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Glutathione Peroxidase

Glutathione Peroxidase

Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.

Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
 

Glutathione Peroxidase related products

Structure Cat No. Product Name CAS No. Product Description
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid V73802 (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid 771493-42-6 (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is an α-Glucosidase ) inhibitor (antagonist) with IC50 of 577.7 µM.
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) V73799 (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) 41607-20-9 (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 48.13 µM.
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid V73800 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 132282-70-3 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin extracted from Rubus ellipticus var.
2-Nitrophenyl aD-glucopyranoside V73786 2-Nitrophenyl aD-glucopyranoside 56193-44-3 2-Nitrophenyl aD-glucopyranoside is a beta-glucosidase substrate.
2-Nitrophenyl β-D-glucopyranoside V73808 2-Nitrophenyl β-D-glucopyranoside 2816-24-2 2-Nitrophenyl β-D-glucopyranoside is a substrate of β-glucosidase.
4-Methylumbelliferyl α-L-arabinofuranoside V73782 4-Methylumbelliferyl α-L-arabinofuranoside 77471-44-4 4-Methylumbelliferyl α-L-arabinofuranoside is a substrate for glycosidases.
4-Methylumbelliferyl β-D-Glucopyranoside V73777 4-Methylumbelliferyl β-D-Glucopyranoside 18997-57-4 4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorescent substrate for β-glucosidase and is used to measure β-glucosidase activity.
4-Nitrophenyl aD-glucopyranoside V73779 4-Nitrophenyl aD-glucopyranoside 3767-28-0 4-Nitrophenyl aD-glucopyranoside is a chromogenic substrate for α-glucosidase.
5-O-Methylgenistein (Isoprunetin) V73818 5-O-Methylgenistein (Isoprunetin) 4569-98-6 5-O-Mmethylgenistein (Isoprunetin) is an isoflavone that can be extracted from M.
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone V73814 6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone 1622982-59-5 6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC50= 185 μM), which can be extracted from Cassia seeds.
6-Prenylquercetin-3-Me ether V73813 6-Prenylquercetin-3-Me ether 151649-34-2 6-Prenylquercetin-3-Me ether is a naturally occurring compound that can be found in the leaves of G.uralensis.
6β-Hydroxyipolamiide V73804 6β-Hydroxyipolamiide 87797-84-0 6β-Hydroxyipolamiide can be extracted from the methanolic extract of S. jamaicensis leaves.
AZD-5904 V4241 AZD-5904 618913-30-7 AZD5904 is a novel,potent, orally bioavailable, irreversible inhibitor of human MPO (Myeloperoxidase) with an IC50 of 140 nM and with similar potency in mouse and rat.
Barbinervic acid V73161 Barbinervic acid 64199-78-6 Barbinervic acid is a glutaminase inhibitor (antagonist) with IC50 of 14 μM.
Bisabolone oxide A V73795 Bisabolone oxide A 22567-38-0 Bisabolone oxide A is an inhibitor (blocker/antagonist) of alpha-glucose.
Carpachromene V73793 Carpachromene 57498-96-1 Carpachromene is a potent α-glucosidase enzyme inhibitor.
Casuarictin V73774 Casuarictin 79786-00-8 Casuarictin is a potent and competitive α-glucosidase inhibitor (antagonist) with IC50 of 0.21 μg/mL.
Clervonafusp alfa (VAL-1221) V73790 Clervonafusp alfa (VAL-1221) 2145123-44-8 Clervonafusp alfa (VAL-1221) is a fusion protein targeting cytosolic and lysosomal glycogen.
Cyclophellitol aziridine V73789 Cyclophellitol aziridine 136861-97-7 Cyclophellitol aziridine is a cyclophenol analog and a potent β-glucosidase inhibitor.
EB-0150 V73807 EB-0150 2832824-40-3 EB-0150 is a potent inhibitor of ER α-glucosidase (α-Glu) I and II, with IC50s values of 0.73 and less than 0.0337 μM, respectively.
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