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HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Structure Cat No. Product Name CAS No. Product Description
4-溴苯甲酸-2-丁基酰肼 V4087 UF010 537672-41-6 UF010 (UF-010; UF 010) is a novel, potent and selective class I HDAC inhibitor with potential anticancer activities.
ACY-775 V3772 ACY-775 1375466-18-4 ACY-775, anovel pyrimidine hydroxyl amide small molecule, is a brain bioavailable, highly potent and isoform-selective inhibitor of HDAC6 with IC50of 7.5 nM.
AES-350 V2346 AES-350 847249-57-4 AES-350 is a potent orally bioactive HDAC6 inhibitor (antagonist) with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively.
ALK/HDAC-IN-1 V89054 ALK/HDAC-IN-1 ALK/HDAC-IN-1 is a dual inhibitor of ALK and HDAC6 with IC50 of 16 nM and 1.03 μM, respectively.
AW01178 V88674 AW01178 651293-70-8 AW01178 is a class I HDAC inhibitor.
BATCP V85459 BATCP 787549-23-9
BRD6688 V9315 BRD6688 1404562-17-9 BRD6688 (BRD-6688; BRD 6688) is a novel and potent HDAC1/2/3 inhibitor with IC50s of 21 nM, 100 nM, and 11.48 μM, respectively.
CM-1758 V84303 CM-1758 2256079-39-5
Crebinostat V18790 Crebinostat 1092061-61-4 Crebinostat is a novel and potent HDAC (histone deacetylase) inhibitor with anticancer and neuroprotective effects.
CYP17A1/HDAC6-IN-1 V87366 CYP17A1/HDAC6-IN-1 CYP17A1/HDAC6-IN-1 (compound 12) is a potent inhibitor of CYP17A1 and HDAC6 with IC50 of 0.284μM and 0.6015 μM respectively.
DL-Sulforaphane N-acetyl-L-cysteine V88667 DL-Sulforaphane N-acetyl-L-cysteine 334829-66-2 DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and a metabolite of sulforaphane with a longer half-life and better blood-brain barrier permeability.
DLC-50 V88739 DLC-50 2928537-98-6 DLC-50 is a dual inhibitor of PARP-1 and HDAC-1 with IC50 of 1.2 nM and 31 nM, respectively.
FT895 V31524 FT895 2225728-57-2 FT895 is a potent and specific HDAC11 inhibitor (antagonist) with IC50 of 3 nM.
Givinostat盐酸盐 V3844 Givinostat HCl 199657-29-9 Givinostat (ITF-2357 hydrochloride)is a potent andorally bioactive HDAC inhibitor with potential anti-inflammatory, anti-angiogenic, and anticancer activities.
GSK-3β/HDAC-IN-1 V87896 GSK-3β/HDAC-IN-1 GSK-3β/HDAC-IN-1 (Compd 4) is a first-in-class non-ATP-competitive glycogen synthase kinase 3β/histone deacetylase (GSK-3β/HDACs) inhibitor that penetrates the blood-brain barrier, with IC50 of 0.142, 0.03, and 0.045 μM for GSK-3β, HDAC2, and HDAC6, respectively
HDAC-IN-53 V51325 HDAC-IN-53 2921948-27-6 HDAC-IN-53 is a novel HDAC1-3 inhibitor that has IC50 values of 47 nM, 125 nM, and 450 nM, in that order.
HDAC-IN-67 V84662 HDAC-IN-67 2821923-75-3
HDAC-IN-68 V85250 HDAC-IN-68
HDAC-IN-69 V85180 HDAC-IN-69
HDAC-IN-70 V88526 HDAC-IN-70 HDAC-IN-70 (compound 4c) is an HDAC6 inhibitor with IC50 values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively.
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