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MMP

MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands. Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells.It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.

MMP related products

Structure Cat No. Product Name CAS No. Product Description
(2R)-RXP470.1 V121428 (2R)-RXP470.1 (2R)-RXP470.1 is the (2R)-isomer of RXP470.1.
(E)-N-(3-Methoxyphenyl)cinnamamide V121775 (E)-N-(3-Methoxyphenyl)cinnamamide 127033-74-3 (E)-N-(3-Methoxyphenyl)cinnamamide is a weakly selective inhibitor of MMP-2 and MMP-9, with weak inhibitory activity against hMMP-2 and hMMP-9, with IC50 values of 1674.81 nM and 1658.63 nM, respectively, and low selectivity for MMP-1.
(R)-MMP408 V121945 (R)-MMP408 1258003-93-8 (R)-MMP408 is an orally effective MMP-12 inhibitor (IC50 for hMMP-12 = 2.0 nM) that effectively interferes with the epithelial-mesenchymal transition (EMT) process.
14-3-3-IN-2 V117198 14-3-3-IN-2 919751-10-3 14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC50 value of 15 nM.
3,3′-Bisdemethylpinoresinol V73262 3,3′-Bisdemethylpinoresinol 340167-81-9 3,3′-Bisdemethylpinoresinol, lignin, is a naturally occurring compound with MMP-1 inhibitory activity on UVA-irradiated human dermal fibroblasts.
3-Aminobenzene-1,2-diol V105509 3-Aminobenzene-1,2-diol 20734-66-1 3-Aminobenzene-1,2-diol (Compound C8) is a matrix metalloproteinase (MMP) inhibitor with IC50 values of 20, 26, 16, and 16.3 μM for MMP-2, MMP-8, MMP-9, and MMP-14, respectively.
3-Hydroxy-2-pyrone V111850 3-Hydroxy-2-pyrone 496-64-0 3-Hydroxy-2-pyranone (compound 12d) is a metalloenzyme inhibitor.
4-Epianhydrochlortetracycline hydrochloride V102751 4-Epianhydrochlortetracycline hydrochloride 158018-53-2 4-epitope chlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), especially gelatinase B (EC 3.4.24.35), with an inhibition rate of 100% at 500μg/mL, 70% at 125μg/mL, and 40% at 31μg/mL.
6-epi Doxycycline V127388 6-epi Doxycycline 3219-99-6 6-epi Doxycycline is the C-6 epimer of doxycycline and is a degradation impurity resulting from the epimerization of doxycycline under abnormal conditions (such as high temperature, pH changes, or high humidity).
ABX-MA1 V128057 ABX-MA1 561063-60-3 ABX-MA1 is a humanized IgG2 monoclonal antibody inhibitor that targets MCAM/MUC18.
ADAM17-IN-1 V118457 ADAM17-IN-1 1802395-34-1 ADAM17-IN-1 is a selective ADAM17 inhibitor.
AG73 V128389 AG73 170655-66-0 AG73 is a polypeptide derived from the G domain of the laminin α1 chain.
Ageladine A dihydrochloride V128396 Ageladine A dihydrochloride 2757574-06-2 Ageladine A dihydrochloride is a matrix metalloproteinase (MMP) inhibitor isolated from marine sponges, and it has anti-angiogenic activity.
Anticancer agent 204 V128952 Anticancer agent 204 Anticancer agent 204 is a fluorinated cinnamamide derivative with anticancer activity.
ASPH-IN-1 V111197 ASPH-IN-1 2477878-52-5 ASPH-IN-1 (compound 14c) is an orally effective ASPH inhibitor.
Berkeleyamide B V118664 Berkeleyamide B 1019854-22-8 Berkeleyamide B is a dual inhibitor of metalloproteinase-3 (MMP-3) and caspase-1.
Berkeleyamide C V118461 Berkeleyamide C 1019854-23-9 Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1.
BHQ-3 carboxylic acid chloride V130124 BHQ-3 carboxylic acid chloride BHQ-3 carboxylic acid chloride is a dark fluorescence quencher containing an azo group.
BJ-2302 V130364 BJ-2302 1631056-29-5 BJ-2302 is a Src kinase inhibitor with an IC50 value of 3.23 μM that inhibits the activity of cathepsin S (CTSS).
BT1769 acetate V130703 BT1769 acetate BT1769 acetate is a conjugate antitumor drug targeting MT1-MMP, with a Kd value of 3.35 nM for the human target.
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