The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1136 | L-Adrenaline | 51-43-4 | L-Adrenaline (L-epinephrine; Adrenalin; Levoepinephrine; Epitrate; Lyophrin; Medihaler-Epi), the levo-isomer of adrenaline, belongs to a group of the compounds known as catecholamines. |
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V22445 | Labetalol (AH-5158; Sch-15719W) | 36894-69-6 | Labetalol (AH5158; Sch15719W) is a potent, competitive, dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors with antihypertensive properties. |
|
V1102 | Labetalol HCl (AH-5158 HCl; Sch-15719W) | 32780-64-6 | Labetalol HCl (ch15719W; AH5158; Normodyne, Albetol, Trandate, Apo-Labetalol, Dilevalol), the hydrochloride salt of Labetalol, is a competitive and dual antagonist of alpha1-adrenergic and beta-adrenergic receptors with potential antihypertensive properties. |
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V4683 | Landiolol HCl | 144481-98-1 | Landiolol (also known as LDLL600 and ONO 1101) is a beta1 selective, ultra-short-acting β1-adrenergic blocker which is useful for managing supraventricular tachyarrhythmias in sepsis. |
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V70538 | LAS190792 (AZD8999) | 1347232-69-2 | LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist for M1, M2, M3, M4, M5, β1, β2, β3 The pIC50s were 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 respectively. |
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V39616 | Levalbuterol | 34391-04-3 | Levalbuterol, (R)-albuterol or the R-isomer of albuterol,is a potent β2-adrenergic receptor agonist used to treat asthma and COPD-chronic obstructive pulmonary disease. |
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V1158 | Levobetaxolol HCl (AL-1577A) | 116209-55-3 | Levobetaxolol HCl ((S)-Betaxolol; AL 1577A; Betaxon; AL-1577A) is the hydrochloride salt of Levobetaxolol which is a potent beta-adrenergic receptor inhibitor /beta blocker with antihypertensive effects. |
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V5252 | Levosalbutamol HCl (Levosalbutamol) | 50293-90-8 | Levosalbutamol (also known as levalbuterol),the R-enantiomer of racemic salbutamol (albuterol),is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). |
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V29734 | Levosalbutamol tartrate (levalbuterol) | 661464-94-4 | Levosalbutamol tartrate (levalbuterol), the tartrate salt of Levosalbutamol which is the R-enantiomer of salbutamol, is a short-acting β2 adrenergic receptor agonist used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). |
|
V3894 | lofexidine | 31036-80-3 | Lofexidine (Lofetensin; Loxacor; brand name Lucemyra among others),an analog of Clonidine, is a medication historically used to treat high blood pressure, but nowadays, it is more commonly used to help with the physical symptoms of opioid withdrawal. |
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V3893 | lofexidine HCl | 21498-08-8 | Lofexidine HCl (Lucemyra) is the hydrochloride salt of lofexidine which is an analog of Clonidine and an α2A adrenergic receptor agonist. |
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V71286 | Lofexidine-d4 hydrochloride (lofexidine d4 hydrochloride (hydrochloride)) | 1206845-57-9 | Lofexidine-d4 ( HCl) is the deuterated form of Lofexidine HCl. |
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V31622 | Lusaperidone | 214548-46-6 | Lusaperidone (R107474; R-107474; R 107474) is a potent α2 adrenergic receptor antagonist with Kis of 0.13 and 0.15 nM for α2A and α2C, respectively. |
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V71324 | Mabuterol-d9 (Mabuterol-d9) | 1246819-58-8 | Mabuterol-d9 is a deuterium labelled form ofMabuterol. |
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V71305 | Mapenterol hydrochloride | 54238-51-6 | Mapenterol HCl is a β2-adrenoceptor agonist. |
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V1116 | Maprotiline HCl | 10347-81-6 | Maprotiline HCl (Psymion; Ludiomil), the hydrochloride salt of Maprotiline which is a tetracyclic antidepressant, is a selective noradrenalin reuptake inhibitor that has been approved for the treatment of depression. |
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V1141 | Medetomidine HCl (MPV-785) | 86347-15-1 | Medetomidine HCl (MPV-785; MPV 785; MPV785; Precedex. Domitor; Selektope) is a selective and synthetic α2-adrenoceptor agonist with analgesic and anesthetic effects. |
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V71310 | Medetomidine-d3 hydrochloride (MPV785-d3) | 1246820-20-1 | Medetomidine-d3 ( HCl) is the deuterated form of Medetomidine HCl. |
|
V71245 | Medroxalol (RMI81968) | 56290-94-9 | Medroxalol (RMI81968) is an orally bioactive adrenergic receptor antagonist that blocks alpha- and beta-adrenergic receptors. |
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V71242 | Meranzin (hesperitone) | 23971-42-8 | Meranzin is a bioactive compound derived from the traditional Chinese medicine Chaihu-Shugan-San (CSS). |
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