Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Eukaryotic cells use dynamins to scissor (cleave the vesicle from the parent membrane) developing vesicles from parent membranes. Dynamins sever and release coated vesicles by directly interacting with the lipid bilayer at the necks of clathrin-coated pits. While dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains, dynamins have five domains, including the GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD).Several different cellular processes, such as cytokinesis and membrane fission in plant cells (Arabidopsis thalianaDRP proteins), pathogen resistance, vacuolar fission in yeast (Saccharomyces cerevisiae Vps1), and interferon-induced antiviral protection (fish Mx proteins) are all regulated by dynamins and DRPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52244 | Clathrin-IN-2 | 2650733-69-8 | Clathrin-IN-2 is a potent inhibitor of clathrin-mediated endocytosis (CME) with IC50 of 2.3 μM. |
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V56038 | Clathrin-IN-4 | 762242-59-1 | Clathrin-IN-4 (compound 8b) is an analogue of Wiskostatin , a potent clathrin-mediated endocytosis (endocytosis) inhibitor (antagonist) with IC50 of 2.1 μM. |
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V52158 | DRP1i27 | 1453028-33-5 | DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). |
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V77065 | DRP1i27 dihydrochloride | DRP1i27 di-HCl is a potent inhibitor of human Drp1 (dynamin-related protein 1). | |
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V56040 | Dynamin IN-1 | 1345853-50-0 | Dynamin IN-1 is a potent dynamin inhibitor (antagonist) with IC50 of 1.0 µM. |
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V56039 | Dynamin IN-2 | 1345853-49-7 | Dynamin IN-2 (compound 43), a Wiskostatin analogue, is a potent dynamin inhibitor against dynamin I GTPase The IC50 is 1.0 μM. |
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V52149 | Dynamin inhibitory peptide | 251634-21-6 | Dynamin inhibitory peptide competitively blocks the binding of dynamin to amphoteric fibrin, thereby preventing endocytosis. |
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V79228 | Dynamin inhibitory peptide TFA | Dynamin inhibitory peptide TFA competitively blocks the binding of dynamin to amphoteric fibrin, thereby preventing endocytosis. | |
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V56037 | DynaMin inhibitory peptide, myristoylated | 251634-22-7 | DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor that interferes with the binding of amphotericin (amphiphysin) and dynamin (dynamin). |
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V79229 | DynaMin inhibitory peptide, myristoylated TFA | DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor that interferes with the binding of amphotericin (amphiphysin) and dynamin (dynamin). | |
|
V52148 | Dynapyrazole-A | 2226517-75-3 | Dynapyrazole A is a specific inhibitor of microtubule dynein that specifically inhibits the ATPase activity of microtubule-stimulated dynein but does not block the microtubule-independent basal activity. |
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V1592 | Dyngo-4a | 1256493-34-1 | Dyngo-4a (Dyngo 4a; Hydroxy Dynasore) is a potent and novel dynamin inhibitor with the potential to treatbotulism. |
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V53404 | Dynole 2−24 | 1416313-72-8 | Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50 for dynamin I=0.56 μM). |
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V51316 | Dynole 34-2 | 1128165-88-7 | Dynole 34-2 is a dynamin GTPase (IC50 for dynamin 1 and dynamin 2 GTPase activity of 6.9 and 14.2 µM, respectively) with antimitotic effects. |
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V88807 | P110 | 1411976-18-5 | P110 is a peptide inhibitor of the Drp1-Fis1 interaction that reduces pathological functions in many neurodegeneration, ischemia, and sepsis models without blocking the physiological function of Drp1. |
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V88809 | Pyrimidyn 7 | 1440126-94-2 | Pyrimidyn 7 is a dynamin I/II inhibitor with IC50 values of 1.1 μM and 1.8 μM, respectively. |
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V88808 | TAT-P110 | TAT-P110 is a peptide inhibitor that inhibits the Drp1-Fis1 interaction and reduces pathological changes in multiple neurodegenerative disease, ischemia, and sepsis models without impeding the physiological function of Drp1. | |
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V34758 | Trimethyloctadecylammonium bromide | 1120-02-1 | Trimethyloctadecylammonium bromide is a dynamin inhibitor (antagonist) with IC50 of 1.9 μM. |
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V1590 | Dynasore | 304448-55-3 | Dynasore is a cell-permeable, reversible and non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2 (IC50 = 15 μM) with cardioprotective effects. |
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V1591 | Mdivi-1 (Mitochondrial division inhibitor 1) | 338967-87-6 | Mdivi-1 (Mitochondrial Division Inhibitor 1; Mdivi 1; Mdivi1) is a potent selective and cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with the potential for treating stroke, myocardial infarction, and neurodegenerative disease. |
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