Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V73623 | (-)-(S)-Cibenzoline (Escibenzoline) | 103419-18-7 | (-)-(S)-Cibenzoline (Escibenzoline), the S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent. |
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V101758 | (E)-Azimilide | 1294552-65-0 | (E)-Azimilide is an isomer of azimilide, a class of antiarrhythmic compounds that inhibit the activity of I(Ks) and I(Kr). |
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V73640 | (Rac)-AZD3839 | 1227163-56-5 | (Rac)-AZD3839 is an orally bioactive beta-amyloid precursor protease cleavage enzyme (BACE1) inhibitor (antagonist) with BBB (blood-brain barrier) permeability. |
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V73622 | (rac)-Indapamide-d3 (indapamide d3) | 1217052-38-4 | (rac)-Indapamide-d3 is the deuterated racemate of Indapamide. |
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V1674 | TRAM-34 | 289905-88-0 | TRAM-34 (TRAM34;TRAM 34 Triarylmethane-34)is an inhibitor of Ca2+-activated K+ channel (IKCa1, KCa3.1) with important biological activity. |
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V73659 | 3-Chlorodiphenylamine | 101-17-7 | 3-Chlorodiphenylamine is a high-affinity myocardial Ca2+ sensitizer (Ca2+ sensitizer). |
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V73629 | 4-Aminopyridine-d4 | 26257-21-6 | 4-Aminopyridine-d4 is the deuterium labelled form of 4-Aminopyridine. |
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V102123 | 4-trans-Hydroxy-glibenclamide | 23155-00-2 | Rac-trans-4-hydroxyglyburide is the active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide. |
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V73589 | 5-Hydroxydecanoate sodium (5-Hydroxydecanoate sodium salt) | 71186-53-3 | 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 approximately 30 μM). |
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V101800 | 5Me3F4AP | 13958-85-5 | 5Me3F4AP is a potent potassium channel blocker with IC50 ranging from 220 μM to 693 μM when pH increases from 6.4 to 9.1. |
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V90294 | 6-Bnz-cAMP | 30275-80-0 | 6-Bnz-cAMP (N6-Benzoyl-cAMP) is a derivative of cyclic adenosine monophosphate (cAMP) and a potent bTREK-1 potassium channel inhibitor. |
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V73606 | 8-Azido-ATP (8-Azidoadenosine 5'-triphosphate; 8-N3-ATP) | 53696-59-6 | 8-Azido-ATP is a photolytic nucleotide analog used for the identification of proteins such as DNA-dependent RNA polymerase. |
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V86233 | 8-Azido-ATP trisodium (8-Azidoadenosine 5'-triphosphate trisodium; 8-N3-ATP trisodium) | ||
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V37830 | A2764 diHCl | 861038-72-4 | A2764 diHCl is a selective inhibitor of TRESK (K2P18.1) and has certain inhibitory activities on TREK-1 and TALK-1. |
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V2418 | A2793 | 88349-90-0 | A2793 inhibited TWIK-related acid-sensitive K+channel (TASK)-1 (100µM, 53.4% ± 13, 5%,n= 5). |
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V77708 | Aa1 toxin | Aa1 toxin, a neurotoxic peptide obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. | |
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V77712 | Aam-KTX | Aam-KTX is a Kv channel inhibitor (antagonist) with IC50s of 1.1 nM and >750 nM for Kv1.3 and Kv1.1, respectively. | |
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V77827 | ADWX 1 | ADWX 1 is a novel peptide that potently targets Kv1.3, with IC50 of 1.89 pM. | |
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V94056 | Aekatperone | Aekatperone is a reversible KATP channel inhibitor with IC50 of 9 μM. | |
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V73643 | Agitoxin-2 | 168147-41-9 | Agitoxin-2 is a blocker of K+ channels, with IC50s of 201 pM and 144 pM for mKV1.3 and mKV1.1 respectively. |