ALDH

ALDH

Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that convert endogenous and exogenous aldehydes to their corresponding carboxylic acids. There are 19 isozymes in this protein superfamily, and most mammalian tissues exhibit constitutive activity for at least one of them. The ALDHs are crucial for cellular detoxification, defense against ultraviolet radiation-induced cellular damage, and amino acid metabolism.

By regulating retinoic acid signaling, the ALDH1A subfamily plays a crucial part in embryogenesis and development. Alcohol metabolism requires ALDH2, a crucial enzyme that oxidizes acetaldehyde. Lens and corneal crystallins, or ALDH1A1 and ALDH3A1, respectively, are crucial components of the cellular defense system against UV radiation-induced damage in ocular tissues. Numerous ALDH isozymes play a crucial role in oxidizing reactive aldehydes produced as a result of lipid peroxidation, aiding in the preservation of cellular homeostasis. Multiple human cancers have been reported to have elevated levels of ALDH isozymes, which are linked to cancer relapse. Inhibitors of the ALDH enzymes have been created as a direct result of their significant physiological and toxicological roles in the treatment of human diseases.

ALDH related products

Structure Cat No. Product Name CAS No. Product Description
V40672 4-Hydroxynonenal 75899-68-2 4-Hydroxynonenal, anα,β unsaturated hydroxyalkenal, is a novel and potent inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) widely used as a marker of lipid peroxidation/oxidative/nitrosative stress biomarke.
V10704 Alda-1 349438-38-6 Alda-1 is a potent and selective Aldehyde Dehydrogenase-2 Agonist.
V73912 ALDH (Aldehyde dehydrogenase (NAD(P))) 9028-88-0 ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes to the corresponding carboxylic acids, accompanied by the reduction of the cofactor NAD(P) to NAD(P)H, and is widely used in biochemical research.
V84702 ALDH1A inhibitor 673A (ALDH1Ai 673A) 109437-62-9
V73914 ALDH1A2-IN-1 2204229-64-9 ALDH1A2-IN-1 is an active site-directed reversible inhibitor of ALDH1A2 (IC50=0.91 μM; Kd=0.26 μM).
V73919 ALDH2 modulator 1 1629615-99-1 ALDH2 modulator 1 is a potent orally bioactive aldehyde dehydrogenase-2 ALDH2 modulator.
V37860 CM10 692269-09-3 CM10 is a potent and specific aldehyde dehydrogenase 1A (ALDH1A) family inhibitor (antagonist) with IC50s of 1700, 740 and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3 respectively.
V73913 CM121 2204230-40-8 CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM; Kd=1.1 μM).
V84349 FSI-TN42 (N42) 2445840-25-3
V73917 IGUANA-1 2756014-25-0 IGUANA-1 is a potent inhibitor of ALDH1B1, a mitochondrial enzyme that promotes colorectal and pancreatic cancer.
V73915 IGUANA-1 free base (STL5-T-0057) 2756014-24-9 IGUANA-1 free base (STL5-T-0057) is a selective inhibitor of ALDH1 B1 with IC50 of 30 nM.
V73918 NCT-501 hydrochloride 2080306-22-3 NCT-501 HCl is an effective aldehyde dehydrogenase 1A1 (ALDH1A1) selective inhibitor of theophylline type.
V73916 Win 18446 1477-57-2 Win 18446 is an orally bioactive inhibitor of the testis-specific enzyme ALDH1a2 with IC50 of 0.3 μM.
V73911 YG1702 724737-08-0 YG1702 is a potent specific inhibitor of ALDH18A1.
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