Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73623 | (-)-(S)-Cibenzoline (Escibenzoline) | 103419-18-7 | (-)-(S)-Cibenzoline (Escibenzoline), the S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent. |
|
V73640 | (Rac)-AZD3839 | 1227163-56-5 | (Rac)-AZD3839 is an orally bioactive beta-amyloid precursor protease cleavage enzyme (BACE1) inhibitor (antagonist) with BBB (blood-brain barrier) permeability. |
|
V73622 | (rac)-Indapamide-d3 (indapamide d3) | 1217052-38-4 | (rac)-Indapamide-d3 is the deuterated racemate of Indapamide. |
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V73659 | 3-Chlorodiphenylamine | 101-17-7 | 3-Chlorodiphenylamine is a high-affinity myocardial Ca2+ sensitizer (Ca2+ sensitizer). |
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V73629 | 4-Aminopyridine-d4 | 26257-21-6 | 4-Aminopyridine-d4 is the deuterium labelled form of 4-Aminopyridine. |
|
V73589 | 5-Hydroxydecanoate sodium (5-Hydroxydecanoate sodium salt) | 71186-53-3 | 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 approximately 30 μM). |
|
V73606 | 8-Azido-ATP (8-Azidoadenosine 5'-triphosphate; 8-N3-ATP) | 53696-59-6 | 8-Azido-ATP is a photolytic nucleotide analog used for the identification of proteins such as DNA-dependent RNA polymerase. |
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V37830 | A2764 diHCl | 861038-72-4 | A2764 diHCl is a selective inhibitor of TRESK (K2P18.1) and has certain inhibitory activities on TREK-1 and TALK-1. |
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V2418 | A2793 | 88349-90-0 | A2793 inhibited TWIK-related acid-sensitive K+channel (TASK)-1 (100µM, 53.4% ± 13, 5%,n= 5). |
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V77708 | Aa1 toxin | Aa1 toxin, a neurotoxic peptide obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. | |
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V77712 | Aam-KTX | Aam-KTX is a Kv channel inhibitor (antagonist) with IC50s of 1.1 nM and >750 nM for Kv1.3 and Kv1.1, respectively. | |
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V77827 | ADWX 1 | ADWX 1 is a novel peptide that potently targets Kv1.3, with IC50 of 1.89 pM. | |
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V73643 | Agitoxin-2 | 168147-41-9 | Agitoxin-2 is a blocker of K+ channels, with IC50s of 201 pM and 144 pM for mKV1.3 and mKV1.1 respectively. |
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V77858 | Agitoxin-2 TFA | Agitoxin-2 TFA is a K+ channel blocker with IC50s of 201 pM and 144 pM for mKV1.3 and mKV1.1 respectively. | |
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V4822 | AM-92016 HCl | 133229-11-5 | AM-92016 HCl, the hydrochloride salt of AM-92016 (an oxypropanolamine analog of sotalol), is a novel, potent and specificIKinhibitor. |
|
V3861 | Amifampridine | 54-96-6 | Amifampridine (trade name: Firdapse; pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP) is an FDA approved drug used predominantly in the treatment of a number of rare muscle diseases such as Lambert-Eaton myasthenic syndrome (LEMS) in adults. |
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V3862 | Amifampridine phosphate | 446254-47-3 | Amifampridinephosphate (trade name: Firdapse; pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP) is the phosphate salt of Amifampridine, which is an FDA approved drug used mainly in the treatment of a number of rare muscle diseases such as Lambert-Eaton myasthenic syndrome (LEMS) in adults (It gained US approval in November 2018). |
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V1672 | Amiodarone HCl (NSC 85442) | 19774-82-4 | Amiodarone HCl(formerly NSC-85442; NSC85442;NSC 85442; Cordarone),the hydrochloride salt of amiodarone, is an antiarrhythmic drugused to treat and prevent an irregular heartbeat. |
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V77931 | AmmTX3 | AmmTX3 is a bioactive peptide toxin extracted from the venom of the scorpion Androctonus mauretanicus. | |
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V77932 | AmmTX3 TFA | AmmTX3 TFA is a bioactive peptide toxin extracted from the venom of the scorpion Androctonus mauretanicus. |
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