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Galectin

Galectin

Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans.Galectins are typically divided into three groups based on their structural characteristics: (i) prototypical galectins (Galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), which are characterized by asingle CRD and can function as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), which has asingle CRD and a Galectins have recently been linked to important therapeutic factors that affect whether a variety of anticancer treatment modalities, such as chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies are effective or ineffective.

Galectin related products

Structure Cat No. Product Name CAS No. Product Description
(2S)-Selvigaltin V86851 (2S)-Selvigaltin (2S)-Selvigaltin is the S-isomer of selvigaltin.
6Lac[6]Met V83485 6Lac[6]Met 1132892-04-6
DB21, Galectin-1 Antagonist V74909 DB21, Galectin-1 Antagonist 1623027-80-4 DB21, Galectin-1 Antagonist is a dibenzofuran-conjugated peptide mimetic that works as an allosteric inhibitor of galectin-1 (GAL1) binding to cell surface glycans.
G3-C12 TFA V76994 G3-C12 TFA G3-C12 (TFA) is a galectin-3 binding peptide with Kd of 88 nM and has anti-tumor activity.
Galectin-3 antagonist 1 V74910 Galectin-3 antagonist 1 2921603-03-2 Galectin-3 antagonist 1 (compound 15) is a potent and specific Galectin-3 (Gal-3) antagonist (inhibitor) with a Kd of 5.3 μM.
Galectin-3 antagonist 2 V74911 Galectin-3 antagonist 2 2921603-02-1 Galectin-3 is a β-galactoside-specific carbohydrate recognition protein (lectin) that has the ability to promote the migration of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and withstand drug treatment.
Galectin-3-IN-2 V74912 Galectin-3-IN-2 2883648-71-1 Galectin-3-IN-2 (Compound 9) is a potent multivalent galectin-3 (Gal-3; IC50=8.3 μM) inhibitor.
Galectin-3-IN-3 V86847 Galectin-3-IN-3 2491661-50-6 Galectin-3-IN-3 (compound 4) is an orally active and selective Gal-3 inhibitor with IC50 values of 11 nM and 84 nM for mGal-3 and hGal-3, respectively.
Galectin-3-IN-4 V86850 Galectin-3-IN-4 2496515-38-7 Galectin-3-IN-4 (compound 5) is a carboxamide analog.
Galectin-3-IN-5 V99835 Galectin-3-IN-5 Galectin-3-IN-5 (Compound 20) is an orally active galectin-3 (Gal-3) inhibitor with IC50 of 9.2 nM for hGal-3.
Galectin-3/galectin-8-IN-1 V79555 Galectin-3/galectin-8-IN-1 Galectin-3/galectin-8-IN-1 (Compound 53) is a dual galectin-3 and galectin-8 C-terminal domain inhibitor (antagonist) with K d values of 4.12 μM and 6.04 μM, respectively.
Galectin-3/galectin-8-IN-2 V79556 Galectin-3/galectin-8-IN-2 Galectin-3/galectin-8-IN-2 (Compound 57) is a dual galectin-3 and galectin-8 C-terminal domain inhibitor (antagonist) with Kds of 12.8 μM and 2.06 μM, respectively.
Galectin-4-IN-3 V86849 Galectin-4-IN-3 1044566-26-8 Galectin-4-IN-3 (Compound 11) is a galectin 4C inhibitor with Kd of 160 μM.
Galectin-8-IN-1 V80258 Galectin-8-IN-1 3028946-23-5 Galectin-8-IN-1 is a selective ligand of galectin-8N, with a Kd of 48 μM.
Galectin-8-IN-2 V83388 Galectin-8-IN-2 1044566-24-6
Galectin-8N-IN-1 V74913 Galectin-8N-IN-1 2667628-25-1 Galectin-8N-IN-1 (compound 19a) is a potent and specific galectin-8N inhibitor (antagonist) with a Kd of 1.8 μM.
Galectin-8N-IN-2 V99747 Galectin-8N-IN-2 Galectin-8N-IN-2 (Compound 2) is a potent and selective Galectin-8N inhibitor with a Ki value of 74 μM.
GB1107 V21523 GB1107 1978336-61-6 GB1107 (GB-1107) is a novel, potent, selective, orally bioavailable galectin-3 (GAL-3) inhibitor with anticancer activity.
GB1490 V85894 GB1490 2172866-22-5
GB1908 V86848 GB1908 GB1908 is a selective oral galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively.
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