Kinesins are a family of molecular motors that move along the surface of microtubule filaments or cause them to become unstable using the energy from ATP hydrolysis. In humans, there are 45 kinesin proteins spread across 14 different subclasses of the kinesin motor protein family. It has been established that many of these proteins—or their orthologues—have crucial roles to play in both the mitotic and meiotic cell cycles. Based on where their motor domains are located, kinesins can also be divided into three groups: internal, C-terminal, and N-terminal kinesins. Traditional kinesin moves in a coordinated, hand-over-hand manner along a microtubule protofilament, acting as a dimer.
Kinesins play critical roles in the progression of the cell cycle, cytokinesis, spindle formation, microtubule dynamics, and chromosome segregation. Kinesins typically play roles in diseases involving pathogen transport, pathogen transport defects, or cell division.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V1631 | ARQ 621 | 1095253-39-6 | ARQ 621 (ARQ-621; ARQ621) is an allosteric Eg5 mitotic motor protein inhibitor with potential anticancer activity. |
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V1628 | AZ 3146 | 1124329-14-1 | AZ3146 (AZ-3146; AZ3146) is a novel, potent and selective Mps1 kinase (Monopolar spindle1) inhibitor with potential anticancer activity. |
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V1629 | GSK923295 (GSK-923295A) | 1088965-37-0 | GSK923295 (also called GSK-923295;GSK923295A;GSK 923295;GSK-923295A) is a first-in-class, specific and allosteric antimitotic inhibitor of CENP-E (centromere-associated protein E, kinesin motor ATPase)with potential antitumor activity. |
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V1630 | MPI-0479605 | 1246529-32-7 | MPI-0479605 (MPI0479605; MPI 0479605) is an ATP-competitive and selective inhibitor of mitotic kinase Mps1(Monopolar spindle1) with potential antineoplastic activity. |
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V1627 | SB743921 HCl | 940929-33-9 | SB743921 HCl (SB-743921; SB 743921),the hydrochloride salt of SB743921, is a novel and potent inhibitor of the mitotic motor protein, kinesin spindle protein (KSP),with potential antitumor activity. |
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V1626 | Ispinesib (SB-715992) | 336113-53-2 | Ispinesib (formerly also known as CK-0238273, SB-715992), a quinazolinone analog, is anovel,specific and reversible inhibitor of kinesin spindle protein (KSP, a mitotic motor protein) with potential antineoplastic activity. |
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