Trace amine associated-receptors (TAARs) are a class of G protein-coupled receptors that were discovered in 2001.While some fish species express over 100 functional isoforms, humans only have six (TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9). It serves as the trace amines' endogenous receptor. Endogenous compounds known as trace amines are traditionally believed to include β-phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and certain of their metabolites.
The main olfactory system's chemosensory receptors are the primary function of all other TAARs, but TAAR 1 has been shown to be a novel modulator of dopaminergic, serotonergic, and glutamatergic activity in the brain. Furthermore, TAAR 1 has been found to be a novel therapeutic target for addiction, depression, and schizophrenia. Peripherally, TAAR1 controls the release of hormones induced by nutrition, indicating that it may be a new target for treating obesity and diabetes. TAAR1 may also control leukocyte activation and differentiation, which in turn controls immune responses.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V41800 | Ralmitaront (WHO-11130; RO-6889450; RG-7906) | 2133417-13-5 | Ralmitaront (WHO-11130; RO-6889450; RG-7906) is a novel and orally bioactive partial agonist of TAAR1 (trace amine-associated receptor 1) and a neuroleptic agent that maybe used for the treatment of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder, and negative symptoms. |
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V74519 | RO 5212773 (EPPTB) | 1110781-88-8 | Ro 5212773 (EPPTB) is a potent and specific (TAAR1) antagonist (Ki 0.9 nM for mouse TAAR1) without significant effects on other TAARs. |
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V74521 | ZH8651 (4-Bromophenylethylamine 1G) | 73918-56-6 | ZH8651 is an agonist of TAAR1 and can activate both Gs and Gq signaling pathways. |
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