HIV integrase is one of the three key enzymes of the pol gene of HIV. The retrotranscription-produced viral DNA is inserted into the human cell that has been infected by HIV using the HIV integrase enzyme. The development of new therapeutics for the treatment of AIDS is attracted to this particular stage in the virus life cycle because it offers a variety of points for intervention. Both HIV-1 and HIV-2 integrases are part of the HIV family.
DNA integration is carried out by the 32-kDa HIV-1 integrase in a two-step reaction. Two nucleotides are removed from each 3′ end of the viral DNA created by reverse transcription in the first step, known as 3′ processing. The ends of the viral DNA are integrated into the host genome in the following procedure, known as DNA strand transfer, by means of two transesterification reactions. The three structurally and functionally separate domains that make up integrase are necessary for each stage of the integration reaction.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V106553 | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide | 174899-83-3 | |
|
V87516 | 2-Hydroxyisoquinoline-1,3(2H,4H)-dione | 6890-08-0 | Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a potent inhibitor of HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) with IC50 values of 6.32 and 5.9 µM, respectively. |
|
V53377 | BDM-2 | 1643876-33-8 | BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN) (IC50=47 nM) and has potent antiretroviral (ARV) activity. |
|
V87513 | Bictegravir-d4 | Bictegravir-d4 is a deuterated derivative of Bictegravir. | |
|
V79650 | Dihydrobionin B | Dihydroobionin B is a potent HIV-1 Integrase inhibitor. | |
|
V87511 | Dihydroobionin B | Dihydroobionin B is a potent HIV-1 Integrase inhibitor. | |
|
V99846 | GSK-364735 | 863434-13-3 | GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and an integrase inhibitor with an IC50 of 8 ± 2 nM. |
|
V104582 | GSK-364735 potassium | 912672-93-6 | |
|
V104583 | GSK-364735 sodium | 863437-78-9 | |
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V72003 | GSK3839919A | 2081127-77-5 | GSK3839919A is a potent HIV-1 integrase inhibitor. |
|
V87512 | HIV-1 integrase inhibitor 11 | 54030-51-2 | HIV-1 integrase inhibitor 11 (compound 5) is a potent inhibitor of HIV-1 integrase with IC50 of 125 μM. |
|
V87514 | HIV-1 integrase inhibitor 12 | HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor of HIV-1 integrase with IC50 of 1.4 nM. | |
|
V87509 | HIV-1 integrase inhibitor 13 | HIV-1 integrase inhibitor 13 (Compound 15) is an inhibitor of HIV-1 integrase with IC50 of 1.8 nM. | |
|
V72005 | HIV-1 integrase inhibitor 8 | 1568-80-5 | HIV-1 integrase inhibitor 8 is an HIV-1 integrase (HIV-1 integrase) inhibitor, compound 8. |
|
V98954 | IN-RNA-IN-2 | IN-RNA-IN-2 (compound 1a) is an inhibitor of the interaction between HIV-1 integrase and the viral RNA genome (IC50=70 nM). | |
|
V72004 | XZ426 | 1638504-52-5 | XZ426 is a potent integrase strand transfer inhibitor (antagonist) with anti-HIV (Human Immunodeficiency Virus) activity. |
|
V4329 | Raltegravir potassium (MK-0518) | 871038-72-1 | Raltegravir potassium (formerly also known as MK-0518 potassium; trade name: Isentress) is a novel, potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. |
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