HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Structure Cat No. Product Name CAS No. Product Description
V3772 ACY-775 1375466-18-4 ACY-775, anovel pyrimidine hydroxyl amide small molecule, is a brain bioavailable, highly potent and isoform-selective inhibitor of HDAC6 with IC50of 7.5 nM.
V2346 AES-350 847249-57-4 AES-350 is a potent orally bioactive HDAC6 inhibitor (antagonist) with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively.
V11458 Apicidin 183506-66-3 Apicidin (OSI-2040; OSI2040) is a novel and potent histone deacetylases (HDAC) inhibitor and apoptosis inducer with potential anticancer activity.
V85459 BATCP 787549-23-9
V9315 BRD6688 1404562-17-9 BRD6688 (BRD-6688; BRD 6688) is a novel and potent HDAC1/2/3 inhibitor with IC50s of 21 nM, 100 nM, and 11.48 μM, respectively.
V3843 Chidamide (Tucidinostat, HBI8000, CS 055) 1616493-44-7 Chidamide (CS-055, Tucidinostat, HBI-8000; trade name: Epidaza), is a potent and orally bioavailable benzamide-type histone deacetylase (HDAC) inhibitor with IC50s of 95, 160, 67 and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10, respectively.
V3681 Citarinostat (ACY241) 1316215-12-9 Citarinostat (ACY-241; ACY241;HDAC-IN-2) is a novel, potent, orally bioavailable and selective inhibitor of HDAC6 (histone deacetylase) with anticancer activity.
V84303 CM-1758 2256079-39-5
V18790 Crebinostat 1092061-61-4 Crebinostat is a novel and potent HDAC (histone deacetylase) inhibitor with anticancer and neuroprotective effects.
V31524 FT895 2225728-57-2 FT895 is a potent and specific HDAC11 inhibitor (antagonist) with IC50 of 3 nM.
V3845 Givinostat 497833-27-9 Givinostat (formerlyknown asITF-2357; Gavinostat)is a potent and orally bioactive inhibitor of both class I and class II histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and anticancer activities.
V3844 Givinostat HCl 199657-29-9 Givinostat (ITF-2357 hydrochloride)is a potent andorally bioactive HDAC inhibitor with potential anti-inflammatory, anti-angiogenic, and anticancer activities.
V51325 HDAC-IN-53 2921948-27-6 HDAC-IN-53 is a novel HDAC1-3 inhibitor that has IC50 values of 47 nM, 125 nM, and 450 nM, in that order.
V84662 HDAC-IN-67 2821923-75-3
V85250 HDAC-IN-68
V85180 HDAC-IN-69
V84738 HDAC1-IN-6
V84576 HDAC3-IN-3 2170996-03-7
V85393 HDAC6-IN-28
V85597 HDAC6-IN-29
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