Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine.The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0711 | AEBSF HCl | 30827-99-7 | AEBSF HCl (known also as AEBSF Hydrochloride) is a novel, broad spectrum, covalently/irreversible inhibitor of serine protease including trypsin, chymotrypsin, plasmin and thrombin. |
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V2631 | UK-371804 HCl | 256476-36-5 | UK-371804 is a potent and selective inhibitor of urokinase-type plasmogen activator (uPA) with excellent potency (Ki=10 nM in an enzyme assay) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
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V39637 | ZK824190 | 2254001-81-3 | ZK824190 is an orally bioavailable, selective urokinase plasminogen activator (uPA) inhibitor for use in multiple sclerosis research. |
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V4220 | Fulacimstat | 1488354-15-9 | Fulacimstat (also known as BAY1142524) is a novel, potent and orally bioavailable chymase inhibitor with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively. |
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V0710 | Aprotinin | 9087-70-1 | Aprotinin is a novel and potent small protein serine protease / bovine pancreatic trypsin inhibitor (BPTI) with antifibrinolytic activity. |
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V2211 | FOY-251 mesylate | 71079-09-9 | FOY 251 mesylate is a Camostat metabolite with anti-proteolytic activity, and acts as a proteinase inhibitor. |
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V0709 | Gabexate Mesylate (Megacert; Arodate) | 56974-61-9 | Gabexate Mesylate (Megacert; Arodate) is a novel, potent and synthetic inhibitor of serine protease with anti-coagulant activity. |
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V0707 | Nafamostat Mesylate (FUT175) | 82956-11-4 | Nafamostat mesylate (formerly also known as FUT-175) is a novel and synthetic serine protease inhibitor, which is used as ashort-acting anticoagulant during hemodialysis. |
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V0713 | Alvelestat (AZD-9668; MPH-966) | 848141-11-7 | Alvelestat (formerly also known as MPH966; AZD9668) is a novel, potent, orally bioavailable, and highly selective inhibitor of neutrophil elastase (NE) with potential anti-inflammatory activity. |
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