DGK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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DGK

Diacylglycerol Kinase (DGK) regulates the equilibrium between phosphatidic acid (PA) and DAG. DAG is phorylated by DGK to produce PA. Ten mammalian DGK subtypes (-) that can be divided into five different types exist. Each subtype has its own tissue distribution. Among them, the production of DAG as a second messenger following stimulation of the T cell receptor is specifically regulated by DGK and DGK. However, in T cells, DGK is the predominant isoform. Certain DGK isoforms that are dysregulated cause DAG-activated PKC, attenuated insulin signaling, and dysregulated glucose metabolism. DGK participates in a variety of physiological processes, such as cell migration and proliferation, glucose uptake, immunity, and the development of neuronal networks.

DGK related products

Cat No.	Product Name	CAS No.	Product Description
V114696	(1R)-BMS-986408	2618418-11-2	(1R)-BMS-986408 is an orally effective dual DGK α/ζ inhibitor.
V32186	(5Z,2E)-CU-3	1815598-71-0	(5Z,2E)-CU-3is a novel, potent and selective diacylglycerol kinase alpha (DGKalpha) inhibitorwithanIC50valueof0.6 μM, attenuating cancer cell proliferation and simultaneously enhancing immune responses including anti-cancer immunity.
V109979	AHL-7160		AHL-7160 is a covalent DGKα inhibitor with dual functions: inhibiting enzyme activity (IC₅₀ ≈ 12 nM) and molecular glue-mediated degradation.
V113321	Alcudacigib TFA		Alcudacigib (compound 9) TFA is a DGKz inhibitor.
V73996	AMB639752	371210-26-3	AMB639752 is a potent DGKα inhibitor.
V73987	BAY 2965501	2732902-08-6	BAY 2965501 is a potent and specific diacylglycerol kinase zeta (DGKζ) inhibitor.
V51059	BAY-2965501		DGKzeta inhibitor
V74001	BMS-332	2407892-15-1	BMS-332 is a dual (bifunctional) inhibitor of DGKα/ζ lipokinase with IC50 of 0.005 μM (DGKα) and 0.001 μM (DGKζ) respectively.
V73995	BMS-496	2407854-31-1	BMS-496 is a dual (bifunctional) inhibitor of DGKα/ζ lipokinase with IC50 of 0.09 μM (DGKα) and 0.006 μM (DGKζ) respectively.
V73988	BMS-502	2407854-18-4	BMS-502 (Compound 22) is a potent dual (bifunctional) inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50s of 4.6 nM and 2.1 nM.
V73997	BMS-684	313552-29-3	BMS-684 is a selective DGKα inhibitor (antagonist) with IC50 of 15 nM.
V99706	BMS-986408	2618418-12-3	BMS-986408 is an oral dual DGK α/ζ inhibitor that restores T cell-mediated anti-tumor immunity by enhancing T cell signaling.
V73999	Cochlioquinone A (Luteoleersin)	32450-25-2	Cochlioquinone A is an ATP-competitive diacylglycerol kinase inhibitor (Ki= 3.1 μM).
V73989	DGK-IN-1	2407892-34-4	DGK-IN-1 is a T cell activator from patent WO2020006018A1, Example 25.
V116972	DGK-IN-11	3023735-36-3	DGK-IN-11 (compound 1) is a diacylglycerol kinase (DGK) inhibitor.
V117173	DGK-IN-12	3023735-35-2	DGK-IN-12 is a DGK inhibitor that can be used in cancer research.
V117149	DGK-IN-13	3023735-55-6	DGK-IN-13 is a DGK inhibitor that can be used in cancer research.
V104007	DGK-IN-8	3039488-69-9	DGK-IN-8 (Example 34) is a DGK inhibitor with IC50 ≤ 20 nM for DGKα and ζ.
V74000	DGKα&ζ-IN-1	2830643-06-4	DGKα&ζ-IN-1 (Compound II) is a DGK target inhibitor.
V117459	DGKα&ζ-IN-2	3039488-61-1	DGKα/ζ-IN-2 is a highly effective, orally active, and selective DGKα/ζ inhibitor with IC50 values of 23 nM (DGKα) and 1.2 nM (DGKζ).