Myosin

Myosin

Myosins are mechanoenzymes that interact with actin filaments and hydrolyse ATP to generate movement and force.This enables myosins to generate tension on actin filaments, which in turn allows them to walk along these filaments and propel the sliding of actin filaments. Myosins are able to control the cytoskeleton's dynamics and structure, which has an impact on how cells are transported and localized. According to their respective motor domains, the various myosins are divided into classes. Humans have 40 myosin genes, which are divided into 13 classes (I, II, III, V, VI, VII, IX, X, XV, XVI, XVIII, XIX, and XXXV) and represent the 35 known classes of myosin.

Muscle contraction, intracellular trafficking, cell division, motility, actin cytoskeletal organization, and cell signaling are just a few of the critical processes that myosins participate in. Deafness, hypertrophic cardiomyopathy, Usher syndrome, Griscelli syndrome, and cancer have all been linked to myosin dysfunction.

In order to perform its role in cytoskeleton contraction and tight junction regulation, the myosin light chain needs to be activated by the enzyme myosin light chain kinase (MLCK). In the majority of cells, MLCK functions as a signal transducer for MLC phosphorylation in response to Ca2+ binding to calmodulin associated with MLCK. Muscle contraction, cell migration, and endo/exocytic processes all benefit from MLCK-mediated MLC phosphorylation and actomyosin contractility, which is also known for playing a crucial part in signaling endothelial cell-cell adhesion and barrier function.

Myosin related products

Structure Cat No. Product Name CAS No. Product Description
V75828 16-38-Thymosin β4 (cattle) 113318-05-1
V77332 16-38-Thymosin β4 (cattle) (TFA)
V56060 ATM-3507 trihydrochloride 2438679-30-0
V34749 Blebbistatin 674289-55-5
V17176 BTS 1576-37-0 BTS is a novel and potent inhibitor of ATPase activity of skeletal muscle myosin II subfragment 1 (S1),specifically theCa2+-stimulated myosin S1 ATPase (IC50 = 5 μM).
V51925 JB002 30408-07-2
V76866 JB061
V51924 JB062 2417988-00-0
V33894 ML-7 hydrochloride hydrate 110448-33-4 ML-7 (ML7)hydrochloride hydrateis a naphthalene sulphonamide-based MLCK/Myosin light chain kinase inhibitor with anticancer activity.
V41175 MPH-220 2649776-79-2
V56061 MT-134 2968308-52-1
V75829 Myosin Light Chain Kinase Substrate (smooth muscle) 119386-41-3
V35021 Myosin V-IN-1 1259177-59-7
V0063 Omecamtiv mecarbil (CK1827452) 873697-71-3 Omecamtiv mecarbil (also known as CK-1827452) is a specific/selective cardiac myosin activator and a clinical drug for left ventricular systolic heart failure.
V79889 Omecamtiv mecarbil-d8 (CK-1827452-d8)
V56062 Para-aminoblebbistatin 2097734-03-5
V52980 Sevasemten 2417395-15-2
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