G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA or RNA secondary structures that are formed in guanine-rich sequences.The fact that G-quadruplex structures are widely distributed in the human genome's functional regions, including telomeres, ribosomal DNA (rDNA), transcription start sites, promoter regions, and untranslated regions of mRNA, suggests that they may be crucial in the regulation of a number of cellular processes. In the regulatory regions of microbes, such as bacteria, fungi, and viruses, G4s are also enriched and conserved.
Cancer and neurodegenerative diseases may be brought on by the erroneous formation of G4s on some genes. As a result, the therapeutic targets for these diseases are G4s in the genome. Small molecules, both natural and synthetic, are used to target G-quadruplexes specifically and have emerged as a new class of anticancer drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79018 | Antitumor agent-84 | Antitumor agent-84 (compound 21a) is a G-quadruplex (G4) ligand with the ability to stabilize different G4-DNA structures. | |
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V79009 | Antitumor agent-85 | Antitumor agent-85 is a G-quadruplex (G4) ligand with the ability to stabilize different G4-DNA structures. | |
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V54460 | Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | Carboxy pyridostatin trifluoroacetate salt displays high molecular specificity for RNA on DNA G4s. |
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V52175 | DIZ-3 | 2675490-72-7 | DIZ-3 is a selective multimeric G4 ligand based on a G4 ligand dimerization strategy. |
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V99643 | H2S probe 1 | H2S probe 1 (compound 1NND) is a nitrobenzoxadiazole (NBD) derivative with antitumor activity. | |
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V94578 | Nemorubicin hydrochloride | 108943-08-4 | Nemorubicin hydrochloride is a doxorubicin derivative with antitumor activity. |
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V98098 | OAF89 | OAF89 is a small molecule that can interact with G-quadruplexes (G4s) and dsDNA, with an IC50 of 1.07 μM in normal lung epithelial cells BEAS-2B. | |
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V32259 | Pyridostatin hydrochloride | 1781882-65-2 | Pyridostatin HCl (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
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V98081 | SJ26 | 1801288-67-4 | SJ26 is a Wnt1 inhibitor with anti-cancer activity that inhibits the expression of WNT1 and its mediated downstream signaling pathways in a G-quadruplex structure-dependent manner, thereby inhibiting the migration activity of cancer cells. |
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V4151 | Nemorubicin | 108852-90-0 | Nemorubicin (also known as PNU152243A; Methoxymorpholinyldoxorubicin; PNU 152243; PNU-152243A), an analog of doxorubicin, is a DNA-intercalator, topoisomerase and RNA synthesis inhibitor that was undergoing development for cancer treatment. |
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