Syk

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Syk

Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.

Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).

Syk related products

Cat No.	Product Name	CAS No.	Product Description
V2698	BAY-61-3606	732983-37-8	BAY-61-3606 (BAY 61-3606, BAY 61-3606), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with Ki of 7.5 nM.
V2676	BAY-61-3606 dihydrochloride	648903-57-5	BAY-61-3606 2HCl (BAY 61-3606, BAY 61-3606 dihydrochloride), cell-permeable imidazopyrimidine compound, is a potent and selective, oral, ATP-competitive, reversible inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase with immunomodulatory effects.
V69780	Cevidoplenib dimesylate (SKI-O-703 dimesylate)	2043659-93-2	Cevidoplenib is an orally bioactive splenic tyrosine kinase (Syk) inhibitor (antagonist) with potential anti~inflammatory and Immune-modulatory effects.
V69784	Dehydroabietinol	3772-55-2	Dehydroabietinol is a rosinane diterpenoid.
V2679	PRT-060318 3HCl	1194961-19-7	PRT-060318 3HCl (also known as PRT318 3HCl) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
V5244	R112	575474-82-7	R112 is a novel, potent and ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM.
V2673	RO9021	1446790-62-0	RO9021 (RO-9021) is a potent, orally bioavailavle, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with usefulness in autoimmune disease therapy, such as arthritis.
V69782	Syk Kinase Peptide Substrate	865778-47-8	Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.
V81486	Syk Kinase Peptide Substrate, Biotin labeled		Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labeled, Syk kinase peptide substrate.
V69781	Syk-IN-4	2932264-95-2	Syk-IN-4 is a potent, orally bioactive and selective SYK inhibitor (antagonist) with IC50 of 0.31 nM.
V78691	Syk-IN-7		Syk-IN-7 (compound 17) is a spleen tyrosine kinase (SYK) inhibitor.
V69779	Syk-IN-8	2568963-01-7	Syk-IN-8 (compound 19q) is a Syk inhibitor (antagonist) with antiproliferation activity against a variety of hematological tumor cells.
V3854	Syk Inhibitor II	726695-51-8	Syk inhibitor II, a pyrimidine-carboxamide analog, is a novel potent, cell-permeable, ATP-competitive inhibitor of Syk (Spleen tyrosine kinase) tyrosine kinase that selectively and reversibly inhibits Syk with IC50 of 41 nM.
V2782	TAK-659 HCl	1952251-28-3	TAK-659 (TAK659) hydrochloride is a novel, potent, highly selective and orally bioavailable spleen tyrosine kinase (Syk) inhibitor (IC50 = 3.2 nM) with the potential for the treatment of chronic lymphocytic leukemia (CLL).
V3898	Fostamatinib disodium hexahydrate	914295-16-2	Fostamatinib disodium hexahydrate (formerly R-935788; R 935788; R-788; R788; trade name:Tavalisse) is the disodium salt and hexa-hydrated form of Fostamatinib which is a prodrug of the active metabolite R406.
V11698	Gusacitinib (ASN002)	1425381-60-7	Gusacitinib (formerly known as EN-3351;ASN-002)is a novle and potent dual inhibitor of SYK/JAK (spleen tyrosine kinase/janus kinase) withantitumor activity in both hematological and solid tumor xenograft models.
V40855	Lanraplenib succinate (GS9876; GS-SYK)	1800047-00-0	Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50of 9.5 nM).