Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84022 | (E)-Octinoxate ((E)-Octyl methoxycinnamate) | 83834-59-7 | |
|
V67685 | (Rac)-Zearalanone-d6 | 1795020-90-4 | (Rac)-Zearalanone-d6 is the racemic deuterated form of Zearalenone. |
|
V67646 | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) | 549-02-0 | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeted estrogen precursor. |
|
V67691 | 3'-Hydroxymirificin | 168035-02-7 | 3'-Hydroxymirificin (compound 3) is a naturally occurring compound obtained from the roots of Pueraria lobata. |
|
V67711 | 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone | 151752-07-7 | 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone is an estrogen agonist with binding affinity to bovine uterine estrogen receptors with IC50 of 15 μM [1]. |
|
V67658 | 4-Nonylphenol-d5 (4-n-Nonylphenol-2,3,5,6-d4,OD) | 358730-95-7 | 4-Nonylphenol-d5 is the deuterated form of 4-Nonylphenol. |
|
V67720 | 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) | 25848-69-5 | 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) binds to ERβ and has anti~inflammatory and neuro-protective (neuro-protection) properties. |
|
V4677 | Acolbifene (EM 652; SCH 57068) | 182167-02-8 | Acolbifene (also known as EM-652 and SCH-57068) is a novel, potent and selective estrogen receptor modulator/antatonist (SERM) with a IC50 value of 22±3 nM. |
|
V67687 | Arzoxifene (LY353381; SERM III) | 182133-25-1 | Arzoxifene (LY353381) is an orally bioactive selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. |
|
V2047 | Avobenzone (BF2AVB) | 70356-09-1 | AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM. AZD9496 showed pmol/L equipotent binding to both ERα and ERβ isoforms. |
|
V2554 | AZD9496 | 1639042-08-2 | AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM. |
|
V2643 | AZD9496 maleate | 1639042-28-6 | AZD9496 (AZD-9496) maleate is a novel, potent, orally bioavailable, andselective estrogen receptor (ERα) downregulator and antagonist with anticancer activity. |
|
V67699 | Bazedoxifene-d4 acetate (TSE-424-d4 acetate) | 1795027-71-2 | Bazedoxifene-d4 (acetate) is the deuterated form of Bazedoxifene. |
|
V84131 | BE-26263 | 147716-81-2 | |
|
V67670 | Bexirestrant | 2505067-70-7 | Bexirestrant is an orally bioactive ER-α degrader. |
|
V2995 | Brilanestrant | 1365888-06-7 | Brilanestrant (formerly known as GDC-0810, ARN-810 and/or RG6046) isa novel, potent and orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity inmodels of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer. |
|
V18266 | Chrysin | 480-40-0 | Chrysin is an estrogen blocker. |
|
V67684 | CIDD-0149897 | 2862784-20-9 | CIDD-0149897 is a potent, selective and BBB (blood-brain barrier) permeable/penetrable ERβ agonist. |
|
V84754 | CITFA | 2379989-52-1 | |
|
V67673 | Clomiphene-d5 citrate (enclomiphene citrate d5 (citrate)) | 1217200-17-3 | Clomiphene-d5 (citrate) is the deuterated form of Enclomiphene citrate. |
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