PDI (Protein disulfide isomerases) is a 55-kDa protein and consists of four domains namely a, b, b', a'. The enzyme PDI is widely distributed in the endoplasmic reticulum (ER). A crucial oxidase, reductase, isomerase, and molecular chaperone is PDI, a model thiol isomerase. When proteins are folded in the ER, it can catalyze the formation and cleavage of thiol-disulfide bonds and distinguish between substrates that are partially folded, unfolded, and properly folded. Additionally, PDI can stabilize the class 1 peptide loading complex (PLC) of the major histocompatibility complex (MHC) and preserve the active conformation of the collagen prolyl 4-hydroxylase's subunit. PDI expression is increased in some cancer types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V112347 | 3-N-Propylphenol | 621-27-2 | 3-n-Propylphenol is a small molecule phenolic derivative containing a hydroxy aryl group. It can competitively inhibit the binding of peptides to pancreatic-specific protein disulfide isomerase (PDIp). |
|
V9527 | 3-Methyltoxoflavin | 32502-62-8 | 3-Methyltoxoflavin is a novel inhibitor of Hsp90. |
|
V51896 | KSC-34 | 2226201-97-2 | KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1) and is a potent PDIA1 a site-selective inhibitor (antagonist) with IC50 of 3.5 μM. |
|
V22865 | LOC14 | 877963-94-5 | LOC14 (LOC-14) is a high affinity protein disulfide isomerase (PDI) modulator (Kd = 62 nM). |
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V27064 | PACMA 31 | 1401089-31-3 | PACMA 31 (PACMA31; PACMA-31) is a novel, orally bioavailable, and covalent/irreversible inhibitor of protein disulfide isomerase (PDI) with potentian anticancer activity. |
|
V88740 | PDI-IN-2 | PDI-IN-2 (Compound 22) is a PDI or recombinant PDI inhibitor with IC50 values of 0.62 and 0.63 μM, respectively. | |
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V119120 | PDIA1-IN-1 | PDIA1-IN-1 is an inhibitor of protein disulfide isomerase 1 (PDIA1). | |
|
V118271 | PROTAC PDIA1 degrader 1 | 3024292-21-2 | PROTAC PDIA1 degrader 1 (compound H4) is a PDIA1 PROTAC degrader with a DC50 value of 29.71 μM. |
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