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Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. Four AR subtypes have so far been cloned and found in various tissues. When exposed to agonists, these receptors exhibit unique localization, signal transduction pathways, and modes of regulation. The capacity of some Adenosine receptors to act as sensors of cellular oxidative stress, which is transmitted by transcription factors like NF-B to control the expression of ARs, is one of their key characteristics. We'll look at the role of adenosine receptors in the control of healthy and unhealthy processes, including sleep, the growth of cancer, and the prevention of hearing loss.

Adenosine Receptor related products

Structure Cat No. Product Name CAS No. Product Description
1-Bromo-6-chlorohexane V81844 1-Bromo-6-chlorohexane 6294-17-3 1-Bromo-6-chlorohexane is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTAC.
2-Chloro-3-deazaadenosine V92176 2-Chloro-3-deazaadenosine 40656-71-1 2-Chloro-3-deazaadenosine is an agonist of adenosine receptors with Ki values of 0.3, 0.08, 25.5 and 1.9 μM for A1, A2A, A2B and A3 receptors, respectively.
2-Hexynyl-5′-N-ethylcarboxamidoadenosine V101276 2-Hexynyl-5′-N-ethylcarboxamidoadenosine 141018-30-6 2-Hexynyl-5′-N-ethylamide adenosine (HENECA) is a selective A2A adenosine receptor agonist.
5 -乙基甲酰氨基腺苷 V30762 5'-N-Ethylcarboxamidoadenosine 35920-39-9 NECA (5'-N-Ethylcarboxamidoadenosine) is a novel and potent adenosine receptor agonist with Ki values of 6.2, 14, and 20 nM for human A3, A1 and A2A receptors, respectively, and an EC50 of 2.4 μM for human A2B.
A1/A3 AR antagonist 1 V75274 A1/A3 AR antagonist 1 312929-49-0 A1/A3 AR antagonist 1 (compound 10) is a potent dual antagonist of adenylate 1 (A1) and adenylate 3 (A3) receptors, with Ki for human A1, human A3 and rat A1 respectively.
A1/A3 AR antagonist 3 V75268 A1/A3 AR antagonist 3 2665804-57-7 A1/A3 AR antagonist 3 is a dual A1R/A3R antagonist (inhibitor) with high affinity in the low micromolar to low nanomolar range.
A1AR antagonist 1 V75271 A1AR antagonist 1 2760128-99-0 A1AR antagonist 2 (compound 18g) is a potent and specific A1 adenosine receptor antagonist (inhibitor) with Ki of 2.08, 6.91 and 31.2 nM for hA1, hA2A and hA2B respectively.
A2A receptor antagonist 2 V51754 A2A receptor antagonist 2 2767206-20-0 A2A receptor antagonist 2 (compound 57) is a potent and selective adenosine A2A receptor antagonist (inhibitor) with IC50 of 8.3 nM.
A2AAR antagonist 2 V80161 A2AAR antagonist 2 3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity.
A2AR-antagonist-1 V51753 A2AR-antagonist-1 2922920-71-4 A2AR-antagonist-1 (compound 38) is a potent cervical adenylate A2A receptor (A2AR) clamp antagonist (IC50=29 nM).
A2aR拮抗剂Ciforadenant V3272 Ciforadenant (CPI-444; V81444) 1202402-40-1 Ciforadenant (formerly known as CPI-444; V-81444)is a potent, selective and orally bioactive small molecule inhibitor of the adenosine-A2a receptor(A2AR) on T-lymphocytes with anticancer and immunomodulatory activities and the potential to be used in cancer immunotherapy.
A2A受体拮抗剂1 V3128 A2A receptor antagonist 1 443103-97-7 A2A receptor antagonist 1 is a novel and potent antagonist of the adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.
A2B receptor antagonist 2 V75263 A2B receptor antagonist 2 784-90-7 A2B receptor antagonist 2 (compound 18) is an antagonist of the adenosine receptor A2B, with Kis of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively.
A3AR agonist 1 V78476 A3AR agonist 1 A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM).
A3AR agonist 2 V77938 A3AR agonist 2 A3AR agonist 2 (Compound 19) is a selective A3AR agonist (Ki: 22.1 nM).
A3AR agonist 4 V92167 A3AR agonist 4 3032475-23-0 A3AR agonist 4 is a A3 adenosine receptor (A3AR) agonist (Ki 1.24 nM for hA3AR).
A3AR antagonist 2 V75278 A3AR antagonist 2 1144161-05-6 A3AR antagonist 2 (compound 18) is a potent human A3 adenosine receptor blocker (antagonist) with Ki of 4.54 nM.
A3AR antagonist 3 V83599 A3AR antagonist 3 863202-33-9
A3AR antagonist 5 V96936 A3AR antagonist 5 333436-43-4 A3AR antagonist 5 (compound 16) is a selective antagonist of human adenosine A3 receptor with an affinity pC of 4.542 μM.
A3AR modulator 1 V79210 A3AR modulator 1 A3AR modulator 1 (MRS8054) is an orally bioactive A3AR (Adenosine Receptor) PAM (positive allosteric modulator).
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