Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0785 | Aminophylline | 317-34-0 | Aminophylline (also known asPhyllocontin;Euphyllin; Truphylline),a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio,is a novel,potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM. |
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V0789 | Anagrelide HCl | 58579-51-4 | Anagrelide HCl (formerlyBL4162A;BL-4162A; BL-4162-A; trade names Agrylin/Xagrid, Shire and Thromboreductin), the hydrochloride salt ofAnagrelide, is an approved drug used for the treatment of essential thrombocytosis (thrombocythemia) and overproduction of blood platelets. |
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V0082 | Apremilast (CC10004) | 608141-41-9 | Apremilast (also known as CC-10004), a thalidomide analog, is a novel and orally bioavailable small molecule inhibitor of the phosphodiesterase 4 (PDE4) with potential anti-inflammatory activity. |
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V0797 | Avanafil | 330784-47-9 | Avanafil (also known as TA 1790; TA1790; TA-1790; trade name: Stendra; Spedra)is a highly potent and selective PDE5 inhibitor with potential vasodilating effects. |
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V51292 | Carbazeran citrate | 153473-94-0 | Carbazeran (citrate) is a potent phosphodiesterase inhibitor and aldehyde oxidase substrate. |
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V0779 | Cilomilast (SB207499; Ariflo) | 153259-65-5 | Cilomilast (also known asSB-207,499; SB207499; trade name Ariflo)is a novel, potent andorally bioactive phosphodiesterase 4/PDE4 inhibitorwith potential anti-inflammatory and immunomodulatory activity. |
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V0791 | Cilostazol (OPC-13013; OPC13013; OPC 13013) | 73963-72-1 | Cilostazol(formerly OPC-13013; Pletal; Cilostazolum; Pletaal;OPC13013; OPC 13013),a potentvasodilator that acts by relaxing the muscles,is a selective cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with beneficial effects on learning impairment. |
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V3148 | Crisaborole | 906673-24-3 | Crisaborole (formerly known as AN-2728; PF-06930164; AN2728; PF06930164;trade name:Eucrisa) is a potent and selectivePDE4 (phosphodiesterase 4) inhibitor with a broad-spectrum of anti-inflammatory activity. |
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V0784 | Deltarasin | 1440898-61-2 | Deltarasin (also known as Deltarasin hydrochloride) is a novel,high affinity and potent small molecule inhibitor of KRAS-PDEδ protein-protein interaction with potential antineoplastic activity. |
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V51451 | Deltasonamide 1 TFA | 2235358-73-1 | Deltasonamide 1 TFA is a PDE6δ-KRas dye. |
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V1999 | Diosgenin | 512-04-9 | Diosgenin is a plant steroidal sapogenin which induces apoptosis in colon cancer cell lines and induces apoptosis,cell cycle arrest and COX activity in osteosarcoma cells. |
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V0790 | Dipyridamole ( NSC-515776; RA-8; Persantine) | 58-32-2 | Dipyridamole (also known as NSC515776; RA8; Persantine) is a pyrimido-pyrimidine based phosphodiesterase (PDE) inhibitor with antiplatelet properties. |
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V0794 | Doxofylline | 69975-86-6 | Doxofylline (also known as Neothylline;Ansimar; ABC-1213; ALT-07; Lufyllin;DO-309; Diprophylline; Corphyllin; ABC-12-3),a xanthine derivative,is a novel and potent PDE (phosphodiesterase) inhibitor with the potential for treating asthma. |
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V0793 | Dyphylline | 479-18-5 | Dyphylline (also named as Diprophylline; Corphyllin;Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects,is used in the treatment of respiratory disorders like cardiac dyspnea,asthma, and bronchitis. |
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V37637 | Enpp-1-IN-1 | 2289728-58-9 | Enpp-1-IN-1 is a potent and specific enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor. |
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V51610 | FCPR-03 | 1917347-65-9 | FCPR03 is a potent and specific phosphodiesterase 4 (PDE4) conjugate with IC50s of 60 nM, 31 nM and 47 nM for the PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively. |
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V51611 | FCPR-16 | PDE4 inhibitor | |
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V0798 | Fenspiride HCl | 5053-08-7 | Fenspiride (NAT-333; JP-428;NDR-5998A; Decaspiride; Espiran; trade names Eurespal, Pneumorel), anoxazolidinone spiro compound acting as aα adrenergic and H1 histamine receptor antagonist,is a bronchodilator with potentanti-inflammatory properties. |
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V0783 | GSK256066 | 801312-28-7 | GSK256066 (GSK-256066; GSK 256066) is a novel, potent and selective inhibitor of PDE4B (phosphodiesterase 4B) with important biological activity (e. |
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V3145 | Ibudilast (KC404, AV411， MN166) | 50847-11-5 | Ibudilast (formerly known as KC-404, AV-411 or MN-166) is a potent and nonspecific/nonselective inhibitor of the phosphodiesterase (PDE). |
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