Myosins are mechanoenzymes that interact with actin filaments and hydrolyse ATP to generate movement and force.This enables myosins to generate tension on actin filaments, which in turn allows them to walk along these filaments and propel the sliding of actin filaments. Myosins are able to control the cytoskeleton's dynamics and structure, which has an impact on how cells are transported and localized. According to their respective motor domains, the various myosins are divided into classes. Humans have 40 myosin genes, which are divided into 13 classes (I, II, III, V, VI, VII, IX, X, XV, XVI, XVIII, XIX, and XXXV) and represent the 35 known classes of myosin.
Muscle contraction, intracellular trafficking, cell division, motility, actin cytoskeletal organization, and cell signaling are just a few of the critical processes that myosins participate in. Deafness, hypertrophic cardiomyopathy, Usher syndrome, Griscelli syndrome, and cancer have all been linked to myosin dysfunction.
In order to perform its role in cytoskeleton contraction and tight junction regulation, the myosin light chain needs to be activated by the enzyme myosin light chain kinase (MLCK). In the majority of cells, MLCK functions as a signal transducer for MLC phosphorylation in response to Ca2+ binding to calmodulin associated with MLCK. Muscle contraction, cell migration, and endo/exocytic processes all benefit from MLCK-mediated MLC phosphorylation and actomyosin contractility, which is also known for playing a crucial part in signaling endothelial cell-cell adhesion and barrier function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V112138 | (R)-(+)-Blebbistatin O-Benzoate | 1217635-67-0 | (R)-(+)-Blebbistatin O-benzoate is a selective nonmyosin II inhibitor and a derivative of Blebbistatin. |
|
V88828 | (R)-MPH-220 | (R)-MPH-220 is the R-form of MPH-220. | |
|
V102814 | (S)-3'-Aminoblebbistatin | 2097141-18-7 | (S)-3'-Aminobrebistatin is a derivative of brebistatin. |
|
V102919 | (S)-3'-Hydroxy blebbistatin | 2097136-42-8 | (S)-3'-Hydroxybribstatin is a myosin II inhibitor that is more water soluble than bribstatin. |
|
V75828 | 16-38-Thymosin β4 (cattle) | 113318-05-1 | 16-38-Thymosin β4 (cattle) is a high-affinity Ca2+-independent MLCK activator. |
|
V77332 | 16-38-Thymosin β4 (cattle) (TFA) | 16-38-Thymosin β4 (cattle) TFA is a high-affinity Ca2+-independent MLCK activator. | |
|
V115416 | 1α-Hydroxyvitamin D5 | 187935-17-7 | 1α-hydroxyvitamin D5 (CARD-024) is a vitamin D analog with very low hypercalcemic effects. |
|
V104973 | Adhibin | Adhibin is an allosteric inhibitor of RhoGAP class IX myosin and inhibits Myo9 ATPase in mammals and invertebrates with IC50 of 2.5 µM and 2.6 µM, respectively. | |
|
V56060 | ATM-3507 trihydrochloride | 2438679-30-0 | ATM-3507 tri HCl is a potent inhibitor of tropomyosin, with IC50 of approximately 3.83-6.84 μM in human melanoma cell lines. |
|
V34749 | Blebbistatin (racemate) | 674289-55-5 | Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor that promotes directional migration of corneal endothelial cells and accelerates wound healing with better preservation of cell junction integrity and barrier function. |
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V17176 | BTS | 1576-37-0 | BTS is a novel and potent inhibitor of ATPase activity of skeletal muscle myosin II subfragment 1 (S1),specifically theCa2+-stimulated myosin S1 ATPase (IC50 = 5 μM). |
|
V116248 | Chrysosplenol C | 23370-16-3 | Hypericin C is a flavonoid compound. |
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V110372 | CK-571 | 1119536-89-8 | CK-571 is a potent and selective smooth muscle myosin-2 (SMM-2) inhibitor with an IC50 value of 86 nM. |
|
V51925 | JB002 | 30408-07-2 | JB002 is a myosin II inhibitor (antagonist) with IC50 ≤10 μM. |
|
V76866 | JB061 | JB061 is a non-muscle myosin inhibitor (antagonist) with IC50s of 4.4 μM (cardiac myosin), 9.1 μM (skeletal muscle myosin), and >100 μM (smooth muscle myosin II). | |
|
V51924 | JB062 | 2417988-00-0 | JB062 is a nonmuscle myosin inhibitor (antagonist) with IC50s of 1.6, 5.4 and >100 μM for skeletal muscle myosin, cardiac myosin and smooth muscle myosin II, respectively. |
|
V33894 | ML-7 hydrochloride hydrate | 110448-33-4 | ML-7 (ML7)hydrochloride hydrateis a naphthalene sulphonamide-based MLCK/Myosin light chain kinase inhibitor with anticancer activity. |
|
V41175 | MPH-220 | 2649776-79-2 | MPH-220 is a selective, orally bioactive skeletal muscle myosin-2 inhibitor. |
|
V114521 | MT-125 free base | 2404652-80-6 | MT-125 free base is a highly specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki, NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM). |
|
V56061 | MT-134 | 2968308-52-1 | MT-134 is a SkMII-specific inhibitor (antagonist) with good exposure in muscle. |
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