Both the soluble and particulate fractions of cells contain guanylate cyclase (also known as guanylyl cyclase, or GC), which catalyzes the formation of cGMP from GTP. Guanylyl cyclases send out signals by making cGMP, the second messenger.
Particulate GC (pGC) and a soluble GC (sGC) activated by nitric oxide make up the GC family. (pGC-A to pGC-G) Seven pGC isoforms have so far been identified. Peptide ligands that bind to the extracellular domains of pGCs activate them. The core enzyme in the nitric oxide signal transduction pathway, sGC, is a receptor for endogenous and exogenous nitric oxide and is activated several times upon its binding. Vasodilation, smooth muscle relaxation, and platelet aggregation are just a few of the significant physiologic responses that are triggered by the second messenger cGMP, which is produced by sGC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1869 | BAY 41-2272 | 256376-24-6 | BAY 41-2272 is a novel and potent activator of nitric oxide-sensitive guanylyl cyclase (NO-sensitive GC) with EC50 values of 0.3 μmol/L and 3 μmol/L in the presence and absence of 100 nmol/L DEA-NO, respectively. |
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V5898 | BAY-41-8543 | 256498-66-5 | BAY-41-8543 is a novel and potent NO-independent guanylyl cyclase stimulator. |
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V74642 | BAY-747 (BAY 1165747) | 1609342-18-8 | BAY-747 (BAY 1165747) is an orally bioactive and brain-penetrating soluble guanylyl cyclase (sGC) stimulator. |
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V74643 | Cenderitide | 507289-11-4 | Cenderitide is a potent particulate ornityl cyclase receptor (pGC) agonist. |
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V74636 | CFM 1571 hydrochloride | 1215548-30-3 | CFM 1571 HCl is a stimulator of nitric oxide receptor soluble guanylyl cyclase (sGC) with EC50 and IC< sub>50 of 5.49 μM and 2.84 μM, respectively. |
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V4213 | Cinaciguat | 329773-35-5 | Cinaciguat (formerly also known as BAY582667 or BAY58-2667) is a novel and potent activator of soluble guanylate cyclase (sGC) used for acute decompensated heart failure. |
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V4214 | Cinaciguat HCl | 646995-35-9 | Cinaciguat HCl, the hydrochloride salt of Cinaciguat (formerly also known as BAY582667 or BAY58-2667), is a novel and potent activator of soluble guanylate cyclase (sGC) used for acute decompensated heart failure. |
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V10990 | Ebselen oxide | 104473-83-8 | Ebselen oxide, formed by the oxidation of ebselen, is a novel and potent inhibitor of Histone deacetylase (HDAC1/3/4/5/6/7/8/9). |
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V74640 | Guanylate cyclase-IN-1 | 1361569-23-4 | Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that may be utilized in cardiovascular disease study. |
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V74635 | Guanylin (mouse, rat) | 145257-03-0 | Guanylin (mouse, rat), a polypeptide consisting of 15 amino acid (AA)s. |
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V74637 | Indusatumab (5F9 Monoclonal antibody) | 1497400-26-6 | Indusatumab (5F9 monoclonal antibody (mAb)) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody (mAb). |
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V24128 | Lificiguat (YC 1) | 170632-47-0 | Lificiguat, formerly known as YC-1, is a potent inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). |
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V4760 | Linaclotide | 851199-59-2 | Linaclotide (trade name Linzess in the US and Mexico, and as Constella elsewhere) is a novel, potent, selective and orally administered, peptide agonist of guanylate cyclase Cdeveloped for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. |
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V24725 | LY83583 | 91300-60-6 | LY83583 (LY 83583; LY-83583) is a novel and potent inhibitor of multple target proteins such as Msp1 and guanylate cyclase, also acts as a cGMP modulator that inhibits cGMP production. |
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V25450 | Methylthioninium chloride hydrate | Methylthioninium chloride hydrate (C.I. Basic Blue 9 trihydrate) is an inhibitor of guanylyl cyclase (sGC) as well as monoamine oxidase A (MAO-A) and NO synthase (NOS). | |
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V77918 | MGV354 | MGV354 is a soluble guanylate cyclase (sGC) activator with EC50 of <0.5 nM and 5 nM in CHO and GTM-3E cells, respectively. | |
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V74641 | MM419447 | 1092457-78-7 | MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. |
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V74639 | Mosliciguat (BAY 1237592) | 2231749-54-3 | Mosliciguat is a guanylate cyclase activator. |
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V4206 | Nelociguat | 625115-52-8 | Nelociguat (also known as BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator (sGC stimulator). |
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V4101 | ODQ | 41443-28-1 | ODQ is a novel, potent and selective inhibitor of soluble guanylyl cyclase (sGC). |
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