IAP (Inhibitor of Apoptosis) proteins, a family of anti-apoptotic proteins, play a crucial role in evading apoptosis because they have the ability to both block apoptosis-signaling pathways and promote survival. Eight members of this family (BIRC1/NAIP, BIRC2/cIAP1, BIRC3/cIAP2, BIRC4/XIAP, BIRC5/Survivin, BIRC6/Apollon, BIRC7/ML-IAP, and BIRC8/ILP2) have been identified in humans.
In determining the fate of a cell, IAP genes encode proteins that directly bind and inhibit caspases. Endogenous proteins (second mitochondrial activator of caspases and Omi) that are released from the mitochondria during apoptosis regulate the IAPs in turn. Members of the IAP protein family are frequently overexpressed in cancer and help tumor cells survive, resist chemotherapy, advance the disease, and have a poor prognosis. For the creation of new classes of cancer therapies, targeting important apoptosis regulators like IAPs is a tempting therapeutic approach.
IAPs have a significant impact on ubiquitin (Ub)-dependent pathways that modulate innate immune signaling by activating NF-B, though they are best known for their ability to control caspases. Several IAP family members influence cytokine production, signal transduction pathways, and cell survival to control innate and adaptive immunity. The function of cIAP1, cIAP2, and XIAP as ubiquitin ligases, whose targets have an impact on the NF-B and MAPK signaling pathways, is the primary mechanism by which the IAPs regulate immunity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0053 | AT406 (Xevinapant, SM406, ARRY334543) | 1071992-99-8 | Xevinapant (formerly Debio1143; AT-406; SM-406, ARRY-334543) is a first-in-class, orally bioavailable peptidomimetic of SMAC/DIABLO with potential antitumor activity. |
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V51577 | AZD-5582 dihydrochloride | 1883545-51-4 | inhibitor of apoptosis proteins (IAPs) |
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V4256 | AZD5582 | 1258392-53-8 | AZD5582 is a novel and potentIAP(Inhibitor of apoptosis proteins) antagonist which binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP withIC50s of 15, 21, and 15 nM, respectively. |
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V0051 | Birinapant (TL32711) | 1260251-31-7 | Birinapant (TL32711; TL-32711; TL 32711) is a novel and potent bivalent peptidomimetic ofSMAC (second mitochondrial-derived activator of caspases) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins. |
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V0055 | BV-6 | 1001600-56-1 | BV-6 is a novel and potent SMAC (second mitochondrial-derived activator of caspases)mimetic, and a dual inhibitor of cIAP (inhibitor of apoptosis) and XIAP (X-linked inhibitor of apoptosis) with potential anticancer activity. |
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V77134 | CST626 | CST626 (Compound 9) is a pan-IAP PROTAC degrader. | |
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V4532 | CUDC-427 (GDC-0917) | 1446182-94-0 | CUDC-427 (also known as GDC-0917) is a novel, potent,orally available, second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the treatment of various cancers. |
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V0054 | Embelin | 550-24-3 | Embelin is a naturally occuring quinone compound isolated from the Japanese Ardisia herb with anti-tumor and anti-inflammatory activity, acting as a potent andcell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) with IC50 of 4.1 μM in cell-free assays. |
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V0052 | GDC-0152 (RG7419) | 873652-48-3 | GDC-0152 (RG-7419) is a novel and potent antagonist of IAP (inhibitor of apoptosis) family proteins with antitumor activity. |
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V51572 | IAP Antagonist 1 | Lys-Covalent Inhibitor of Apoptosis Protein/IAP Antagonist | |
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V51573 | IAP Antagonist 2 | 2410953-19-2 | anti-cancer compound 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domain of XIAP, cIAP1, and cIAP2. |
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V0056 | LCL161 | 1005342-46-0 | LCL161 (LCL-161) is a novel and potent SMAC (second mitochondrial-derived activator of caspases)mimetic agent with potential anticancer activity, acting by potently binding to and inhibiting multiple IAP (inhibitor of apoptosis) proteins such as XIAP and c-IAP. |
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V51579 | SM-1295 | 1562375-46-5 | cIAP1 and cIAP2 inhibitor |
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V10594 | SM-164 | 957135-43-2 | SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins. |
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V76504 | SM-164 Hydrochloride | SM-164 HCl is a cell-permeable (penetrable) Smac analogue. | |
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V51578 | SM-433 | 1071992-81-8 | inhibitor of apoptosis proteins (IAPs) |
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V76503 | SM-433 hydrochloride | SM-433 hydrochlorid is a Smac mimetic that works as an inhibitor (blocker/antagonist) of inhibitory apoptosis proteins (IAPs). | |
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V76054 | XIAP BIR2/BIR2-3 inhibitor-1 | 1609384-59-9 | XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) is a dual (bifunctional) inhibitor of BIR2 and BIR2-3 with IC50 of 1.9 nM and 0.8 nM respectively. |
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V76053 | XIAP BIR2/BIR2-3 inhibitor-3 | 1434125-52-6 | XIAP BIR2/BIR2-3 inhibitor-3 is a dual (bifunctional) inhibitor of BIR2 and BIR2-3 with an IC 50s of less than 1 nM. |
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V51570 | XIAP degrader-1 | 2803617-91-4 | XIAP degrader-1 is a primary amine small molecule that promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP). |
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