Galectin

Galectin

Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans.Galectins are typically divided into three groups based on their structural characteristics: (i) prototypical galectins (Galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), which are characterized by asingle CRD and can function as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), which has asingle CRD and a Galectins have recently been linked to important therapeutic factors that affect whether a variety of anticancer treatment modalities, such as chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies are effective or ineffective.

Galectin related products

Structure Cat No. Product Name CAS No. Product Description
V74909 DB21, Galectin-1 Antagonist 1623027-80-4
V76994 G3-C12 TFA
V74910 Galectin-3 antagonist 1 2921603-03-2
V74911 Galectin-3 antagonist 2 2921603-02-1
V74912 Galectin-3-IN-2 2883648-71-1
V79555 Galectin-3/galectin-8-IN-1
V79556 Galectin-3/galectin-8-IN-2
V80258 Galectin-8-IN-1
V74913 Galectin-8N-IN-1 2667628-25-1
V21523 GB1107 1978336-61-6 GB1107 (GB-1107) is a novel, potent, selective, orally bioavailable galectin-3 (GAL-3) inhibitor with anticancer activity.
V15975 TD-139 1450824-22-2 TD-139 is a novel and potent galectin-3 inhibitor with the potential for the treatment of idiopathic pulmonary fibrosis (IPF)
V74907 Thiodigalactoside (TDG) 51555-87-4
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