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Glutathione Peroxidase

Glutathione Peroxidase

Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.

Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
 

Glutathione Peroxidase related products

Structure Cat No. Product Name CAS No. Product Description
V118960 ML210-ansaFc ML210-ansaFc (compound III-13) is a covalent GPX4 inhibitor containing a ferrocene group (IC50 of 3.4 μM).
V117202 Myeloperoxidase, Human Neutrophil Human neutrophil myeloperoxidase is a type of peroxidase.
V120028 GPX4-IN-18 3016433-00-1 GPX4-IN-18 (compound 17) is a ferrocene-containing glutathione peroxidase 4 (GPX4) inhibitor.
V112477 GPX4-IN-20 GPX4-IN-20 is an Arctic flavin derivative and a GPX4 molecular gel degrader that induces ferroptosis by increasing lipid reactive oxygen species (ROS) levels and inhibiting glutathione (GSH) levels.
V116486 GPX4-IN-19 3102894-57-2 GPX4-IN-19 is a potent GPX4 inhibitor (IC50 = 0.311 μM) that covalently binds to the Sec 46 site of GPX4.
V116669 PROTAC GPX4 degrader-5 PROTAC GPX4 Degrader-5 (Compound N15) is a highly efficient and selective PROTAC GPX4 degrader (DC50 = 28 nM).
V118290 MB-Buf MB-Buf is a conjugate of methylene blue and bufotalin.
V118478 RSL3-NH2 3051815-39-2 RSL3-NH2 is a GPX4 inhibitor and ferroptosis inducer.
V116091 POI ligand-2 POI ligand-2 is a ligand for the GPX4 protein.
V116065 Asperilin 7044-35-1 Aspirin is an orally effective sesquiterpene lactone with a strong hydroxyl radical scavenging ability.
V115778 NAA-004 402934-69-4 NAA-004 (NM-004) is a novel azo compound composed of 5-aminosalicylic acid and 4-aminophenylacetic acid linked by an azo bond.
V111348 iMQT_020 2463893-46-9 iMQT_020 is a selective allosteric SLC1A5_var inhibitor.
V116224 POI ligand-2-NH-C10H20-NH-Boc POI ligand-2-NH-C10H20-NH-Boc is a target protein ligand-linker conjugate containing a GPX4 ligand and a PROTAC linker, which can recruit E3 ligases.
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid V73802 (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid 771493-42-6 (-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is an α-Glucosidase ) inhibitor (antagonist) with IC50 of 577.7 µM.
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) V73799 (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) 41607-20-9 (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 48.13 µM.
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid V73800 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 132282-70-3 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin extracted from Rubus ellipticus var.
(3S)-Butylphthalide V105638 (3S)-Butylphthalide 3413-15-8 (3S)-Butylphthalide is a tetrachlorophthalide that can be extracted from Dianthus chinensis.
2-Nitrophenyl aD-glucopyranoside V73786 2-Nitrophenyl aD-glucopyranoside 56193-44-3 2-Nitrophenyl aD-glucopyranoside is a beta-glucosidase substrate.
2-Nitrophenyl β-D-glucopyranoside V73808 2-Nitrophenyl β-D-glucopyranoside 2816-24-2 2-Nitrophenyl β-D-glucopyranoside is a substrate of β-glucosidase.
4-Methylumbelliferyl α-L-arabinofuranoside V73782 4-Methylumbelliferyl α-L-arabinofuranoside 77471-44-4 4-Methylumbelliferyl α-L-arabinofuranoside is a substrate for glycosidases.
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