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CETP

CETP

Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters from atheroprotective high density lipoprotein (HDL) to proatherogenic low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL), resulting in lower levels of HDL but higher levels of proatherogenic LDL and VLDL. A class of medications known as CETP inhibitors targets the CETP enzyme to significantly raise serum HDL-C and lower LDL-C levels. An option for treating dyslipidemia is thought to be CETP inhibition.
Both alternative splicing and single-base polymorphisms can affect the level of CETP activity. There have been reports linking various common CETP variants to changes in plasma lipid levels, CAD risk, and/or CETP mass/activity. The phenotypic variation of HDL-C in the general population is also influenced by the uncommon genetic variations in the CETP gene.

CETP related products

Structure Cat No. Product Name CAS No. Product Description
CETP-IN-4 V73925 CETP-IN-4 1648889-70-6 CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.
DRL17822 V83269 DRL-17822 898911-09-6 DRL-17822 is a novel and potent Cholesteryl Ester Transfer Protein (CETP) inhibitor.
Evacetrapib (LY2484595) V0913 Evacetrapib (LY2484595) 1186486-62-3 Evacetrapib (also known as LY-2484595; LY2484595),abenzazepine compound,isa potent and selective inhibitor of CETP(Cholesteryl ester transfer protein)with the potential to lower cholesterol levels and toprevent cardiovascular diseases.
安塞曲匹 V0911 Anacetrapib (MK-0859) 875446-37-0 Anacetrapib (formerly also known as MK0859; MK-0859), apoly-fluorinatedlipophiliccompound, is a selective and reversible inhibitor of CETP (Cholesteryl ester transfer protein) and mutant CETP(C13S) with the potential to treat cardiovascular disease.
托彻普 V0912 Torcetrapib 262352-17-0 Torcetrapib (formerly CP 529414; CP-529,414;CP-529414) is a novel and potent CETP(Cholesteryl ester transfer protein) inhibitor with the potential to lower cholesterol levels and totreatcardiovascular diseases.
达塞曲匹 V0914 Dalcetrapib (JTT-705, RO4607381) 211513-37-0 Dalcetrapib (formerly JTT-705;RO-4607381; JTT705;RO4607381) is a novel, potent and selectiveinhibitor of CETP (Cholesteryl ester transfer protein) with the potential to prevent cardiovascular diseases.
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