Ferroptosis is a non-apoptotic form of regulated cell death.It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3. Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.

Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.

Ferroptosis related products

Structure Cat No. Product Name CAS No. Product Description
Erastin V0954 Erastin 571203-78-6 Erastin is acell-permeable small molecule and potent ferroptosis activator by acting on mitochondrial VDAC with potential antineoplastic activity.
Ferrostatin-1 (Fer-1) V0955 Ferrostatin-1 (Fer-1) 347174-05-4 Ferrostatin-1 (also named as Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
Liproxstatin-1 V0956 Liproxstatin-1 950455-15-9 Liproxstatin-1 (Lip-1) is a novel and potent inhibitor of ferroptosis with important biological activity.
PUN-30119 V4648 PUN-30119 1801530-11-9 Imidazole ketone erastin (IKE) or PUN30119 is a novel, potent, selective,and metabolically stable inhibitor of the cystine-glutamate antiporter,system Xc-and an activator offerroptosis.
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