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Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.

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Structure Cat No. Product Name CAS No. Product Description
(E)-Octinoxate ((E)-Octyl methoxycinnamate) V84022 (E)-Octinoxate ((E)-Octyl methoxycinnamate) 83834-59-7
(Rac)-Zearalanone-d6 V67685 (Rac)-Zearalanone-d6 1795020-90-4 (Rac)-Zearalanone-d6 is the racemic deuterated form of Zearalenone.
10-Chloroestra-1,4-diene-3,17-dione V105942 10-Chloroestra-1,4-diene-3,17-dione 91413-55-7 10-Chloroestradiol-1,4-diene-3,17-dione (10-CIEsra) is a derivative of the estrogen receptor.
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) V67646 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) 549-02-0 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeted estrogen precursor.
2-Bromoestradiol V103155 2-Bromoestradiol 15833-07-5 2-Bromoestradiol is an estrogen 2-hydroxylase inhibitor.
2-Ethylhexyl diphenyl phosphate V106522 2-Ethylhexyl diphenyl phosphate 1241-94-7 2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and a PPARG agonist (EC20: 2.04 µM).
3'-Hydroxymirificin V67691 3'-Hydroxymirificin 168035-02-7 3'-Hydroxymirificin (compound 3) is a naturally occurring compound obtained from the roots of Pueraria lobata.
3-Formylsalicylic acid V105528 3-Formylsalicylic acid 610-04-8 3-Formylsalicylic acid is a noncompetitive estrone sulfatase inhibitor with IC50 of 0.15 mM and Ki of 0.12 mM.
3.17二丙酸17Β雌二酯 V11151 Estradiol dipropionate 113-38-2 Estradiol dipropionate is an estrogen-progesterone combination that works as an estrogen and progesterone agonist.
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone V67711 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone 151752-07-7 4',2-Dihydroxy-4,6-dimethoxydihydrochalcone is an estrogen agonist with binding affinity to bovine uterine estrogen receptors with IC50 of 15 μM [1].
4,4'-(Cyclohexylidenemethylene)diphenol V107243 4,4'-(Cyclohexylidenemethylene)diphenol 5189-40-2 4,4'-(Cyclohexylmethoxy)diphenol (Compound 2) is a symmetrical cyclic nonsteroidal estrogen.
4-Nonylphenol-d5 (4-n-Nonylphenol-2,3,5,6-d4,OD) V67658 4-Nonylphenol-d5 (4-n-Nonylphenol-2,3,5,6-d4,OD) 358730-95-7 4-Nonylphenol-d5 is the deuterated form of 4-Nonylphenol.
6:2 Cl-PFAES V107193 6:2 Cl-PFAES 73606-19-6 6:2 Cl-PFAES is reproductively toxic.
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) V67720 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 25848-69-5 7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) binds to ERβ and has anti~inflammatory and neuro-protective (neuro-protection) properties.
ADX61623 V93836 ADX61623 1067189-44-9 ADX61623 is a potent negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR).
Antiproliferative agent-51 V101569 Antiproliferative agent-51 Antiproliferative agent-51 (Compound 18h) inhibits estrogen receptor α (ERα)-mediated transcription with IC50 of 1.6 nM.
Arzoxifene (LY353381; SERM III) V67687 Arzoxifene (LY353381; SERM III) 182133-25-1 Arzoxifene (LY353381) is an orally bioactive selective estrogen receptor modulator with a fixed ring structure similar to raloxifene.
AZD9496 V2554 AZD9496 1639042-08-2 AZD9496 is a novel, potent, orally bioavailable, and selective estrogen receptor (ERα) downregulator and antagonist with an IC50 of 0.28 nM and a Ki of 0.7 nM.
AZD9496马来酸盐 V2643 AZD9496 maleate 1639042-28-6 AZD9496 (AZD-9496) maleate is a novel, potent, orally bioavailable, andselective estrogen receptor (ERα) downregulator and antagonist with anticancer activity.
Bazedoxifene-d4 acetate (TSE-424-d4 acetate) V67699 Bazedoxifene-d4 acetate (TSE-424-d4 acetate) 1795027-71-2 Bazedoxifene-d4 (acetate) is the deuterated form of Bazedoxifene.
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