Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29488 | (+)-Praeruptorin A | 73069-27-9 | Praeruptorin A [(9S,10S) isomer]is a naturally occurring coumarin derivative isolated from P. |
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V17916 | (-)-Armepavine | 524-20-9 | Armepavine is a bioactive compound from Nelumbo nucifera. |
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V82259 | (S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) | 2341796-77-6 | (S,R,S)-AHPC-C6-NH2 di-HCl (VH032-C6-NH2 di-HCl) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker. |
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V82258 | (S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) | 2341796-80-1 | (S,R,S)-AHPC-C8-NH2 di-HCl (VH032-C8-NH2 di-HCl) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker. |
|
V82295 | 1-Methylxanthine-13C4,15N3 (1-Methylxanthine 13C4,15N3) | 1173018-69-3 | 1-Methylxanthine-13C4,15N3 is a 13C- and 15N (Nitrogen 15)-labelled 1-Methylxanthine. |
|
V32342 | 11-Keto-beta-boswellic acid | 17019-92-0 | 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid), a pentacyclic triterpenic acid of the oleogum resin, is a natural product isolated from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. |
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V82263 | 2'-Deoxyuridine-13C,15N2 (2'-Deoxyuridine-13C,15N2) | 369656-76-8 | 2'-Deoxyuridine-13C,15N2 is 13C (carbon 13) and 15N (nitrogen 15) labelled 2'-Deoxyuridine. |
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V82265 | 2'-Deoxyuridine-d2-1 (2'-Deoxyuridine-d2-1) | 40632-23-3 | 2'-Deoxyuridine-d2-1 is the deuterated form of 2'-Deoxyuridine. |
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V82270 | 2'-O-Methylcytidine-d3 | 2653209-08-4 | 2'-O-Methylcytidine-d3 is deuterium labelled 2'-O-Methylcytidine. |
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V41229 | 3-Sialyllactose sodium | 128596-80-5 | 3'-Sialyllactose (3'-SL) sodium is a prebiotic that maintains immune homeostasis and exerts anti~inflammatory and anti-arthritic effects. |
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V9100 | 4'-O-Methylresveratrol | 33626-08-3 | 4'-O-Methylresveratrol is a novel and potent resveratrol analogue derived from Dipterocarpaceae. |
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V51361 | 7,8-Didehydrocimigenol | 150972-72-8 | triterpenoid |
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V77302 | Ac2-26 ammonium | Ac2-26 ammonium is the N-terminal peptide of annexin 1 and exhibits anti-inflammatory effect. | |
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V77301 | Ac2-26 TFA | Ac2-26 TFA, the active N-terminal peptide of annexin A1 (AnxA1), alleviates ischemia-reperfusion-induced acute lung injury. | |
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V30356 | Aconine | 509-20-6 | Aconine inhibits nuclear factor κB receptor agonist/activator ligand-induced NF-κB activation. |
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V3245 | Adelmidrol | 1675-66-7 | Adelmidrol is a diethanolamide derivative of azelaic acid that exerts potent anti-inflammatory effects that are partly dependent onPPARγ. |
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V82275 | Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) | 61627-67-6 | Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is an insect adipokinetic hormone (AKH) that increases fat body cAMP levels. |
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V82255 | ALPK1-IN-3 | 2765633-73-4 | ALPK1-IN-3 (T007) is an inhibitor (blocker/antagonist) of ALPK1. |
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V0768 | Andrographolide | 5508-58-7 | Andrographolide,a naturally occuring labdane diterpenoid extracted from the stem and leaves of Andrographis paniculata,is anirreversible/covalent NF-κB inhibitor with potential anti-inflammatory activity. |
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V78013 | Anti-inflammatory agent 48 | anti~inflammatory agent 48 is an anti~inflammatory agent that can inhibit the NF-κB signaling pathway and activates HO-1 expression. |
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