The role of tau as a microtubule-associated protein in neurons is well established. They play major roles in preserving the stability of microtubules in axons and are widely distributed in central nervous system (CNS) neurons. However, in a variety of neurodegenerative disorders collectively known as tauopathies, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70072 | (R)-TTBK1-IN-1 | 2735015-59-3 | TTBK1-IN-1 is a specific, brain-penetrating inhibitor of tau tubulin kinase 1 (TTBK1). |
|
V70076 | (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) | 2022956-55-2 | (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) is a bioactive peptide discovered by peptide screening. |
|
V70090 | (Ser(PO3H2)396,404)-Tau Peptide (379-408) | 2022956-60-9 | (Ser(PO3H2)396,404)-Tau Peptide (379-408) is a bioactive peptide discovered by peptide screening. |
|
V70099 | (Thr(PO3H2)231)-Tau Peptide (225-237) | 1670270-09-3 | (Thr(PO3H2)231)-Tau Peptide (225-237) is a fragment of the tau peptide. |
|
V70107 | Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 | 2858785-68-7 | Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, nontoxic to nerve cells, and can selectively inhibit tau fibrosis. |
|
V70087 | Acetyl-PHF5 amide | 1190970-24-1 | Acetyl-PHF5 amide is an amyloid tau peptide. |
|
V77297 | Acetyl-PHF6 amide TFA (AcPHF6 TFA; Ac-VQIVYK-NH2 TFA) | Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau-derived hexapeptide. | |
|
V70096 | Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) | 2022956-56-3 | Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) is a bioactive peptide discovered by peptide screening. |
|
V114571 | ACI-3024 | 2361566-66-5 | ACI-3024 is an orally effective and highly selective Tau protein aggregation inhibitor. |
|
V70068 | ASN90 | 1884154-02-2 | ASN90 is an orally bioactive and specific O-GlcNAcase (OGA) enzyme inhibitor (antagonist) with IC50 of 10.2 nM. |
|
V110342 | Aβ/tau aggregation-IN-4 | 3105860-83-8 | Aβ/tau aggregation inhibitor-IN-4 (compound D21) is an Aβ/tau aggregation inhibitor. |
|
V70073 | BSc3094 | 946857-84-7 | BSc3094 is a Tau aggregation inhibitor. |
|
V119907 | CHIPOpt | CHIPOpt is a peptide that belongs to the ortho-heterogeneous CHIP TPR domain inhibitors, with a Kd value of approximately 16 nM. | |
|
V70094 | CNS-11 | 445218-34-8 | CNS-11 is a compound that breaks down tau fibrils. |
|
V94860 | D-687 | 2276762-06-0 | D-687 is an inhibitor of Tau and Aβ. |
|
V94870 | D-688 | 2276762-07-1 | D-688 is an inhibitor of Tau and Aβ. |
|
V120380 | Diranersen scramble control | IONIS-MAPTRx (sodium) is a scrambled version of the IONIS-MAPTRx sodium sequence. | |
|
V109418 | Dopegal | 13023-73-9 | Dopamine is a metabolite of norepinephrine. |
|
V106432 | Etalanetug | Etalanetug is an IgG1κ humanized antibody against MAPT. | |
|
V80072 | GSK-3β inhibitor 15 | GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50= 3.4 nM). |
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