The role of tau as a microtubule-associated protein in neurons is well established. They play major roles in preserving the stability of microtubules in axons and are widely distributed in central nervous system (CNS) neurons. However, in a variety of neurodegenerative disorders collectively known as tauopathies, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70072 | (R)-TTBK1-IN-1 | 2735015-59-3 | TTBK1-IN-1 is a specific, brain-penetrating inhibitor of tau tubulin kinase 1 (TTBK1). |
|
V70076 | (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) | 2022956-55-2 | (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) is a bioactive peptide discovered by peptide screening. |
|
V70090 | (Ser(PO3H2)396,404)-Tau Peptide (379-408) | 2022956-60-9 | (Ser(PO3H2)396,404)-Tau Peptide (379-408) is a bioactive peptide discovered by peptide screening. |
|
V70099 | (Thr(PO3H2)231)-Tau Peptide (225-237) | 1670270-09-3 | (Thr(PO3H2)231)-Tau Peptide (225-237) is a fragment of the tau peptide. |
|
V70107 | Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 | 2858785-68-7 | Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, nontoxic to nerve cells, and can selectively inhibit tau fibrosis. |
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V70087 | Acetyl-PHF5 amide | 1190970-24-1 | Acetyl-PHF5 amide is an amyloid tau peptide. |
|
V77297 | Acetyl-PHF6 amide TFA (AcPHF6 TFA; Ac-VQIVYK-NH2 TFA) | Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau-derived hexapeptide. | |
|
V70096 | Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) | 2022956-56-3 | Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) is a bioactive peptide discovered by peptide screening. |
|
V70068 | ASN90 | 1884154-02-2 | ASN90 is an orally bioactive and specific O-GlcNAcase (OGA) enzyme inhibitor (antagonist) with IC50 of 10.2 nM. |
|
V70067 | Bepranemab (UCB 0107) | 2244960-75-4 | Bepranemab (UCB 0107) is a humanized, full-length IgG4 monoclonal antibody (mAb) that binds to the central tau epitope (amino acid (AA)s 235-250). |
|
V70073 | BSc3094 | 946857-84-7 | BSc3094 is a Tau aggregation inhibitor. |
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V70094 | CNS-11 | 445218-34-8 | CNS-11 is a compound that breaks down tau fibrils. |
|
V70065 | Gosuranemab (BMS-986168; IPN007; BIIB092) | 1788032-39-2 | Gosuranemab (BMS-986168) is a humanized IgG4 anti-tau monoclonal antibody (mAb). |
|
V80072 | GSK-3β inhibitor 15 | GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50= 3.4 nM). | |
|
V70088 | hBChE-IN-1 | 1776948-12-9 | hBChE-IN-1 (compound 4) is a quinolyl analogue that is a potent inhibitor of hBChE (IC50=7 nM) and has high selectivity over hAChE. |
|
V70074 | IONIS-MAPTRx (BIIB080; ISIS 814907) | 2857842-32-9 | IONIS-MAPTRx (BIIB080) is the first Tau-reducing antisense oligonucleotide (ASO). |
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V70069 | JG-23 | 2640819-75-4 | JG-23 is a 4-chloromodified analog that promotes t-tau degradation. |
|
V70066 | MG-2119 | 1065500-40-4 | MG-2119 is a potent monomeric tau and α-syn aggregation inhibitor. |
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V76770 | Microtubule-associated protein tau (26-44) | Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and a carboxyl group attached to lysine. | |
|
V70082 | Posdinemab | 2517973-04-3 | Posdinemab is a humanized IgG1κ antibody targeting microtubule-associated protein tau (MAPT). |
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