Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters from atheroprotective high density lipoprotein (HDL) to proatherogenic low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL), resulting in lower levels of HDL but higher levels of proatherogenic LDL and VLDL. A class of medications known as CETP inhibitors targets the CETP enzyme to significantly raise serum HDL-C and lower LDL-C levels. An option for treating dyslipidemia is thought to be CETP inhibition.
Both alternative splicing and single-base polymorphisms can affect the level of CETP activity. There have been reports linking various common CETP variants to changes in plasma lipid levels, CAD risk, and/or CETP mass/activity. The phenotypic variation of HDL-C in the general population is also influenced by the uncommon genetic variations in the CETP gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0911 | Anacetrapib (MK-0859) | 875446-37-0 | Anacetrapib (formerly also known as MK0859; MK-0859), apoly-fluorinatedlipophiliccompound, is a selective and reversible inhibitor of CETP (Cholesteryl ester transfer protein) and mutant CETP(C13S) with the potential to treat cardiovascular disease. |
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V73925 | CETP-IN-4 | 1648889-70-6 | CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor. |
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V0914 | Dalcetrapib (JTT-705, RO4607381) | 211513-37-0 | Dalcetrapib (formerly JTT-705;RO-4607381; JTT705;RO4607381) is a novel, potent and selectiveinhibitor of CETP (Cholesteryl ester transfer protein) with the potential to prevent cardiovascular diseases. |
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V83269 | DRL-17822 | 898911-09-6 | DRL-17822 is a novel and potent Cholesteryl Ester Transfer Protein (CETP) inhibitor. |
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V0913 | Evacetrapib (LY2484595) | 1186486-62-3 | Evacetrapib (also known as LY-2484595; LY2484595),abenzazepine compound,isa potent and selective inhibitor of CETP(Cholesteryl ester transfer protein)with the potential to lower cholesterol levels and toprevent cardiovascular diseases. |
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V0912 | Torcetrapib | 262352-17-0 | Torcetrapib (formerly CP 529414; CP-529,414;CP-529414) is a novel and potent CETP(Cholesteryl ester transfer protein) inhibitor with the potential to lower cholesterol levels and totreatcardiovascular diseases. |
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