphthol V122576 1,1'-Bi-2-naphthol 602-09-5 1,1'-Bi-2-naphthol is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 21.9 μM for human AChE.
1,10-Bis(pyridinium)decane V106966 1,10-Bis(pyridinium)decane 6266-40-6 1,10-Bis(pyridine)decane is an acetylcholinesterase (AchE) inhibitor with IC50 of 25.8nM.
1,2-Didehydrotanshinone IIA V103718 1,2-Didehydrotanshinone IIA 119963-50-7 1,2-Didehydrotanshinone IIA is a moderate inhibitor of AChE and BChE with IC50 of 5.98 μM for BChE.
2'-O-Succinyl-cAMP V71645 2'-O-Succinyl-cAMP 36940-87-1 2'-O-Succinyl-cAMP, a cAMP analog, can be covalently coupled to acetylcholinesterase.
2,3,9,10-Tetrahydroxyberberine bromide V124006 2,3,9,10-Tetrahydroxyberberine bromide 2847856-62-4 2,3,9,10-Tetrahydroxyberberine bromide is an acetylcholinesterase (AChE) inhibitor (IC50 = 7.8 μM).
2-Acetoxyacorenone V124414 2-Acetoxyacorenone 185154-95-4 2-Acetoxyacorenone is a sesquiterpene compound that can be isolated from the rhizome of Acorus gramineus.
2-Methyl-2-butenyl (E)-Caffeate V114739 2-Methyl-2-butenyl (E)-Caffeate 118971-61-2 2-Methyl-2-butenyl(E)-caffeic acid ester is a caffeic acid ester compound.
3-Acetylnerbowdine V125284 3-Acetylnerbowdine 100196-22-3 3-Acetylnerbowdine is an alkaloid.
3β-Hydroxy-lup-20(29)-en-16-one V71631 3β-Hydroxy-lup-20(29)-en-16-one 65043-60-9 3β-Hydroxy-lup-20(29)-en-16-one (compound 9) is a dual (bifunctional) inhibitor of AChE and BChE, with selectivity for BChE (IC50= 28.9 μM).
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