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Androgen Receptor

Androgen Receptor

The nuclear receptor known as the androgen receptor (AR) is activated when either the androgenic hormones testosterone or dihydrotestosterone bind to it in the cytoplasm before moving into the nucleus. The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in higher doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The development and maintenance of the male sexual phenotype depend heavily on genes that are regulated by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.

Androgen Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(+)-JJ-74-138 V98841 (+)-JJ-74-138 2135545-34-3 (+)-JJ-74-138 is a novel noncompetitive androgen receptor (AR) antagonist that inhibits enzalutamide-resistant castration-resistant prostate cancer (CRPC).
(-)-Erteberel V89087 (-)-Erteberel 533884-08-1 (-)-Erteberel is a selective estrogen receptor β (ERβ) agonist.
(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol V89074 (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol 1393651-00-7 (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity.
(R,R)-THC V89081 (R,R)-THC 221368-54-3 (R,R)-THC is an ERα agonist and ERβ antagonist, with Ki values of 9.0 nM and 3.6 nM for ERα and ERβ, respectively.
17-Epiestriol V89083 17-Epiestriol 1228-72-4 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist.
AC-262536 V8411 AC-262536 870888-46-3 AC-262536 (AC262536) is anovel selective androgen receptor modulator (SARM) with beneficial anabolic effects.
ACP-105 V10225 ACP-105 899821-23-9 ACP-105 (ACP105; ACP 105) is a novel, nonsteroidal and orally bioactive SARM (selective androgen receptor modulator) that has been investigated for the treatment of age-related cognitive decline.
Andarine (GTx-007) V1761 Andarine (GTx-007) 401900-40-1 Andarine (formerly known as GTx-007;S-4;GTx007;S4) is an orally bioactive and selective non-steroidal androgen receptor (AR) agonist,specifically a selective androgen receptor modulator (SARM),that has potential usefulness in muscle wasting and osteoporosis.
Androgen receptor antagonist 10 V88175 Androgen receptor antagonist 10 876759-87-4 Androgen receptor antagonist 10 (compound 6h) is an androgen receptor antagonist.
Androgen receptor antagonist 12 V93122 Androgen receptor antagonist 12 6605-17-0 Androgen receptor antagonist 12 (Compound EF2) is an orally active androgen receptor (AR) antagonist (IC50: 0.30 μM).
Androgen receptor degrader-4 V85279 Androgen receptor degrader-4 2505495-83-8
Androgen receptor degrader-5 V98995 Androgen receptor degrader-5 2902679-11-0 Androgen receptor degrader-5 (compound 14k) exhibits favorable properties, including excellent androgen receptor (AR) degradation activity and antiproliferative activity.
Androgen receptor-IN-3 V89078 Androgen receptor-IN-3 926228-58-2 Androgen Receptor-IN-3 (Compound 22) is an androgen receptor inhibitor.
Androgen receptor-IN-4 V88176 Androgen receptor-IN-4 2759137-87-4 Androgen Receptor-IN-4 (Compound 206) is an androgen receptor inhibitor that can be used in the study of Kennedy's disease.
AR antagonist 5 V85093 AR antagonist 5 2902679-53-0
AR antagonist 6 V88172 AR antagonist 6 876760-08-6 AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds to AR at a concentration of 120 nM.
AR antagonist 7 V89070 AR antagonist 7 876759-97-6 AR antagonist 7 (86) is an androgen receptor (AR) antagonist that can be used in the study of hair loss.
AR antagonist 8 V89068 AR antagonist 8 AR antagonist 8 (compound 16) is ethinylestradiol, a potent Lupeol-inspired androgen receptor (AR) antagonist with IC50 of 0.76 μM.
AR Degrader-1 V88174 AR Degrader-1 AR Degrader-1 is a monovalent androgen receptor (AR) degrader.
AR Degrader-2 V89066 AR Degrader-2 3023359-76-1 AR Degrader-2 (Compound 2) is a degrader of androgen receptor (AR) with a DC50 of 0.3-0.5 μM in VCaP cells.
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