ERR

ERR

Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.

ERR related products

Structure Cat No. Product Name CAS No. Product Description
V67685 (Rac)-Zearalanone-d6 1795020-90-4
V67646 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) 549-02-0
V67691 3'-Hydroxymirificin 168035-02-7
V67711 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone 151752-07-7
V67658 4-Nonylphenol-d5 (4-n-Nonylphenol-2,3,5,6-d4,OD) 358730-95-7
V67720 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 25848-69-5
V4677 Acolbifene (EM 652; SCH 57068) 182167-02-8 Acolbifene (also known as EM-652 and SCH-57068) is a novel, potent and selective estrogen receptor modulator/antatonist (SERM) with a IC50 value of 22±3 nM.
V67687 Arzoxifene (LY353381; SERM III) 182133-25-1
V2047 Avobenzone (BF2AVB) 70356-09-1 AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM. AZD9496 showed pmol/L equipotent binding to both ERα and ERβ isoforms.
V2554 AZD9496 1639042-08-2 AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM.
V2643 AZD9496 maleate 1639042-28-6 AZD9496 (AZD-9496) maleate is a novel, potent, orally bioavailable, andselective estrogen receptor (ERα) downregulator and antagonist with anticancer activity.
V67699 Bazedoxifene-d4 acetate (TSE-424-d4 acetate) 1795027-71-2
V67670 Bexirestrant 2505067-70-7
V2995 Brilanestrant 1365888-06-7 Brilanestrant (formerly known as GDC-0810, ARN-810 and/or RG6046) isa novel, potent and orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity inmodels of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer.
V18266 Chrysin 480-40-0 Chrysin is a novel and potent flavone.
V67684 CIDD-0149897 2862784-20-9
V67673 Clomiphene-d5 citrate (enclomiphene citrate d5 (citrate)) 1217200-17-3
V67668 Corifollitropin alfa (Org 36286; MK-8962) 195962-23-3
V67690 Dehydrodiconiferyl alcohol 4263-87-0
V19820 Dienestrol 84-17-3 Dienestrol is a synthetic, non-steroidal estrogen acting as an estrogen receptor agonist for the treatment of menopausal and postmenopausal symptoms.
Contact Us