Syk

Syk

Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.

Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).

Syk related products

Structure Cat No. Product Name CAS No. Product Description
V2698 BAY-61-3606 732983-37-8 BAY-61-3606 (BAY 61-3606, BAY 61-3606), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with Ki of 7.5 nM.
V2676 BAY-61-3606 dihydrochloride 648903-57-5 BAY-61-3606 2HCl (BAY 61-3606, BAY 61-3606 dihydrochloride), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with immunomodulatory effects.
V69780 Cevidoplenib dimesylate (SKI-O-703 dimesylate) 2043659-93-2
V69784 Dehydroabietinol 3772-55-2
V3898 Fostamatinib disodium hexahydrate 914295-16-2 Fostamatinib disodium hexahydrate (formerly R-935788; R 935788; R-788; R788; trade name:Tavalisse) is the disodium salt and hexa-hydrated form of Fostamatinib which is a prodrug of the active metabolite R406.
V11698 Gusacitinib (ASN002) 1425381-60-7 Gusacitinib (formerly known as EN-3351;ASN-002)is a novle and potent dual inhibitor of SYK/JAK (spleen tyrosine kinase/janus kinase) withantitumor activity in both hematological and solid tumor xenograft models.
V40855 Lanraplenib succinate (GS9876; GS-SYK) 1800047-00-0 Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50of 9.5 nM).
V2679 PRT-060318 3HCl 1194961-19-7 PRT-060318 3HCl (also known as PRT318 3HCl) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
V5244 R112 575474-82-7 R112 is a novel, potent and ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM.
V2673 RO9021 1446790-62-0 RO9021 (RO-9021) is a potent, orally bioavailavle, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with usefulness in autoimmune disease therapy, such as arthritis.
V3854 Syk Inhibitor II 726695-51-8 Syk inhibitor II, a pyrimidine-carboxamide analog, is a novel potent, cell-permeable, ATP-competitive inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase that selectively and reversibly inhibits Syk with IC50 of 41 nM.
V69782 Syk Kinase Peptide Substrate 865778-47-8
V81486 Syk Kinase Peptide Substrate, Biotin labeled
V69781 Syk-IN-4 2932264-95-2
V78691 Syk-IN-7
V69779 Syk-IN-8 2568963-01-7
V2782 TAK-659 HCl 1952251-28-3 TAK-659 (TAK659) hydrochloride is a novel, potent, highly selective and orally bioavailable spleen tyrosine kinase (Syk) inhibitor (IC50 = 3.2 nM) with the potential for the treatment of chronic lymphocytic leukemia (CLL).
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