IAP (Inhibitor of Apoptosis) proteins, a family of anti-apoptotic proteins, play a crucial role in evading apoptosis because they have the ability to both block apoptosis-signaling pathways and promote survival. Eight members of this family (BIRC1/NAIP, BIRC2/cIAP1, BIRC3/cIAP2, BIRC4/XIAP, BIRC5/Survivin, BIRC6/Apollon, BIRC7/ML-IAP, and BIRC8/ILP2) have been identified in humans.
In determining the fate of a cell, IAP genes encode proteins that directly bind and inhibit caspases. Endogenous proteins (second mitochondrial activator of caspases and Omi) that are released from the mitochondria during apoptosis regulate the IAPs in turn. Members of the IAP protein family are frequently overexpressed in cancer and help tumor cells survive, resist chemotherapy, advance the disease, and have a poor prognosis. For the creation of new classes of cancer therapies, targeting important apoptosis regulators like IAPs is a tempting therapeutic approach.
IAPs have a significant impact on ubiquitin (Ub)-dependent pathways that modulate innate immune signaling by activating NF-B, though they are best known for their ability to control caspases. Several IAP family members influence cytokine production, signal transduction pathways, and cell survival to control innate and adaptive immunity. The function of cIAP1, cIAP2, and XIAP as ubiquitin ligases, whose targets have an impact on the NF-B and MAPK signaling pathways, is the primary mechanism by which the IAPs regulate immunity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V128970 | Anticancer agent 294 | 1258392-56-1 | Anticancer agent 294 is an anticancer agent that has inhibitory activity against apoptosis inhibitor protein 1 (cIAP1) with an IC50 of 15 nM. |
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V129298 | Apoptosis inducer 61 | Apoptosis inducer 61 is an apoptosis inducer. | |
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V51577 | AZD-5582 dihydrochloride | 1883545-51-4 | inhibitor of apoptosis proteins (IAPs) |
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V4256 | AZD5582 | 1258392-53-8 | AZD5582 is a novel and potentIAP(Inhibitor of apoptosis proteins) antagonist which binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP withIC50s of 15, 21, and 15 nM, respectively. |
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V0055 | BV-6 | 1001600-56-1 | BV-6 is a novel and potent SMAC (second mitochondrial-derived activator of caspases)mimetic, and a dual inhibitor of cIAP (inhibitor of apoptosis) and XIAP (X-linked inhibitor of apoptosis) with potential anticancer activity. |
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V110311 | BV6 TFA | BV6 TFA is an antagonist of cIAP1 and XIAP, both of which belong to the inhibitory apoptosis protein (IAP) family. | |
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V77134 | CST626 | CST626 (Compound 9) is a pan-IAP PROTAC degrader. | |
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V4532 | CUDC-427 (GDC-0917) | 1446182-94-0 | CUDC-427 (also known as GDC-0917) is a novel, potent,orally available, second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the treatment of various cancers. |
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V0052 | GDC-0152 (RG7419) | 873652-48-3 | GDC-0152 (RG-7419) is a novel and potent antagonist of IAP (inhibitor of apoptosis) family proteins with antitumor activity. |
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V120137 | GDC-0152-acetamide | GDC-0152-acetamide is a pan-antagonist of inhibitory apoptosis protein (IAP). | |
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V136831 | GNE-1567 | GNE-1567 is a potent ERα PROTAC degrader and a selective XIAP antagonist with a Kd value of 0.03 μM. | |
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V137414 | HM90822 | 1363145-46-3 | HM90822 is an orally effective IAP antagonist. |
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V51572 | IAP Antagonist 1 | Lys-Covalent Inhibitor of Apoptosis Protein/IAP Antagonist | |
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V51573 | IAP Antagonist 2 | 2410953-19-2 | anti-cancer compound 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domain of XIAP, cIAP1, and cIAP2. |
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V137741 | IAP ligand 6 | IAP ligand 6 is an IAP ligand with a Ka value of 0.1 μM for the human XIAP BIR3 domain. | |
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V137742 | IAP ligand 7 | IAP ligand 7 is an E3 ligase ligand. | |
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V137743 | IAP ligand 8 | IAP ligand 8 is an ASX series non-peptide SMAC mimic and IAP binder with high cell permeability. | |
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V137744 | IAP ligand 9 | IAP ligand 9 is an ASX series non-peptide SMAC mimic and IAP binder with high cell permeability. | |
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V137745 | IAP ligand-Linker Conjugate 1 | IAP ligand-linker conjugate 1 is a ligand-linker conjugate targeting IAP that can be used in the synthesis of PROTAC TEAD1/IAP degrader-1. | |
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V116127 | KHS108-MV1 | KHS108-MV1 is a conjugate of KHS108 and MV1. |
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