Fatty Acid Synthase (FASN) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Palmitic acid is produced by the sizable homodimeric multifunctional enzyme known as human fatty acid synthase. Fatty acid synthase's distinctive carboxyl terminal thioesterase domain hydrolyzes the lengthening fatty acid chain and is essential for controlling the amount of fatty acid released. Additionally, the thioesterase is a candidate target for therapeutic intervention due to the up-regulation of human fatty acid synthase in a variety of cancers.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74017 | (−)-C75 | 1234694-22-4 | (−)-C75 is an isomer of C75, a synthetic fatty acid synthase (FASN) inhibitor. |
|
V74019 | Albaspidin AP (Albaspidin AP) | 59092-91-0 | Albaspidin AP inhibits fatty acid synthase (FAS) with IC50 of 71.7 μM. |
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V74020 | Borapetoside E | 151200-49-6 | Borapetoside E can be extracted from T. crispa. |
|
V32051 | C75 trans | 191282-48-1 | C75 trans [(±)-C75] is an isomer/enantiomer of C75 which is a synthetic fatty-acid synthase (FASN) inhibitor. |
|
V78895 | CTL-06 | CTL-06 is an inhibitor (blocker/antagonist) of fatty acid synthase (FASN) (IC50= 3 μM) and can cause apoptosis. | |
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V79541 | CTL-12 | CTL-12 is an inhibitor (blocker/antagonist) of fatty acid synthase (FASN) (IC50= 2.5 μM) and can cause apoptosis. | |
|
V31005 | Desoxyrhaponticin | 30197-14-9 | Desoxyrhaponticin is a novel and potent stilbene glycoside from the Tibetan nutritional foodRheum tanguticumMaxim. |
|
V40353 | Fatostatin hydrochloride | Fatostatin hydrochloride is a novel and potent inhibitor of SREBP. | |
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V34058 | FGH10019 | 1046045-61-7 | FGH10019 is a novel and potentinhibitor of the sterol regulatory element-binding protein (SREBP) with IC50 of 1 μM. |
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V32445 | FT113 | 1630808-89-7 | FT113 is a potent and orally bioavailable fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. |
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V3595 | GSK2194069 | 1332331-08-4 | GSK2194069 is a novel, potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM in an assay detecting released CoA. |
|
V74018 | IPI-9119 | 1346564-56-4 | IPI-9119 is an orally bioactive, selective and irreversible FASN inhibitor (antagonist) with IC50 of 0.3 nM. |
|
V10528 | Lycorine | 476-28-8 | Lycorine is a naturally occurring alkaloid found in plants of the Amaryllidaceae family. |
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V4145 | PF-429242 dihydrochloride | 2248666-66-0 | PF429242 dihydrochloride is a novel, potent, reversible and competitiveS1P[sterol regulatory element-binding protein (SREBP) site 1 protease] inhibitor with anIC50of 170 nM. |
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V29487 | Praeruptorin B | 73069-28-0 | Praeruptorin B, a naturally occuring compoundfrom roots of Peucedanum praeruptorum Dunn,is a potent inhibitor of sterol regulatory element-binding proteins (SREBPs). |
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V74021 | SREBP/SCAP-IN-1 | 2763493-89-4 | SREBP/SCAP-IN-1 (compound 10b) is a selective SREBP/SCAP inhibitor. |
|
V74022 | SREBP/SCAP-IN-2 | 2763493-94-1 | SREBP/SCAP-IN-1(compound 13) is a selective SREBP/SCAP inhibitor. |
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