Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84022 | (E)-Octinoxate ((E)-Octyl methoxycinnamate) | 83834-59-7 | |
|
V67685 | (Rac)-Zearalanone-d6 | 1795020-90-4 | (Rac)-Zearalanone-d6 is the racemic deuterated form of Zearalenone. |
|
V105942 | 10-Chloroestra-1,4-diene-3,17-dione | 91413-55-7 | 10-Chloroestradiol-1,4-diene-3,17-dione (10-CIEsra) is a derivative of the estrogen receptor. |
|
V67646 | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) | 549-02-0 | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeted estrogen precursor. |
|
V103155 | 2-Bromoestradiol | 15833-07-5 | 2-Bromoestradiol is an estrogen 2-hydroxylase inhibitor. |
|
V106522 | 2-Ethylhexyl diphenyl phosphate | 1241-94-7 | 2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and a PPARG agonist (EC20: 2.04 µM). |
|
V67691 | 3'-Hydroxymirificin | 168035-02-7 | 3'-Hydroxymirificin (compound 3) is a naturally occurring compound obtained from the roots of Pueraria lobata. |
|
V105528 | 3-Formylsalicylic acid | 610-04-8 | 3-Formylsalicylic acid is a noncompetitive estrone sulfatase inhibitor with IC50 of 0.15 mM and Ki of 0.12 mM. |
|
V11151 | Estradiol dipropionate | 113-38-2 | Estradiol dipropionate is an estrogen-progesterone combination that works as an estrogen and progesterone agonist. |
|
V67711 | 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone | 151752-07-7 | 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone is an estrogen agonist with binding affinity to bovine uterine estrogen receptors with IC50 of 15 μM [1]. |
|
V107243 | 4,4'-(Cyclohexylidenemethylene)diphenol | 5189-40-2 | 4,4'-(Cyclohexylmethoxy)diphenol (Compound 2) is a symmetrical cyclic nonsteroidal estrogen. |
|
V67658 | 4-Nonylphenol-d5 (4-n-Nonylphenol-2,3,5,6-d4,OD) | 358730-95-7 | 4-Nonylphenol-d5 is the deuterated form of 4-Nonylphenol. |
|
V107193 | 6:2 Cl-PFAES | 73606-19-6 | 6:2 Cl-PFAES is reproductively toxic. |
|
V67720 | 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) | 25848-69-5 | 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) binds to ERβ and has anti~inflammatory and neuro-protective (neuro-protection) properties. |
|
V93836 | ADX61623 | 1067189-44-9 | ADX61623 is a potent negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). |
|
V101569 | Antiproliferative agent-51 | Antiproliferative agent-51 (Compound 18h) inhibits estrogen receptor α (ERα)-mediated transcription with IC50 of 1.6 nM. | |
|
V67687 | Arzoxifene (LY353381; SERM III) | 182133-25-1 | Arzoxifene (LY353381) is an orally bioactive selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. |
|
V2554 | AZD9496 | 1639042-08-2 | AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM. |
|
V2643 | AZD9496 maleate | 1639042-28-6 | AZD9496 (AZD-9496) maleate is a novel, potent, orally bioavailable, andselective estrogen receptor (ERα) downregulator and antagonist with anticancer activity. |
|
V67699 | Bazedoxifene-d4 acetate (TSE-424-d4 acetate) | 1795027-71-2 | Bazedoxifene-d4 (acetate) is the deuterated form of Bazedoxifene. |
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