Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in larger doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The formation and maintenance of the male sexual phenotype depend heavily on genes that are influenced by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V98841 | (+)-JJ-74-138 | 2135545-34-3 | (+)-JJ-74-138 is a novel noncompetitive androgen receptor (AR) antagonist that inhibits enzalutamide-resistant castration-resistant prostate cancer (CRPC). |
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V89087 | (-)-Erteberel | 533884-08-1 | (-)-Erteberel is a selective estrogen receptor β (ERβ) agonist. |
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V121145 | (–)-JJ-450 | 1998094-23-7 | (–)-JJ-450 is a non-competitive androgen receptor (AR) antagonist. |
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V121529 | (3R,3′R)-Astaxanthin | 60760-95-4 | (3R,3′R)-Astaxanthin is an androgen receptor binding agent. |
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V89074 | (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol | 1393651-00-7 | (3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity. |
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V67625 | (Des-Glu5)-ACTH (1-24) (human, bovine, rat) | 1815617-95-8 | (Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analog of adrenocorticotropic hormone (ACTH). |
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V67597 | (R)-Bicalutamide ((R)-Bicalutamide) | 113299-40-4 | (R)-Bicalutamide is the R-enantiomer of Bicalutamide. |
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V67632 | (R)-SKBG-1 | 2955634-67-8 | (R)-SKBG-1 is an inhibitor (blocker/antagonist) of the RNA-binding protein NONO. |
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V89081 | (R,R)-THC | 221368-54-3 | (R,R)-THC is an ERα agonist and ERβ antagonist, with Ki values of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. |
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V67626 | (Rac)-PF-998425 | 1076225-26-7 | (Rac)-PF-998425 is a specific, non-steroidal androgen receptor (AR) antagonist. |
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V122053 | (rel)-BMS-641988 | 573738-99-5 | (rel)-BMS-641988 is a relative configuration of BMS-641988. |
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V67617 | 11-Ketodihydrotestosterone-d3 (11-KDHT-d3; 5α-Dihydro-11-keto testosterone-d3) DEA controlled substance schedule III | 2479914-02-6 | 11-Ketodihydrotestosterone-d3 is the deuterated form of 11-Ketodihydrotestosterone. |
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V67603 | 11-Ketotestosterone (11-Oxotetestosterone) DEA controlled substance schedule III | 564-35-2 | 11-Ketotestosterone (11-Oxotestosterone), an oxidized form of Testosterone, is an active androgen. |
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V89083 | 17-Epiestriol | 1228-72-4 | 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. |
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V102591 | 19-Noretiocholanolone | 33036-33-8 | 19-Norepinephrine is an androgenic steroid metabolite. |
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V123798 | 2-(2-Methoxyphenoxy)ethylamine hydrochloride | 64464-07-9 | 2-(2-Methoxyphenoxy)ethylamine hydrochloride is a mixed agonist/antagonist. |
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V125392 | 3'-Hydroxy stanozolol | 125709-39-9 | 3'-Hydroxy stanozolol is the main metabolite of the anabolic androgenic steroid stanozolol. |
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V125335 | 3-Cl-Pyridine-amide-acrylaldehyde-piperazine | 3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate for LO-4-25. | |
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V114726 | 3-Oxochol-5-en-24-oic acid | 847232-54-6 | 3-O-5-en-24-acid is a rare bile acid produced by gut microbiota. |
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V125667 | 3βHSD1-IN-1 | 3082852-63-6 | 3βHSD1-IN-1 is an inhibitor of 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) with an IC50 value of 55 nM. |
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