Insulin Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Insulin Receptor

Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin.A disulfide-linked oligomer of two alpha and two beta subunits makes up the receptor. The two insulin receptor isoforms, IR-A and IR-B, are present and expressed in various organs and tissues in varying amounts. The binding affinities of the two IR isoforms for insulin and the insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B, are comparable.

Controlling glucose homeostasis, regulating lipid, protein, and carbohydrate metabolism, and modifying levels of brain neurotransmitters are all important functions of the insulin receptor. Diabetes, cancer, and Alzheimer's disease are just a few of the illnesses that have been linked to insulin receptor dysfunction.

Insulin Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V69526	(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human)	299898-52-5	(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is a potent, stable and specific full agonist of the human GIP receptor.
V85919	(Pro3) GIP, human TFA ((Pro3) Gastric Inhibitory Peptide, human TFA)
V69511	[D-Ala2]-GIP (human)	444073-04-5	[D-Ala2]-GIP (human) is a GIP receptor agonist.
V77485	[Pro3]-GIP (Mouse)		[Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50= 2.6 μM).
V119691	[Pro3]-GIP (Rat)		[Pro3]-GIP (rat) is a selective partial agonist of the GIP receptor with a Ki value of 13 nM.
V69527	[Tyr0] Gastric Inhibitory Peptide (23-42), human	121765-67-1	[Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak gastric acid secretion inhibitor and can also stimulate insulin secretion.
V69523	Acetyl Gastric Inhibitory Peptide (human) (Human N-acetyl GIP)	299898-33-2	Acetyl Gastric Inhibitory Peptide (human) is a fatty acid-derived analog of a glucose-dependent insulinogenic peptide with improved antihyperglycemic and insulinogenic properties.
V77299	Acetyl Gastric Inhibitory Peptide (human) (TFA) (Human N-acetyl GIP TFA)		Acetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid-derived analog of a glucose-dependent insulinogenic peptide with improved antihyperglycemic and insulinogenic properties.
V128118	Acetyl Gastric Inhibitory Peptide (human) TFA		Acetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid derivative analog of a glucose-dependent insulinotropic peptide with enhanced hypoglycemic and insulin secretion-promoting properties.
V69519	Aganirsen	1146887-67-3	Aganirsen is an antisense oligonucleotide (25 nucleotides) that can inhibit insulin receptor substrate 1 (IRS-1).
V77856	Aganirsen sodium		Aganirsen sodium is an antisense oligonucleotide (25 nucleotides) that can inhibit insulin receptor substrate 1 (IRS-1).
V128390	Aganirsen sodium scrambled negative control		The Aganirsen sodium scrambled negative control is a negative control with the sequence of Aganirsen sodium scrambled.
V128418	AGT-182		AGT-182 is an anti-human insulin receptor antibody that can penetrate the blood-brain barrier and is conjugated with iduronic acid-2-sulfatase.
V128537	ALK-IN-24	2093414-37-8	ALK-IN-24 is an orally effective ALK inhibitor with an IC50 value of 1.7 nM.
V69514	AVJ16	2775241-92-2	AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA-binding protein IGF2BP1 and can inhibit the migration of H1299 cells that highly express endogenous IGF2BP1.
V129960	BDM71230		BDM71230 is an orally effective insulin-degrading enzyme (IDE) inducer with an EC50 value of 1.9 μM for human IDE.
V112389	Centpiperalone	22587-11-7	Semperaprone is an effective oral hypoglycemic agent.
V131785	cis-NVP-ADW742	475489-15-7	cis-NVP-ADW742 is the cis isomer of NVP-ADW742.
V88057	D-Galactose pentaacetate	25878-60-8	D-Galactose pentaacetate can inhibit leucine-induced insulin release.
V69520	DA-JC4	2315504-40-4	DA-JC4 is a dual GLP-1/GIP receptor agonist (activator) that may be utilized to study neurological diseases and insulin signaling pathways.