Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that convert endogenous and exogenous aldehydes to their corresponding carboxylic acids. There are 19 isozymes in this protein superfamily, and most mammalian tissues exhibit constitutive activity for at least one of them. The ALDHs are crucial for cellular detoxification, defense against ultraviolet radiation-induced cellular damage, and amino acid metabolism.
By regulating retinoic acid signaling, the ALDH1A subfamily plays a crucial part in embryogenesis and development. Alcohol metabolism requires ALDH2, a crucial enzyme that oxidizes acetaldehyde. Lens and corneal crystallins, or ALDH1A1 and ALDH3A1, respectively, are crucial components of the cellular defense system against UV radiation-induced damage in ocular tissues. Numerous ALDH isozymes play a crucial role in oxidizing reactive aldehydes produced as a result of lipid peroxidation, aiding in the preservation of cellular homeostasis. Multiple human cancers have been reported to have elevated levels of ALDH isozymes, which are linked to cancer relapse. Inhibitors of the ALDH enzymes have been created as a direct result of their significant physiological and toxicological roles in the treatment of human diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V40672 | 4-Hydroxynonenal | 75899-68-2 | 4-Hydroxynonenal, anα,β unsaturated hydroxyalkenal, is a novel and potent inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) widely used as a marker of lipid peroxidation/oxidative/nitrosative stress biomarke. |
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V115668 | ABD-3001 | 350229-29-7 | ABD-3001 is an ALDH1 inhibitor. |
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V109204 | AD-9308 | 1804942-56-0 | AD-9308 is a highly selective, orally effective ALDH2 activator. |
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V10704 | Alda-1 | 349438-38-6 | Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist. |
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V73912 | ALDH (Aldehyde dehydrogenase (NAD(P))) | 9028-88-0 | ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes to the corresponding carboxylic acids, accompanied by the reduction of the cofactor NAD(P) to NAD(P)H, and is widely used in biochemical research. |
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V84702 | ALDH1A inhibitor 673A (ALDH1Ai 673A) | 109437-62-9 | |
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V110415 | ALDH1A1 modulator-1 | 620932-02-7 | ALDH1A1 regulator-1 is a regulator of ALDH1A1. |
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V87277 | ALDH1A1-IN-4 | 23982-86-7 | ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1 with IC50 of 0.32 μM. |
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V87276 | ALDH1A1-IN-5 | ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 values of 83, 45, and 43 µM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. | |
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V73914 | ALDH1A2-IN-1 | 2204229-64-9 | ALDH1A2-IN-1 is an active site-directed reversible inhibitor of ALDH1A2 (IC50=0.91 μM; Kd=0.26 μM). |
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V73919 | ALDH2 modulator 1 | 1629615-99-1 | ALDH2 modulator 1 is a potent orally bioactive aldehyde dehydrogenase-2 ALDH2 modulator. |
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V103078 | Aldi-2 | 499997-25-0 | Aldi-2 is a potent and specific covalent inhibitor of aldehyde dehydrogenase (ALDH) with IC50 of 2.5 μM, 6.4 μM and 1.9 μM for ALDH1A1, ALDH2 and ALDH3A1, respectively. |
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V37860 | CM10 | 692269-09-3 | CM10 is a potent and specific aldehyde dehydrogenase 1A (ALDH1A) family inhibitor (antagonist) with IC50s of 1700, 740 and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3 respectively. |
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V73913 | CM121 | 2204230-40-8 | CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM; Kd=1.1 μM). |
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V114644 | CP-470711 | 300548-99-6 | CP-470711 is an orally effective, potent, and selective sorbitol dehydrogenase (SDH) inhibitor with an IC50 value of 10 nM for human SDH and 17 nM for rat SDH. |
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V84349 | FSI-TN42 (N42) | 2445840-25-3 | |
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V73917 | IGUANA-1 | 2756014-25-0 | IGUANA-1 is a potent inhibitor of ALDH1B1, a mitochondrial enzyme that promotes colorectal and pancreatic cancer. |
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V73915 | IGUANA-1 free base (STL5-T-0057) | 2756014-24-9 | IGUANA-1 free base (STL5-T-0057) is a selective inhibitor of ALDH1 B1 with IC50 of 30 nM. |
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V103961 | KOTX1 | 1788963-83-6 | KOTX1 is an oral, potent and selective ALDH1A3 inhibitor. |
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V116820 | Lefelsiran | 2765645-87-0 | Lefelsiran is a small interfering RNA that targets ALDH2 and has been used in research on alcohol use disorder. |
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