Ferroptosis is a non-apoptotic form of regulated cell death.It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3. Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.
Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0954 | Erastin | 571203-78-6 | Erastin is acell-permeable small molecule and potent ferroptosis activator by acting on mitochondrial VDAC with potential antineoplastic activity. |
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V0955 | Ferrostatin-1 (Fer-1) | 347174-05-4 | Ferrostatin-1 (also named as Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
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V0956 | Liproxstatin-1 | 950455-15-9 | Liproxstatin-1 (Lip-1) is a novel and potent inhibitor of ferroptosis with important biological activity. |
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V4648 | PUN-30119 | 1801530-11-9 | Imidazole ketone erastin (IKE) or PUN30119 is a novel, potent, selective,and metabolically stable inhibitor of the cystine-glutamate antiporter,system Xc-and an activator offerroptosis. |
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