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Androgen Receptor

Androgen Receptor

The nuclear receptor known as the androgen receptor (AR) is activated when either the androgenic hormones testosterone or dihydrotestosterone bind to it in the cytoplasm before moving into the nucleus. The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in higher doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The development and maintenance of the male sexual phenotype depend heavily on genes that are regulated by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.

Androgen Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(+)-JJ-74-138 V98841 (+)-JJ-74-138 2135545-34-3 (+)-JJ-74-138 is a novel noncompetitive androgen receptor (AR) antagonist that inhibits enzalutamide-resistant castration-resistant prostate cancer (CRPC).
(-)-Erteberel V89087 (-)-Erteberel 533884-08-1 (-)-Erteberel is a selective estrogen receptor β (ERβ) agonist.
(–)-JJ-450 V121145 (–)-JJ-450 1998094-23-7 (–)-JJ-450 is a non-competitive androgen receptor (AR) antagonist.
(3R,3′R)-Astaxanthin V121529 (3R,3′R)-Astaxanthin 60760-95-4 (3R,3′R)-Astaxanthin is an androgen receptor binding agent.
(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol V89074 (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol 1393651-00-7 (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity.
(R,R)-THC V89081 (R,R)-THC 221368-54-3 (R,R)-THC is an ERα agonist and ERβ antagonist, with Ki values of 9.0 nM and 3.6 nM for ERα and ERβ, respectively.
(rel)-BMS-641988 V122053 (rel)-BMS-641988 573738-99-5 (rel)-BMS-641988 is a relative configuration of BMS-641988.
17-Epiestriol V89083 17-Epiestriol 1228-72-4 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist.
19-Noretiocholanolone V102591 19-Noretiocholanolone 33036-33-8 19-Norepinephrine is an androgenic steroid metabolite.
2-(2-Methoxyphenoxy)ethylamine hydrochloride V123798 2-(2-Methoxyphenoxy)ethylamine hydrochloride 64464-07-9 2-(2-Methoxyphenoxy)ethylamine hydrochloride is a mixed agonist/antagonist.
3'-Hydroxy stanozolol V125392 3'-Hydroxy stanozolol 125709-39-9 3'-Hydroxy stanozolol is the main metabolite of the anabolic androgenic steroid stanozolol.
3-Cl-Pyridine-amide-acrylaldehyde-piperazine V125335 3-Cl-Pyridine-amide-acrylaldehyde-piperazine 3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate for LO-4-25.
3-Oxochol-5-en-24-oic acid V114726 3-Oxochol-5-en-24-oic acid 847232-54-6 3-O-5-en-24-acid is a rare bile acid produced by gut microbiota.
3βHSD1-IN-1 V125667 3βHSD1-IN-1 3082852-63-6 3βHSD1-IN-1 is an inhibitor of 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) with an IC50 value of 55 nM.
4-AcO-DALT hydrochloride V126133 4-AcO-DALT hydrochloride 4-AcO-DALT hydrochloride is a tryptamine compound with psychoactive effects.
6-Amino-5-bromoquinoxaline V127278 6-Amino-5-bromoquinoxaline 50358-63-9 6-Amino-5-bromoquinoxaline is a 2-(arylamino)imidazole derivative and a precursor for α1- and α2-androgen receptor antagonists.
6α-Chloro testosterone V107122 6α-Chloro testosterone 847674-32-2 6α-Chlorotestosterone is a metabolizable androgenic steroid.
6α-Hydroxy metandienone V102630 6α-Hydroxy metandienone 55720-48-4 6α-Hydroxyandrostenedione is the androgenic anabolic steroid metabolite of androstenedione.
AC-262536 V8411 AC-262536 870888-46-3 AC-262536 (AC262536) is anovel selective androgen receptor modulator (SARM) with beneficial anabolic effects.
ACP-105 V10225 ACP-105 899821-23-9 ACP-105 (ACP105; ACP 105) is a novel, nonsteroidal and orally bioactive SARM (selective androgen receptor modulator) that has been investigated for the treatment of age-related cognitive decline.
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