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NAMPT

NAMPT

The mammalian nicotinamide adenine dinucleotide (NAD+) synthetic salvage pathway uses nicotinamide phosphoribosyltransferase (NAMPT) as the rate-limiting enzyme to catalyze the conversion of nicotinamide (NAM) and phosphoribosyl-pyrophosphates to nicotinamide mononucleotide (NMN). NAMPT is found in two different forms: extracellular (eNAMPT) and intracellular (iNAMPT).
Brown adipose tissue (BAT), liver, and kidney have high iNAMPT levels; white adipose tissue (WAT), lung, spleen, testes, and skeletal muscle have intermediate levels; and the brain and pancreas have undetectable iNAMPT levels. The release of eNAMPT into plasma, which is thought to result from post-translational modification of iNAMPT, is primarily caused by adipose tissue. There, it catalyzes the synthesis of NMN. Although eNAMPT has been reported to function as a cytokine with numerous roles in physiology and pathology, intracellular NAMPT is a key enzyme in controlling NAD metabolism. Cancer and other metabolic and inflammatory diseases have been linked to circulating eNAMPT.

NAMPT related products

Structure Cat No. Product Name CAS No. Product Description
Anticancer agent 177 V85413 Anticancer agent 177
Antitumor agent-136 V84331 Antitumor agent-136 2484876-94-8
GMX1778 (CHS828) V0961 GMX1778 (CHS828) 200484-11-3 GMX1778 (GMX 1778;CHS828; GMX-1778;CHS-828) is a potent and selective/specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential antitumor activity.
GNE-617 V0098 GNE-617 1362154-70-8 GNE-617 is a novel, potent and specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer.
GNE-617 hydrochloride V2814 GNE-617 hydrochloride 2070014-99-0 GNE-617 hydrochloride is a specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer.
GNE-617 hydrochloride V72007 GNE-617 hydrochloride 2070014-99-0 GNE-617 HCl is a specific NAMPT inhibitor that can suppress NAMPT activity with IC50 of 5 nM.
HDAC/NAMPT-IN-1 V84843 HDAC/NAMPT-IN-1 2898381-63-8
JGB-1-155 V83679 JGB-1-155 3011930-28-9
LB-60-OF61 hydrochloride V51686 LB-60-OF61 hydrochloride 742064-38-6 LB-60-OF61 HCl is a potent NAMPT inhibitor and LB-60-OF61 HCl is a cytotoxic compound selective for MYC-overexpressing cell lines.
Manidipine (CV-4093) V0959 Manidipine (CV-4093) 89226-50-6 Manidipine (formerly CV-4093; CV 4093; CV4093), a calcium channel blocker (CCB) of the dihydropyridine class, is an approved drug that has been used clinically as an antihypertensive agent.
Nampt activator-1 V51682 Nampt activator-1 701929-65-9 Nampt activator-1 (compound 1) is a potent activator of nicotinamide phosphotransferase (NAMPT) with EC50 of 3.3-3.7 μM.
Nampt activator-2 V51683 Nampt activator-2 2237268-90-3 Nampt activator-2 (compound 34) is a potent NAMPT activator with EC50 of 0.023 μM.
Nampt activator-3 V51680 Nampt activator-3 2790481-63-7 NAMPT activator-3 is a NAT mimetic and a NAMPT activator with EC50 of 2.6 μM and a KD of 132 nM.
Nampt activator-4 V85400 Nampt activator-4 2847156-05-0
Nampt activator-5 V83394 Nampt activator-5
NAMPT degrader-3 V51681 NAMPT degrader-3 NAMPT degrader-3 (compound C5) is a NAMPT degrader that depends on VHL and proteasomal means.
Nampt-IN-10 trihydrochloride V80893 Nampt-IN-10 trihydrochloride Nampt-IN-10 tri HCl (compound 4) is an inhibitor (blocker/antagonist) of phosphoribosyltransferase (NAMPT).
NAMPT/IDO1-IN-1 V51684 NAMPT/IDO1-IN-1 2247884-06-4 NAMPT/IDO1-IN-1 is a vascular wall-potent, two-fold inhibitor of NAMPT and IDO1 with IC50 of 57.5 nM and 233 nM, respectively.
P7C3 V0960 P7C3 301353-96-8 P7C3 (P-7C3;P7 C-3;P 7C3) is a novel and potent proneurogenic and neuroprotective agent that acts by targeting the NAMPT (Nicotinamide phosphoribosyltransferase) enzyme.
Padnarsertib (KPT-9274) V3144 Padnarsertib (KPT-9274) 1643913-93-2 Padnarsertib (KPT-9274; KPT9274; PAK4-IN-1) is a potent, selective,orally bioavailablesmall molecule,non-competitive dual inhibitor of PAK4/NAMPT inhibitor with anticancer activity.
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