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HDAC

HDAC

HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Structure Cat No. Product Name CAS No. Product Description
4-碘伏立诺他 V41465 4-iodo-SAHA 1219807-87-0 4-Iodo-SAHA (1k) is a class I and class II histone deacetylase (HDAC) inhibitor (antagonist) with EC50s of 1.1, 0.95, 0.12, 0.24, and 0.85 for Skbr3, HT29, U937, JA16, and HL60 cells, respectively.
4-苯基丁酸钠盐 V0284 Sodium Phenylbutyrate (4-PBA sodium) 1716-12-7 Sodium phenylbutyrate (4-Phenylbutyric acid sodium; 4-PBA sodium),an orphan drug marketed by Ucyclyd Pharma, is a novel and potent histone deacetylase (HDAC) inhibitor used as an as adjunctive therapy for chronic treatment of urea cycle disorders involving deficiencies of argininosuccinic acid synthetase (AS), ornithine transcarbamylase (OTC), or carbamylphosphate synthetase (CPS).
4SC-202 V0264 Domatinostat (4SC202) 910462-43-0 Domatinostat (formerly 4SC-202)is a novel, potent, and orally bioavailable benzamide-based Class I HDAC inhibitor with potential anticancer activity.
ACY-738 V2907 ACY-738 1375465-91-0 ACY-738 (ACY738) is a novel, potent, selective, brain penetrable and orally-bioavailable HDAC6 inhibitor with neuroprotective and anticancer activities.
Antitumor agent-123 V78075 Antitumor agent-123 Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects such as JAK2, JAK3, HDAC1 and HDAC6, with IC50s of 34.6 and 2.6 μM for JAK2 and JAK3, respectively.
AR-42 抑制剂 V0283 AR-42 (HDAC-42, NSC-736012, OSU-42) 935881-37-1 AR-42 (HDAC-42, NSC-736012, OSU-42 etc.) is a novel and potent histone deacetylase (HDAC) inhibitor with potential antitumor activity. At 30 nM, its IC50 inhibits HDAC.
BG45 V0262 BG45 926259-99-6 BG45 (BG-45) is a novel, potent and selective class I HDAC inhibitor with potential anticancer activity.
BRD 4354 ditrifluoroacetate V78544 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is an inhibitor (blocker/antagonist) of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM respectively.
BRD3308 V16989 BRD3308 1550053-02-5 BRD3308 is a selective HDAC3 inhibitor (antagonist) with IC50 of 54 nM.
BRD73954 V0263 BRD73954 1440209-96-0 BRD73954 (BRD-73954) is a novel, potent and dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 with potential anticancer activity.
CAY10603 V0267 CAY10603 1045792-66-2 CAY10603 is a novel, potent and selective HDAC6 (Histone deacetylase) inhibitor with potential anticancer activity and a potential to treatneurodegenerative diseases.
CAY10683 (Santacruzamate A) V2867 CAY10683 (Santacruzamate A) 1477949-42-0 Santacruzamate A (also known as CAY10683) is a potent and selective inhibitor of HDAC (histone deacetylase) with IC50 of 119 pM for HDAC2, it exhibits >3600-fold selectivity over other HDACs.
CUDC-101 V0277 CUDC-101 1012054-59-9 CUDC-101 is a novel, potent and multi-targeted histone deacetylase (HDAC) inhibitor with potential anticancer activity.
Domatinostat HCl V3847 Domatinostat HCl Domatinostat HCl (formerly 4SC202; 4SC-202), the hydrochloride salt ofDomatinostat, is a class I HDAC inhibitor (HDACi) with potential anticancer activity.
Elevenostat V50034 Elevenostat 1454902-97-6 Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235 µM).
GK444 V78109 GK444 3032392-39-2 GK444 (Compound 15a) is an HDAC1/2 inhibitor (IC50= 100 and 92 nM for HDAC1/2, respectively).
GK718 V78703 GK718 GK718 is an HDAC1/3 inhibitor (IC50= 259 and 139 nM, respectively).
HDAC-IN-47 V79732 HDAC-IN-47 HDAC-IN-47 is an orally bioactive histone deacetylase (HDAC) inhibitor (antagonist) with IC50s of 19.75 nM (HDAC1), 5.63 nM (HDAC6), 40.27 nM (HDAC3), and 57.8 nM (HDAC2).
HDAC-IN-49 V78726 HDAC-IN-49 HDAC-IN-49 is a potent, non-selective HDAC (HDAC) inhibitor (antagonist) with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 respectively.
HDAC-IN-61 V78539 HDAC-IN-61 HDAC-IN-61 (compound 12k) is an orally bioavailable HDAC inhibitor.
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