Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.
Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2698 | BAY-61-3606 | 732983-37-8 | BAY-61-3606 (BAY 61-3606, BAY 61-3606), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with Ki of 7.5 nM. |
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V2676 | BAY-61-3606 dihydrochloride | 648903-57-5 | BAY-61-3606 2HCl (BAY 61-3606, BAY 61-3606 dihydrochloride), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with immunomodulatory effects. |
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V69780 | Cevidoplenib dimesylate (SKI-O-703 dimesylate) | 2043659-93-2 | Cevidoplenib is an orally bioactive splenic tyrosine kinase (Syk) inhibitor (antagonist) with potential anti~inflammatory and Immune-modulatory effects. |
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V69784 | Dehydroabietinol | 3772-55-2 | Dehydroabietinol is a rosinane diterpenoid. |
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V3898 | Fostamatinib disodium hexahydrate | 914295-16-2 | Fostamatinib disodium hexahydrate (formerly R-935788; R 935788; R-788; R788; trade name:Tavalisse) is the disodium salt and hexa-hydrated form of Fostamatinib which is a prodrug of the active metabolite R406. |
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V11698 | Gusacitinib (ASN002) | 1425381-60-7 | Gusacitinib (formerly known as EN-3351;ASN-002)is a novle and potent dual inhibitor of SYK/JAK (spleen tyrosine kinase/janus kinase) withantitumor activity in both hematological and solid tumor xenograft models. |
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V40855 | Lanraplenib succinate (GS9876; GS-SYK) | 1800047-00-0 | Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50of 9.5 nM). |
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V2679 | PRT-060318 3HCl | 1194961-19-7 | PRT-060318 3HCl (also known as PRT318 3HCl) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
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V5244 | R112 | 575474-82-7 | R112 is a novel, potent and ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. |
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V2673 | RO9021 | 1446790-62-0 | RO9021 (RO-9021) is a potent, orally bioavailavle, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with usefulness in autoimmune disease therapy, such as arthritis. |
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V3854 | Syk Inhibitor II | 726695-51-8 | Syk inhibitor II, a pyrimidine-carboxamide analog, is a novel potent, cell-permeable, ATP-competitive inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase that selectively and reversibly inhibits Syk with IC50 of 41 nM. |
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V69782 | Syk Kinase Peptide Substrate | 865778-47-8 | Syk Kinase Peptide Substrate is a Syk kinase peptide substrate. |
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V81486 | Syk Kinase Peptide Substrate, Biotin labeled | Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labeled, Syk kinase peptide substrate. | |
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V69781 | Syk-IN-4 | 2932264-95-2 | Syk-IN-4 is a potent, orally bioactive and selective SYK inhibitor (antagonist) with IC50 of 0.31 nM. |
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V78691 | Syk-IN-7 | Syk-IN-7 (compound 17) is a spleen tyrosine kinase (SYK) inhibitor. | |
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V69779 | Syk-IN-8 | 2568963-01-7 | Syk-IN-8 (compound 19q) is a Syk inhibitor (antagonist) with antiproliferation activity against a variety of hematological tumor cells. |
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V2782 | TAK-659 HCl | 1952251-28-3 | TAK-659 (TAK659) hydrochloride is a novel, potent, highly selective and orally bioavailable spleen tyrosine kinase (Syk) inhibitor (IC50 = 3.2 nM) with the potential for the treatment of chronic lymphocytic leukemia (CLL). |
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