Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin.A disulfide-linked oligomer of two alpha and two beta subunits makes up the receptor. The two insulin receptor isoforms, IR-A and IR-B, are present and expressed in various organs and tissues in varying amounts. The binding affinities of the two IR isoforms for insulin and the insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B, are comparable.
Controlling glucose homeostasis, regulating lipid, protein, and carbohydrate metabolism, and modifying levels of brain neurotransmitters are all important functions of the insulin receptor. Diabetes, cancer, and Alzheimer's disease are just a few of the illnesses that have been linked to insulin receptor dysfunction.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69526 | (Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) | 299898-52-5 | (Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is a potent, stable and specific full agonist of the human GIP receptor. |
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V85919 | (Pro3) GIP, human TFA ((Pro3) Gastric Inhibitory Peptide, human TFA) | ||
![[D-Ala2]-GIP (human)](http://www.invivochem.com/upload/1124/V69511.png)
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V69511 | [D-Ala2]-GIP (human) | 444073-04-5 | [D-Ala2]-GIP (human) is a GIP receptor agonist. |
![[Pro3]-GIP (Mouse)](http://www.invivochem.com/upload/1124/V77485.png)
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V77485 | [Pro3]-GIP (Mouse) | [Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50= 2.6 μM). | |
![[Tyr0] Gastric Inhibitory Peptide (23-42), human](http://www.invivochem.com/upload/1124/V69527.png)
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V69527 | [Tyr0] Gastric Inhibitory Peptide (23-42), human | 121765-67-1 | [Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak gastric acid secretion inhibitor and can also stimulate insulin secretion. |
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V69523 | Acetyl Gastric Inhibitory Peptide (human) (Human N-acetyl GIP) | 299898-33-2 | Acetyl Gastric Inhibitory Peptide (human) is a fatty acid-derived analog of a glucose-dependent insulinogenic peptide with improved antihyperglycemic and insulinogenic properties. |
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V77299 | Acetyl Gastric Inhibitory Peptide (human) (TFA) (Human N-acetyl GIP TFA) | Acetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid-derived analog of a glucose-dependent insulinogenic peptide with improved antihyperglycemic and insulinogenic properties. | |
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V69519 | Aganirsen | 1146887-67-3 | Aganirsen is an antisense oligonucleotide (25 nucleotides) that can inhibit insulin receptor substrate 1 (IRS-1). |
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V77856 | Aganirsen sodium | Aganirsen sodium is an antisense oligonucleotide (25 nucleotides) that can inhibit insulin receptor substrate 1 (IRS-1). | |
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V69514 | AVJ16 | 2775241-92-2 | AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA-binding protein IGF2BP1 and can inhibit the migration of H1299 cells that highly express endogenous IGF2BP1. |
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V88057 | D-Galactose pentaacetate | 25878-60-8 | D-Galactose pentaacetate can inhibit leucine-induced insulin release. |
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V69520 | DA-JC4 | 2315504-40-4 | DA-JC4 is a dual GLP-1/GIP receptor agonist (activator) that may be utilized to study neurological diseases and insulin signaling pathways. |
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V69529 | ERK Inhibitor II (Negative control) | 1177970-73-8 | ERK Inhibitor II (negative control (NC)) is a potent extracellular signal-regulated kinase (ERK) inhibitor. |
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V69530 | Gastric Inhibitory Polypeptide (1-30), porcine | 134875-67-5 | Gastric Inhibitory Polypeptide (1-30), porcine lacks the C-terminal 12 amino acid (AA) residues of natural gastric inhibitory polypeptide (GIP) and can enhance the release of insulin and somatostatin to exert bioactivity. |
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V76983 | GIP (1-30) amide, porcine TFA | GIP (1-30) amide, porcine TFA is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist/activator with the same affinity as native GIP (1-42). | |
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V69522 | GIP (1-30) amide,human | 198624-01-0 | GIP (1-30) amide,human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. |
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V79583 | GIP (1-30)-Myr | GIP (1-30)-Myr is Myr-modified GIP (1-30), a glucose-dependent insulinotropic polypeptide (GIP) fragment. | |
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V69512 | GIP (3-42), human | 1802086-25-4 | GIP (3-42), human works as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, regulating insulin secretion and the metabolic effects of GIP in vivo. |
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V106214 | GIP (mouse) | 181591-59-3 | |
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V76982 | GIP, human TFA (Gatric Inhibitory Peptide (GIP), human TFA) | GIP, human TFA, is a bioactive peptide hormone consisting of 42 amino acid (AA)s, which is a promoter of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. |
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