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MicroRNA

MicroRNA

MicroRNAs (miRNAs) are a class of small, naturally occurring non-coding RNAs that control post-transcriptional gene expression to regulate cellular functions, development, cell differentiation, and homeostasis. They are about 22 nucleotides long. Since microRNAs control cell differentiation, proliferation, and apoptosis, they are crucial for the development of embryos, cells, and tissues, which explains their significance in human reproduction. Meanwhile, it has been discovered that abnormal miRNA expression or function is closely linked to the occurrence or progression of a number of human diseases, including cancers. MiRNAs are emerging as novel biomolecular targets for chemical-biological studies, including regulation and detection, given their significant roles in physiology and pathology.
The production of miRNAs involves a number of steps. The canonical biogenesis pathway, which produces the majority of miRNAs, involves RNA polymerase II transcription to create a primary transcript (pri-miRNA) and microprocessor complex cleavage to create a hairpin precursor miRNA (pre-miRNA) in the nucleus.Following export into the cytoplasm, the enzyme Dicer cleaves the pre-miRNA to produce a double-stranded RNA duplex. AGO proteins in the RNA-induced silencing complex (RISC) are guided in their binding to the 3' untranslated region (UTR) to either repress protein translation or promote mRNA degradation by the mature miRNA, which is only one strand of the double-stranded RNA duplex.There are non-canonical microprocessor- or Dicer-independent miRNA biogenesis pathways in addition to the canonical miRNA biogenesis pathways. There have been reports of miRNAs promoting gene expression, despite the fact that miRNAs are primarily involved in the down-regulation of gene expression. Furthermore, in a particular cell type, the relationships between miRNAs and their targets are not always 1:1. In actuality, a single miRNA may control a large number of mRNA targets, and vice versa, a single mRNA target may also be controlled by a large number of miRNAs.

MicroRNA related products

Structure Cat No. Product Name CAS No. Product Description
Camptothecin-d5 V51641 Camptothecin-d5 1329616-37-6 Camptothecin-d5 is the deuterated form of camptothecin.
Cobomarsen (MRG-106) V51530 Cobomarsen (MRG-106) 1848257-52-2 Cobomarsen (MRG-106) is an oligonucleotide multiple of miR-155.
Cobomarsen sodium V90327 Cobomarsen sodium 1848257-85-1 Cobomarsen sodium is an oligonucleotide inhibitor of miR-155 and can be used in the study of B-cell lymphoma.
Eldocasiran sodium V79283 Eldocasiran sodium Eldocasiran sodium is a micro-ARN-193a-3p analog, and Eldocasir has anti-cancer effect and may be utilized in cancer-related research.
hsa-let-7a-2-3p antagomir V89464 hsa-let-7a-2-3p antagomir Hsa-let-7a-2-3p antagomir is a complementary single strand of mature miRNA that has undergone special chemical modification.
hsa-let-7a-2-3p inhibitor V89548 hsa-let-7a-2-3p inhibitor hsa-let-7a-2-3p inhibitor is a complementary single strand of mature miRNA that has been fully methoxylated.
hsa-let-7a-2-3p mimic V89468 hsa-let-7a-2-3p mimic hsa-let-7a-2-3p mimic is a chemically synthesized miRNA mimic that can mimic endogenous miRNA, upregulate miRNA activity, and is used in gain-of-function studies.
hsa-let-7a-5p mimic V89552 hsa-let-7a-5p mimic hsa-let-7a-5p mimic is a chemically synthesized miRNA mimic that can mimic endogenous miRNA, upregulate miRNA activity, and is used in gain-of-function studies.
hsa-let-7c-3p antagomir V89503 hsa-let-7c-3p antagomir Hsa-let-7c-3p antagomir is a complementary single strand of mature miRNA that has been specially chemically modified.
hsa-let-7c-3p inhibitor V89544 hsa-let-7c-3p inhibitor hsa-let-7c-3p inhibitor is a complementary single strand of mature miRNA that is fully methoxy-modified.
hsa-let-7e-3p mimic V89593 hsa-let-7e-3p mimic hsa-let-7e-3p mimic is a chemically synthesized miRNA mimic that can mimic endogenous miRNA, upregulate miRNA activity, and is used for gain-of-function studies.
hsa-let-7f-1-3p antagomir V89493 hsa-let-7f-1-3p antagomir Hsa-let-7f-1-3p antagomir is a complementary single strand of mature miRNA that has been specially chemically modified.
hsa-let-7f-1-3p inhibitor V89550 hsa-let-7f-1-3p inhibitor hsa-let-7f-1-3p inhibitor is a complementary single strand of mature miRNA that has been fully methoxylated.
hsa-let-7f-2-3p antagomir V89614 hsa-let-7f-2-3p antagomir Hsa-let-7f-2-3p antagomir is a complementary single strand of mature miRNA that has been specially chemically modified.
hsa-let-7g-5p inhibitor V89489 hsa-let-7g-5p inhibitor hsa-let-7g-5p inhibitor is a complementary single strand of mature miRNA that is fully methoxy-modified.
Lademirsen (SAR339375; RG-012) V55747 Lademirsen (SAR339375; RG-012) 1404019-95-9 Lademirsen (SAR339375; RG-012) is an oligonucleotide that targets miR-21 and inhibits its function.
LIN28 inhibitor LI71 V33118 LIN28 inhibitor LI71 1357248-83-9 LIN28 inhibitor LI71 is a potent ,novel and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.
MG-1102 V83674 MG-1102 2567913-75-9
MicroRNA Antagomir Negative Control V80775 MicroRNA Antagomir Negative Control MicroRNA Antagomir negative control (NC) is a specially chemically modified oligonucleotide single chain.
MicroRNA Inhibitor Negative Control V80776 MicroRNA Inhibitor Negative Control MicroRNA Inhibitor negative control (NC) is a fully methoxy-modified single-stranded oligonucleotide (21 nucleotides in length) that could be utilized as a negative control (NC) for miRNA inhibitors.
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