Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1421 | (S)-10-Hydroxycamptothecin | 19685-09-7 | 10-Hydroxycamptothecin (also abbreviated as 10HCPT; 10OHCPT; HCPT; 10 HCPT), the 10-hydroxylated form of camptothecin, is a natural product and topoisomerase I inhibitor with potential anticancer activity. |
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V41233 | Aclarubicin (Aclacinomycin A) | 57576-44-0 | Aclarubicin (Aclacinon; Aclacin; Aclaplastin; Aclacinomycine; Jaclacin. ACM; Aclacinomycin A) is a natually occuring oligosaccharide and anthracycline anticancer antibiotic isolated from the bacterium Streptomyces galilaeus. |
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V11052 | Aminocamptothecin | 91421-43-1 | Aminocamptothecin (9-amino Camptothecin, 9-AC, 9-amino CPT), an analog of camptothecin (CPT) with higher water solubility, is a potent inhibitor of topoisomerase I with anti-tumor activity. |
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V1417 | Amonafide (AS1413) | 69408-81-7 | Amonafide (formerly NSC308847, AS1413; AS-1413;NSC-308847; Amonafide; Nafidimide; Benzisoquinolinedione; Quinamed; Xanafide),an imide derivative of naphthalic acid, is an inhibitor of topoisomerase II(Topo II) and also a DNA intercalator being investigated for the treatment of cancer. |
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V7168 | AQ4 | 70476-63-0 | AQ4 is a topoisomerase II inhibitor and DNA intercalator, and is a stable cytotoxic molecule in many human tumor cell lines. |
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V31201 | Banoxantrone dihydrochloride (AQ4N) | 252979-56-9 | Banoxantrone 2HCl (AQ4N), the dihydrochloride salt of Banoxantrone, is a hypoxia-activated and bioreductive prodrug that can be reduced under hypoxia (e.g. in hypoxic cells) to a stable, compound AQ4, which is a potent topoisomerase II inhibitor with antitumor activity. |
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V6360 | Belotecan Hydrochloride (CKD602) | 213819-48-8 | Belotecan HCl (CKD-602), thehydrochloride of CKD602 which isa Topoisomerase I inhibitor, is a semi-synthetic camptothecin analogue with potential antitumor activity. |
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V1980 | Berberine HCl | 633-65-8 | Berberine HCl (Natural Yellow 18 chloride), an isoqinoline alkaloid extracted from the Chinese herbal medicine Huanglian, is a quaternary ammonium salt from the group of isoquinoline alkaloids with varoius biological activities. |
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V1398 | Beta-Lapachone (ARQ-501) | 4707-32-8 | Beta-Lapachone (also known as ARQ-501; NSC 26326;ARQ501;NSC-26326) is a novel, naturally occurring, potent and selective DNA topoisomerase I inhibitor with potential antineoplastic activity. |
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V1401 | Betulinic acid (ALS357; Lupatic acid) | 472-15-1 | Betulinic acid (also known as ALS-357; LS-357; Mairin; Lupatic acid; Betulic acid)is a naturally occuring pentacyclic triterpenoid extracted from Syzigium claviflorum that displays anti-HIV and antitumor activity. |
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V29332 | Bisantrene | 78186-34-2 | Bisantrene (CL 216942; NSC 337766) is potent inhibitor of topoisomerase II and DNA intercalators. |
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V1391 | Camptothecin (Campathecin) | 7689-03-4 | Camptothecin (also known as Campathecin; CPT; NSC-100880), a naturally occurring quinoline alkaloid, is a potent and specific inhibitor of DNA enzyme topoisomerase I (Topo I) with potent antitumor activity. |
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V75881 | Camptothecin-20(S)-O-propionate hydrate (Camptothecin-20-O-propionate hydrate) | 1147090-70-7 | Camptothecin-20(S)-O-propionate (Camptothecin-20-O-propionate) hydrate is an analog of camptothecin (CPT) and a potent anti-tumor compound. |
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V1402 | Ciprofloxacin (Bay-09867) | 85721-33-1 | Ciprofloxacin (formerly known as Bay-09867;Bay09867;Baflox; Cetraxal; Ciprolin; Fimoflox; Proflaxin; Spitacin) is a broad-spectrum, fluoroquinolone class of antibiotic/antimicrobial which shows an MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml against various bacteria including Enterobacteriaceae, Haemophilus influenzae, Pseudomonas aeruginosa,Neisseria gonorrhoeae, Staphylococcus aureus,streptococci, and Bacteroidesfragilis strains. |
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V1415 | Clinafloxacin (AM-1091; CI-960) | 105956-97-6 | Clinafloxacin (formerly also known as CI-960; PD-127391; AM-1091; CI 960; PD127391; AM1091)is a broad-spectrum and investigational antibiotic of the fluoroquinolone class with promising antibiotic activity against gram-positive, gram-negative, and anaerobic pathogens. |
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V18484 | Clinafloxacin hydrochloride (PD127391) | 105956-99-8 | Clinafloxacin HCl (also known as CI-960, PD127391, AM-1091), thehydrochloridesalt of Clinafloxacin, is an investigational, broad-spectrumfluoroquinolone class of antibiotic that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. |
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V4896 | Daunorubicin | 20830-81-3 | Daunorubicin (also know as Daunomycin; RP 13057; Rubidomycin), an anthracycline analogue and a topoisomerase II inhibitor is mainly used as an antibiotic. |
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V1400 | Daunorubicin HCl (Daunomycin) | 23541-50-6 | Daunorubicin HCl (Daunomycin; RP-13057; Rubidomycin; Ondena; Rubilem; DNM; DNR; DRB; FI6339; RP13057), the hydrochloride salt of daunorubicin, is an anthracycline analog and a topoisomerase II inhibitor which is approved for use as an antibiotic and chemotherapeutic drug. |
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V2005 | Dexrazoxane xHCl (ICRF-187) | 149003-01-0 | Dexrazoxane xHCl (formerly also known as ICRF-187, ADR-529) acts as an intracellular iron chelator, which decreases the formation of superoxide radicals, and is mainly used as a cardioprotective agent. |
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V2644 | Doxorubicin | 23214-92-8 | Doxorubicin (Adriamycin; NSC-123127; FI-106; Adriblastine; Adrimedac) is a naturally occuring anthracycline antibiotic isolated from the bacterium Streptomyces peucetius var. |
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