Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.
Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V111571 | (rel)-PRT062607 | 1194954-52-3 | (rel)-PRT062607 ((rel)-P505-15) is the relative configuration of PRT062607. |
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V129486 | As48 | 1214405-38-5 | As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assays. |
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V88080 | Asebogenin | 520-42-3 | Asebogenin has anti-malarial activity in vitro. |
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V2698 | BAY-61-3606 | 732983-37-8 | BAY-61-3606 (BAY 61-3606, BAY 61-3606), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with Ki of 7.5 nM. |
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V2676 | BAY-61-3606 dihydrochloride | 648903-57-5 | BAY-61-3606 2HCl (BAY 61-3606, BAY 61-3606 dihydrochloride), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with immunomodulatory effects. |
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V130129 | BI 894416 | 1810059-82-5 | BI 894416 is a spleen tyrosine kinase (SYK) inhibitor. |
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V69780 | Cevidoplenib dimesylate (SKI-O-703 dimesylate) | 2043659-93-2 | Cevidoplenib is an orally bioactive splenic tyrosine kinase (Syk) inhibitor (antagonist) with potential anti~inflammatory and Immune-modulatory effects. |
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V133300 | DBMB | 314027-66-2 | DBMB is a spleen tyrosine kinase (Syk) inhibitor that can significantly inhibit the activity of Syk kinase. |
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V69784 | Dehydroabietinol | 3772-55-2 | Dehydroabietinol is a rosinane diterpenoid. |
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V136985 | GT103 | GT103 is a human monoclonal antibody that targets complement factor H (CFH). | |
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V137762 | Ibt-DOX | Ibt-DOX is a BTK inhibitor with an IC50 value of 2.89 nM. | |
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V115509 | IQS-019 | 1630804-24-8 | IQS-019 is a B cell receptor (BCR) kinase inhibitor. |
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V88079 | MK-8457 | 1312518-84-5 | MK-8457 is a dual SYK/ZAP70 inhibitor. |
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V140486 | MTX-216 | 1952236-19-9 | MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. |
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V88078 | NMS-0963 | 2765304-82-1 | NMS-0963 (compound 1) is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 3 nM. |
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V2680 | PRT-060318 | 1194961-19-7 | PRT-060318 (also known as PRT318) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
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V2679 | PRT-060318 3HCl | 1194961-19-7 | PRT-060318 3HCl (also known as PRT318 3HCl) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
|
V112026 | PRT-060318 dihydrochloride | 3032567-93-1 | PRT-060318 (PRT318) dihydrochloride is a potent, selective, and orally effective tyrosine kinase Syk inhibitor with an IC50 of 3 nM. |
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V0652 | PRT062607 (P505-15, BIIB057) HCl | 1370261-97-4 | PRT062607 (also known as P505-15, BIIB-057) HCl is a novel, potent, highly selective and orally bioavailablesmall molecule Syk inhibitor with potential anti-inflammatory activity. |
|
V5244 | R112 | 575474-82-7 | R112 is a novel, potent and ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. |
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