Steroid 5-reductase (5AR) is a membrane-bound protein that converts steroid hormones like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstenedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.
Sexual development disorders result from the inactivating mutations in 5R2. Prostate cancer (PC) and benign prostate hyperplasia (BPH) are both treated by controlling the 5AR, and 5AR inhibitors are frequently used to treat androgen-dependent benign or malignant prostatic diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V5245 | Phenprocoumon (Marcumar | 435-97-2 | Phenprocoumon(Marcumar),a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K, is a vitamin K reductase with an IC50 of 1 μM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
