All higher eukaryotes contain a transmembrane protein complex called Na+/K+ ATPase, which serves as a vital energy-intensive pump that keeps ionic and osmotic balance in cells. Na+/K+ ATPase is a newly discovered cancer target that needs more research.
For re-establishing and maintaining this gradient, the Na+/K+-ATPase (NKA, or Na+ pump) must always be active. The main NKA isoforms in cardiac and vascular smooth muscle are isoforms 1 and 2, and their physiological roles are regulated by both their distinct subcellular distribution and their individual and independent signaling pathways.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1919 | Chloroprocaine HCl | 3858-89-7 | Chloroprocaine HCl is a a potent, synthetic and local anesthetic used during surgical procedures. |
|
V74209 | Gitoxin | 4562-36-1 | Gitoxin is an inhibitor (blocker/antagonist) of Na+/K+-ATPase and a degradation metabolite of Digitoxin. |
|
V80318 | Prilocaine acetate | Prilocaine acetate is an aminoamide. | |
|
V4934 | Rostafuroxin (PST 2238) | 156722-18-8 | Rostafuroxin (formerlyPST2238; PST-2238) is an ouabain andNa/K-ATPase antagonist with antihypertensive activities. |
|
V50926 | Sodium oleate (Oleic acid sodium) | 143-19-1 | Sodium oleate (sodium oleate) is the most common monounsaturated fertilizer sodium salt found in human fat cells and other tissues. |
|
V74211 | SPAI-1 | 131359-77-8 | SPAI-1 is a specific inhibitor of monovalent cationic ATPase. |
|
V74208 | Stauntosaponin A (Stauntoside C) | 1417887-91-2 | Stauntosaponin A, a steroidal glycoside compound, is a potent Na(+)/K(+)-ATPase inhibitor (IC50=21 nM). |
|
V74210 | Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) | 888486-23-5 | Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a polypeptide consisting of 11 amino acid (AA)s, which can bind to Na+/K+-ATPase beta-subunit (ATP1B1) and mainly interacts with the C-terminus of ATP1B1. |
|
V76399 | Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) | Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a polypeptide consisting of 11 amino acid (AA)s that can bind to Na+/K+-ATPase beta-subunit (ATP1B1) and mainly interacts with the C-terminus of ATP1B1. |
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