Tyrosinase

Tyrosinase

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases.Tyrosinases are the mammalian enzymes that initiate the production of melanin, the pigment that gives skin and hair their color, as well as the browning of fruits and vegetables after cell damage.

Tyrosinases are involved in pigmentation, wound healing, radiation protection, and the initial immune response. They are present in a variety of prokaryotes in addition to plants, fungi, arthropods, and mammals. The hydroxylation of monophenols and the oxidation of diphenols by tyrosinases results in quinones, which spontaneously polymerize to form melanin. Tyrosinases are crucial for wound healing and basic immune responses in plants, sponges, and a variety of invertebrates; they also aid in sclerotization in arthropods; and they shield DNA from UV ray damage in bacteria.

Tyrosinase related products

Structure Cat No. Product Name CAS No. Product Description
V71954 (-)-Taxifolin ((-)-Dihydroquercetin; (-)-Dihydroquercetin) 111003-33-9 (-)-Taxifolin is the less active isomer of Taxifolin.
V84431 (±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3)
V71939 2-Methoxycinnamic acid 6099-03-2 2-Methoxycinnamic acid is a noncompetitive tyrosinase inhibitor.
V71935 3-O-Ethyl-L-ascorbic acid (vitamin C ethyl ether) 86404-04-8 3-O-Ethyl-L-ascorbic acid, a stable vitamin C analogue, is a cosmetic tyrosinase inhibitor (antagonist) with whitening ability.
V71962 4-Ethylresorcinol 2896-60-8 4-Ethylresorcinol is an analogue of resorcinol that serves as a substrate for tyrosinase.
V51532 5-epi-Arvestonate A 2767066-84-0 5-epi-Arvestonate A is a sesquiterpenoid extracted from Seriphidium transiliense.
V71937 5-Feruloylquinic acid 40242-06-6 5-Feruloylquinic acid (5-FQA) has antioxidant and tyrosinase inhibitory activities.
V71945 6-Hydroxykaempferol 4324-55-4 6-Hydroxykaempferol, a flavonoid, is a competitive tyrosinase inhibitor (antagonist) with IC50 of 124 μM.
V71946 7-Methoxy obtusifolin 1820806-09-4 7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor (antagonist) with IC50 of 7.0 μM.
V71949 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 82188-67-8 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanogen, a hormone that stimulates melanocytes.
V71963 Allamadicin 51838-83-6 Allamadicin is an iridoid lactone.
V71944 Azo-resveratrol 1393556-48-3 Azo-resveratrol is an azo compound that can inhibit mushroom tyrosinase (IC50=36.28 μM).
V71932 Broussonin C 76045-49-3 Broussonin C is a competitive inhibitor of Tyrosinase and can be extracted from Broussonetia kazinoki.
V71956 Chlorogenic acid butyl ester 132741-56-1 Chlorogenic acid butyl ester is a caffeoylquinic acid, a potent melanogenesis inhibitor.
V71941 Cyclocommunol 145643-96-5 Cyclocommunol is an amyl flavonoid with antityrosinase and antiplatelet activity extracted from breadfruit.
V71964 Diaminopropionoyl tripeptide-33 1199495-15-2 Diaminopropionoyl tripeptide-33 is a biologically active peptide that has the effect of protecting skin cells from UVA-induced DNA damage and has been reported for use as a cosmetic ingredient.
V71952 Dodoviscin A 1372527-25-7 Dodoviscin A is a pigmentation-altering agent extracted from the aerial parts of Dodonaea viscosa.
V71965 ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a tyrosinase inhibitor against melanin synthesis that can be extracted from Pteris fern.
V71943 Flanvotumab (IMC-20D7S) 1188277-05-5 Flanvotumab (IMC-20D7S) is a human monoclonal antibody (mAb) targeting tyrosinase-related protein (TYRP1), which is specifically expressed on melanocytes and melanoma cells.
V71947 hTYR/AbTYR-IN-1 1625821-37-5 hTYR/AbTYR-IN-1 (Compound 7) is a hTYR/AbTYR dual (bifunctional) inhibitor (antagonist) with IC50 of 5.4 μM and 3.52 μM for hTYR and AbTYR, respectively.
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