Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0787 | S- (+)-Rolipram (ME-3167; SB95952; ZK-62711) | 85416-73-5 | S-(+)-Rolipram, theS-isomer of rolipram (ME3167;SB-95952; ZK62711), isa potent phosphodiesterase PDE4-inhibitor with potent anti-inflammatory and anti-depressant activity. |
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V51292 | Carbazeran citrate | 153473-94-0 | Carbazeran (citrate) is a potent phosphodiesterase inhibitor and aldehyde oxidase substrate. |
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V51451 | Deltasonamide 1 TFA | 2235358-73-1 | Deltasonamide 1 TFA is a PDE6δ-KRas dye. |
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V37637 | Enpp-1-IN-1 | 2289728-58-9 | Enpp-1-IN-1 is a potent and specific enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor. |
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V51610 | FCPR-03 | 1917347-65-9 | FCPR03 is a potent and specific phosphodiesterase 4 (PDE4) conjugate with IC50s of 60 nM, 31 nM and 47 nM for the PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively. |
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V51611 | FCPR-16 | PDE4 inhibitor | |
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V0783 | GSK256066 | 801312-28-7 | GSK256066 (GSK-256066; GSK 256066) is a novel, potent and selective inhibitor of PDE4B (phosphodiesterase 4B) with important biological activity (e. |
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V51700 | LASSBio-1632 | 3029936-02-2 | LASSBio-1632 is a lead compound with anti-asthmatic activity that selectively inhibits PDE4A and PDE4D isoenzymes, blocking airway hyperresponsiveness and TNF-α production in lung tissue. |
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V14147 | Lotamilast (RVT501; E6005) | 947620-48-6 | Lotamilast (formerly RVT-501; E-6005) is a novel, potent and selective inhibitor of phosphodiesterase 4 (PDE-4,IC50= 2.8 nM) with the potential to be used for the treatment of AD/atopic dermatitis. |
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V0792 | Mardepodect (PF-2545920; MP-10) | 898562-94-2 | Mardepodect (formerly known as PF-2545920, PF2545920, MP10; MP-10) is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with antipsychotic activity. |
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V2648 | Mardepodect HCl (PF-2545920 HCl) | 2070014-78-5 | Mardepodect HCl, the hydrochloric acid salt of PF-2545920 (Also known as Mardepodect,MP-10), is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with IC50 of 0.37 nM, andwith >1000-fold selectivity over the PDE. |
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V51037 | MK-8189 | 1424371-93-6 | MK-8189 is a potent and specific PDE10A with a Ki of 29 pM. |
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V3378 | PF-8380 | 1144035-53-9 | PF-8380 is a novel, potent andspecificautotaxin (ATX)inhibitor with anIC50of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. |
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V13927 | RO2959 HCl | 1219927-22-6 | RO2959 is a novel, potent and highly selective CRAC current inhibitor (IC50 of 402 nM), also a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. |
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V2623 | TAK-063 (Balipodect) | 1238697-26-1 | Balipodect (formerly also known as TAK-063) is a novel,highly potent, orally bioavailable and selective phosphodiesterase 10A (PDE10A) inhibitor with potential usefulness inthe treatment of schizophrenia. |
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V3099 | Ziritaxestat (GLPG-1690) | 1628260-79-6 | Ziritaxestat (formerly GLPG1690) is a potent and a first-in-class selective autotaxin (ATX)inhibitor (IC50 = 131 nM andKiof 15 nM) with the potential to be used in the treatment of idiopathic pulmonary disease (IPF). |
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V4577 | Udenafil | 268203-93-6 | Udenafil (formerly known as DA8159) isa novel and potent PDE5 inhibitor used in urology to treat erectile dysfunction. |
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V0793 | Dyphylline | 479-18-5 | Dyphylline (also named as Diprophylline; Corphyllin;Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects,is used in the treatment of respiratory disorders like cardiac dyspnea,asthma, and bronchitis. |
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V0780 | Tadalafil (IC 351; Cialis) | 171596-29-5 | Tadalafil (formerly known as IC351; IC-351;trade name Cialis) is a potent, orally bioavailable, reversible and competitive small-molecule inhibitor of PDE-5 (phosphodiesterase 5) with the potential to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension. |
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V0796 | Irsogladine | 57381-26-7 | Irsogladine (MN1695; MN 1695; Gaslon; MN-1695; Dicloguamine),a mucosal protective drug, is a novel and potent PDE4 inhibitor and muscarinic acetylcholine receptor binder with anti-ulceric activity. |
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