HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121930 | (R)-HDAC-IN-102 | 1177382-00-1 | (R)-HDAC-IN-102 is an HDAC2 inhibitor and an isomer of HDAC-IN-102. |
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V122028 | (Rac)-Nanatinostat | 914937-68-1 | (Rac)-Nanatinostat is a potent HDAC inhibitor with an IC50 of <330 nM. |
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V122172 | (S)-HDAC-IN-102 | 748159-43-5 | (S)-HDAC-IN-102 is an HDAC8 inhibitor and an isomer of HDAC-IN-102. |
|
V124890 | 2-Propylpent-4-ynoic acid | 24102-11-2 | 2-Propylpent-4-ynoic acid is a histone deacetylase (HDAC) inhibitor (IC50 for human HDAC is 0.5 mM). |
|
V126511 | 4-Phenylcinnamic acid | 13026-23-8 | 4-Phenylcinnamic acid is a weak HDAC2 inhibitor (IC50 > 5 μM). |
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V4087 | UF010 | 537672-41-6 | UF010 (UF-010; UF 010) is a novel, potent and selective class I HDAC inhibitor with potential anticancer activities. |
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V104653 | AAK1/HDACs-IN-1 | AAK1/HDACs-IN-1 (Compound 12) is a dual inhibitor of AAK1 and HDAC, inhibiting AAK1, HDAC1, and HDAC6 with IC50 of 15.9, 148.6, and 5.2 nM, respectively. | |
|
V128213 | Ac-QPKK(Ac)-AMC acetate | Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide coupled with a fluorophore and can be used as a fluorescent peptide substrate for detecting zinc-dependent HDAC and sirtuins deacylation activities (excitation wavelength = 360 nm; emission wavelength = 460 nm). | |
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V97450 | Acefylline piperazine | 18833-13-1 | Acetylphylline piperazine is a xanthine derivative and adenosine receptor antagonist. |
|
V3772 | ACY-775 | 1375466-18-4 | ACY-775, anovel pyrimidine hydroxyl amide small molecule, is a brain bioavailable, highly potent and isoform-selective inhibitor of HDAC6 with IC50of 7.5 nM. |
|
V2346 | AES-350 | 847249-57-4 | AES-350 is a potent orally bioactive HDAC6 inhibitor (antagonist) with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. |
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V89054 | ALK/HDAC-IN-1 | ALK/HDAC-IN-1 is a dual inhibitor of ALK and HDAC6 with IC50 of 16 nM and 1.03 μM, respectively. | |
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V110352 | AMC-3-030 | 2926656-07-5 | AMC-3-030 is a selective and potent dual inhibitor that targets HDAC6 and the chymotrypsin-like proteasome, with IC50 values of 884 nM and 4.17 nM, respectively. |
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V88674 | AW01178 | 651293-70-8 | AW01178 is a class I HDAC inhibitor. |
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V85459 | BATCP | 787549-23-9 | |
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V9315 | BRD6688 | 1404562-17-9 | BRD6688 (BRD-6688; BRD 6688) is a novel and potent HDAC1/2/3 inhibitor with IC50s of 21 nM, 100 nM, and 11.48 μM, respectively. |
|
V103228 | Butyrylhydroxamic acid | 4312-91-8 | Butyrylhydroxamic acid (N-hydroxybutyramide) is a potent histone deacetylase (HDAC) inhibitor. |
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V131306 | CDK9/HDAC1/HDAC3-IN-1 | 2197029-81-3 | CDK9/HDAC1/HDAC3-IN-1 is a bifunctional inhibitor of CDK9 and HDAC. |
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V103342 | CHDI-00484077 | 3025894-92-9 | CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor with IC50 of 0.01 μM (HDAC4), 0.02 μM (HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9). |
|
V131923 | CLK1/4-IN-2 | 2101206-26-0 | CLK1/4-IN-2 is a selective CLK1/4 inhibitor with an IC50 value of 7 nM for CLK1 and 2.3 nM for CLK4. |
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