Ribosomal S6 Kinase (RSK) is a family of serine/threonine protein kinases involved in the regulation of cell viability.In response to mitogens, RSK is phosphorylated by the activation of one or more protein kinase cascades. The 70 kDa and 90 kDa S6 kinase families, which can be distinguished by size, are the two distinct mitogen-activated S6 kinase families that phosphorylate S6 in vivo. The activation of both S6 kinases occurs through serine/threonine phosphorylation.
The Ras/Raf/MEK/ERK signaling pathway's downstream effectors are members of the highly conserved Ser/Thr kinase family known as p90 ribosomal s6 kinase (1-4). They control a variety of cellular functions, including cell growth, motility, survival, and proliferation. AGC family member and key player in the mTOR signaling cascade is the p70 ribosomal protein S6 kinase.It is a multifunctional Ser/Thr kinase. Numerous cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth, and apoptosis are closely correlated with the p70 ribosomal protein S6 kinase.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0238 | BI-D1870 | 501437-28-1 | BI-D1870 is a specific, cell permeable and ATP-competitive inhibitor of RSK1/2/3/4 (p90 ribosomal S6 kinase) with the potential to treatautoimmune encephalomyelitis (EAE). |
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V0243 | H 89 2HCl | 130964-39-5 | H 89 2HCl is a highly selective inhibitor of protein kinase a (PKA). |
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V0242 | LJI308 | 1627709-94-7 | LJI308 is a novel, potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with potential antitumor activity. |
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V0240 | LY2584702 | 1082949-67-4 | LY2584702 is a novel, selective, orally bioavailable, and ATP-competitive inhibitor of p70S6K (ribosomal p70 S6 kinase) with potential antitumor activity. |
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V0241 | LY2584702 Tosylate (LYS-6K2) | 1082949-68-5 | LY2584702 Tosylate (also known as LYS6K2), the tosylate salt ofLY2584702,isa selective, orally bioavailable, and ATP-competitive p70S6K (ribosomal p70 S6 kinase) inhibitor with potential antitumor activity. |
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V0239 | PF-4708671 | 1255517-76-0 | PF-4708671 is a novel, potent, highly specific and cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform)/RSK1 with potential antitumor activity. |
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