MicroRNAs (miRNAs) are a class of small, naturally occurring non-coding RNAs that control post-transcriptional gene expression to regulate cellular functions, development, cell differentiation, and homeostasis. They are about 22 nucleotides long. Since microRNAs control cell differentiation, proliferation, and apoptosis, they are crucial for the development of embryos, cells, and tissues, which explains their significance in human reproduction. Meanwhile, it has been discovered that abnormal miRNA expression or function is closely linked to the occurrence or progression of a number of human diseases, including cancers. MiRNAs are emerging as novel biomolecular targets for chemical-biological studies, including regulation and detection, given their significant roles in physiology and pathology.
The production of miRNAs involves a number of steps. The canonical biogenesis pathway, which produces the majority of miRNAs, involves RNA polymerase II transcription to create a primary transcript (pri-miRNA) and microprocessor complex cleavage to create a hairpin precursor miRNA (pre-miRNA) in the nucleus.Following export into the cytoplasm, the enzyme Dicer cleaves the pre-miRNA to produce a double-stranded RNA duplex. AGO proteins in the RNA-induced silencing complex (RISC) are guided in their binding to the 3' untranslated region (UTR) to either repress protein translation or promote mRNA degradation by the mature miRNA, which is only one strand of the double-stranded RNA duplex.There are non-canonical microprocessor- or Dicer-independent miRNA biogenesis pathways in addition to the canonical miRNA biogenesis pathways. There have been reports of miRNAs promoting gene expression, despite the fact that miRNAs are primarily involved in the down-regulation of gene expression. Furthermore, in a particular cell type, the relationships between miRNAs and their targets are not always 1:1. In actuality, a single miRNA may control a large number of mRNA targets, and vice versa, a single mRNA target may also be controlled by a large number of miRNAs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V51641 | Camptothecin-d5 | 1329616-37-6 | Camptothecin-d5 is the deuterated form of camptothecin. |
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V51530 | Cobomarsen (MRG-106) | 1848257-52-2 | Cobomarsen (MRG-106) is an oligonucleotide multiple of miR-155. |
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V79283 | Eldocasiran sodium | Eldocasiran sodium is a micro-ARN-193a-3p analog, and Eldocasir has anti-cancer effect and may be utilized in cancer-related research. | |
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V55747 | Lademirsen (SAR339375; RG-012) | 1404019-95-9 | Lademirsen (SAR339375; RG-012) is an oligonucleotide that targets miR-21 and inhibits its function. |
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V33118 | LIN28 inhibitor LI71 | 1357248-83-9 | LIN28 inhibitor LI71 is a potent ,novel and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. |
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V80775 | MicroRNA Antagomir Negative Control | MicroRNA Antagomir negative control (NC) is a specially chemically modified oligonucleotide single chain. | |
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V80776 | MicroRNA Inhibitor Negative Control | MicroRNA Inhibitor negative control (NC) is a fully methoxy-modified single-stranded oligonucleotide (21 nucleotides in length) that could be utilized as a negative control (NC) for miRNA inhibitors. | |
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V80777 | MicroRNA Mimic Negative Control | MicroRNA Mimic negative control (NC) is a 21-nucleotide miRNA mimic that can be used as a negative control (NC). | |
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V41197 | microRNA-21-IN-2 | 303018-40-8 | microRNA-21-IN-2 is a potential inhibitor of miR-21 with an AC50 value of 3.29 μM. |
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V81090 | mmu-let-7a-1-3p agomir | mmu-let-7a-1-3p agomir is a specially chemically modified miRNA mimic. | |
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V81091 | mmu-let-7a-1-3p antagomir | mmu-let-7a-1-3p antagomir is a complementary single strand of mature miRNA that has been specially chemically modified. | |
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V81092 | mmu-let-7a-1-3p inhibitor | mmu-let-7a-1-3p inhibitor is a complementary single-stranded mature miRNA whose entire chain has been modified with methoxy groups. | |
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V81093 | mmu-let-7a-2-3p agomir | mmu-let-7a-2-3p agomir is a specially chemically modified miRNA mimic. | |
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V81094 | mmu-let-7a-2-3p antagomir | mmu-let-7a-2-3p antagomir is a complementary single-stranded mature miRNA that has been specially chemically modified. | |
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V81096 | mmu-let-7a-2-3p inhibitor | mmu-let-7a-2-3p inhibitor is a complementary single-stranded mature miRNA whose entire chain has been modified with methoxy groups. | |
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V81097 | mmu-let-7f-2-3p agomir | mmu-let-7f-2-3p agomir is a specially chemically modified miRNA mimic. | |
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V81098 | mmu-let-7f-2-3p antagomir | mmu-let-7f-2-3p antagomir is a complementary single-stranded mature miRNA that has been specially chemically modified. | |
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V81099 | mmu-let-7f-2-3p inhibitor | mmu-let-7f-2-3p inhibitor is a complementary single-stranded mature miRNA whose entire chain has been modified with methoxy groups. | |
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V81100 | mmu-let-7j agomir | mmu-let-7j agomir is a specially chemically modified miRNA mimic. | |
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V80797 | mmu-let-7j antagomir | mmu-let-7j antagomir is a complementary single strand of mature miRNA that has been specially chemically modified. |
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