PKC

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PKC

Protein kinase C (PKC) is a family of protein kinase enzymes that play a role in regulating the activity of other proteins by phosphorylating the hydroxyl groups on serine and threonine amino acid residues. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes are crucial components of numerous signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.

PKC related products

Cat No.	Product Name	CAS No.	Product Description
V4878	CMPD-101	865608-11-3	CMPD101 is a novel, potent and selective inhibitor of G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) with IC50 values of 35 and 32 nM for GRK2 and GRK3, respectively.
V33467	D-erythro-Sphingosine (Erythrosphingosine)	123-78-4	D-erythro-Sphingosine(Erythrosphingosine) is a highly potent activator of p32-kinase with an EC50 of 8 μM.
V3649	Darovasertib (LXS-196; IDE-196)	1874276-76-2	Darovasertib (LXS196; IDE196) is a novel, potent, selective and orally bioactive inhibitor of protein kinase C (PKC)with anticancer activity.
V67538	PKC beta pseudosubstrate	172308-76-8	PKC β pseudosubstrate is a selective, cell-penetrable PKC inhibitor.
V2030	PKC-theta inhibitor	736048-65-0	PKC-theta inhibitor is a novel, potent and selective PKC-θ inhibitor with anIC50of 12 nM.
V25200	PKC-theta inhibitor hcl	2253640-49-0	PKC-theta inhibitor HCl is a novel and potent PKC-θ inhibitor
V27043	PKCß inhibitor	257879-35-9	PKCß inhibitor, ananilino-monoindolylmaleimide compound, is a novel, potent,ATP-competitive and selective inhibitor of PKCß isozymes.
V67537	PKCβII Peptide Inhibitor I	862502-26-9	PKCβII Peptide Inhibitor I is a PKCβII inhibitor.
V67539	PKCδ Peptide Substrate	813416-46-5	PKCδ Peptide Substrate is an absolutely specific substrate for δ-type PKC, and its sequence corresponds to the mouse eEF-1α sequence 422-443 containing Thr-431.
V67535	PKCε (85-92)	207111-98-6	PKCε (85-92) is a biologically active peptide.
V67536	PKCη pseudosubstrate inhibitor,myristoylated	908012-19-1	PKCη pseudosubstrate inhibitor, myristoylated is cell permeable/penetrable and may be utilized to study the mechanism of action of PKCη.
V16673	TPPB	497259-23-1	TPPB is a novel, potent and cell-permeable benzolactam-derived protein kinase C (PKC) activator (Ki = 11.9 nM) wuth neuroprotective effects.
V33226	VTX-27	1321924-70-2	VTX-27 (VTX27) is a novel, potent and selective protein kinase C θ (PKC θ) inhibitor with Ki values of 0.08 nM and 16 nM for PKC θ and PKC δ.
V67541	ζ-Stat (NSC37044)	3316-02-7	ζ-Stat (NSC37044) is a specific and atypical inhibitor of PKC-ζ with IC50 of 5 μM.
V67540	ζ-Stat trisodium (NSC37044 trisodium)	31894-34-5	ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical inhibitor of PKC-ζ with IC50 of 5 μM.
V7780	R59022	93076-89-2	R59022 (R-59022; DKGI-I) is a novel and potent DGKalpha inhibitor and serotonin receptor antagonist.
V40351	N-Desmethyltamoxifen HCl	15917-65-4	N-Desmethyltamoxifen HCl is the major metabolite of Tamoxifen in the human body.
V25817	Phorbol 12,13-dibutyrate	37558-16-0	Phorbol 12,13-dibutyrate (PDBu; Phorbol dibutyrate) is a phorbol ester acting as a PKC activator and a potent skin tumor promoter.
V12078	Ingenol	30220-46-3	Ingenol is a PKC activator with Ki of 30 μM and anti-tumor activity.
V16477	Verbascoside (Acteoside; Kusaginin; TJC160)	61276-17-3	Verbascoside(Acteoside; Kusaginin; TJC-160), a natural productisolated from Lantana camara,is novel and potent inhibitor of the Oligomerization of Pneumolysin.