The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1155 | Tolazoline HCl | 59-97-2 | Tolazoline HCl (Pridazole, Priscol,Benzalolin, Divascol, Priscoline), the hydrochloride salt of tolazoline, is an imidazolline-based and non-selective competitive α-adrenergic receptor antagonist used as a vasodilator for the treatment of spasms of peripheral blood vessels. |
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V71334 | Trecadrine (Trecadrinum) | 90845-56-0 | Trecadrine is a beta3-adrenergic agonist. |
|
V71273 | Tulobuterol-d9 hydrochloride (C-78-d9) | 1325559-14-5 | Tulobuterol-d9 ( HCl) is the deuterated form of Tulobuterol. |
|
V71261 | Vemtoberant (APD418) | 2169905-68-2 | Vemtoberant is a beta3 adrenergic receptor blocker (antagonist). |
|
V71259 | Vemtoberant mesylate (APD418 mesylate) | 2169905-97-7 | Vemtoberant mesylate is a beta3 adrenergic receptor antagonist. |
|
V30386 | Vilanterol | 503068-34-6 | Vilanterol (GW 642444; GW642444; GW-642444) is a long-acting β2-adrenoceptor/ beta-2 (β2-AR) agonist approved in May 2013 for use in combination with fluticasone furoate in the treatment of chronic obstructive pulmonary disease (COPD). |
|
V4946 | Vilanterol trifenatate | 503070-58-4 | Vilanterol trifenatate (formerly GW-642444; Anoro Ellipta; Breo Ellipta), thetrifenatate salt of vilanterol,is an ultra-long-acting β2-adrenoceptor/ beta-2 (β2-AR) agonist approved in May 2013 for use in combination with fluticasone furoate (Breo Ellipta) and also in combination with Umeclidinium bromide (Anoro Ellipta) for the treatment of chronic obstructive pulmonary disease (COPD). |
|
V28307 | Xylazine | 7361-61-7 | Xylazine, an analogue of clonidine,is an α2-Adrenergic receptor agonist used for the treatment of sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
|
V1080 | Xylazine HCl (BAY 1470 HCl) | 23076-35-9 | Xylazine HCl (Anased; BAY 1470; BAY-1470; Primazine; Rometar; Sedomin; WH-7286; Xilazina), the hydrochloride salt of xylazine and an analogue of clonidine,is an α2-Adrenergic receptor agonist that has been approved as aVeterinarian drug and used for sedation, muscle relaxation,anesthesia, and analgesia in big animals such as horses, cattles and other non-human mammals. |
|
V1125 | Xylometazoline HCl | 1218-35-5 | Xylometazoline HCl (xylomethazoline; Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal),the hydrochloride salt of Xylometazoline, is an α-adrenoceptor agonist commonly used as nasal decongestant. |
|
V1127 | Yohimbine HCl | 65-19-0 | Yohimbine HCl (Antagonil; Corynine; Quebrachin; Quebrachine; Yohimex; Yocon; APHRODINE; Aphrodyne; Aphrosol; Johimbin),the hydrochloride salt ofYohimbine, is a potent alpha 2-adrenoreceptor antagonist used as a mydriatic for the treatment of impotence. |
|
V71256 | Yohimbine-13C,d3 (Yohimbine 13C,d3) | 1261254-59-4 | Yohimbine-13C,d3 is a 13C- and deuterium labelled Yohimbine. |
|
V3431 | Zenidolol (ICI-118551) HCl | 72795-01-8 | ICI-118551 HCl, the hydrochloride salt of ICI118551, is a novel, potent and highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. |
|
V70535 | β2AR/M3-receptor agonist-1 | 1206887-00-4 | β2AR/M3-receptor agonist-1 (example 9) is a potent β2AR and M3 receptor agonist. |
|
V80231 | β2ARagonist 2 | β2AR agonist 2 (compound 8a) is a β2-adrenergic receptor (β2AR) agonist. | |
|
V71287 | β2ARagonist 3 | 2304455-74-9 | β2AR agonist 3 (compound 9a) is a β2-adrenergic receptor (β2AR) agonist. |
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