Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. Four AR subtypes have so far been cloned and found in various tissues. When exposed to agonists, these receptors exhibit unique localization, signal transduction pathways, and modes of regulation. The capacity of some Adenosine receptors to act as sensors of cellular oxidative stress, which is transmitted by transcription factors like NF-B to control the expression of ARs, is one of their key characteristics. We'll look at the role of adenosine receptors in the control of healthy and unhealthy processes, including sleep, the growth of cancer, and the prevention of hearing loss.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81844 | 1-Bromo-6-chlorohexane | 6294-17-3 | 1-Bromo-6-chlorohexane is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTAC. |
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V30762 | 5'-N-Ethylcarboxamidoadenosine | 35920-39-9 | NECA (5'-N-Ethylcarboxamidoadenosine) is a novel and potent adenosine receptor agonist with Ki values of 6.2, 14, and 20 nM for human A3, A1 and A2A receptors, respectively, and an EC50 of 2.4 μM for human A2B. |
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V75274 | A1/A3 AR antagonist 1 | 312929-49-0 | A1/A3 AR antagonist 1 (compound 10) is a potent dual antagonist of adenylate 1 (A1) and adenylate 3 (A3) receptors, with Ki for human A1, human A3 and rat A1 respectively. |
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V75268 | A1/A3 AR antagonist 3 | 2665804-57-7 | A1/A3 AR antagonist 3 is a dual A1R/A3R antagonist (inhibitor) with high affinity in the low micromolar to low nanomolar range. |
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V75271 | A1AR antagonist 1 | 2760128-99-0 | A1AR antagonist 2 (compound 18g) is a potent and specific A1 adenosine receptor antagonist (inhibitor) with Ki of 2.08, 6.91 and 31.2 nM for hA1, hA2A and hA2B respectively. |
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V3128 | A2A receptor antagonist 1 | 443103-97-7 | A2A receptor antagonist 1 is a novel and potent antagonist of the adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively. |
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V51754 | A2A receptor antagonist 2 | 2767206-20-0 | A2A receptor antagonist 2 (compound 57) is a potent and selective adenosine A2A receptor antagonist (inhibitor) with IC50 of 8.3 nM. |
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V80161 | A2AAR antagonist 2 | 3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity. | |
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V51753 | A2AR-antagonist-1 | 2922920-71-4 | A2AR-antagonist-1 (compound 38) is a potent cervical adenylate A2A receptor (A2AR) clamp antagonist (IC50=29 nM). |
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V75263 | A2B receptor antagonist 2 | 784-90-7 | A2B receptor antagonist 2 (compound 18) is an antagonist of the adenosine receptor A2B, with Kis of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively. |
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V78476 | A3AR agonist 1 | A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM). | |
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V77938 | A3AR agonist 2 | A3AR agonist 2 (Compound 19) is a selective A3AR agonist (Ki: 22.1 nM). | |
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V75278 | A3AR antagonist 2 | 1144161-05-6 | A3AR antagonist 2 (compound 18) is a potent human A3 adenosine receptor blocker (antagonist) with Ki of 4.54 nM. |
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V79210 | A3AR modulator 1 | A3AR modulator 1 (MRS8054) is an orally bioactive A3AR (Adenosine Receptor) PAM (positive allosteric modulator). | |
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V3126 | Acefylline | 652-37-9 | Acefylline (also known as Theophylline-7-acetic acid and Theophyllineacetic acid), is an antagonist of theadenosine receptor and an activator of the peptidylarginine deiminase (PAD). |
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V10332 | Adenosine | 58-61-7 | Adenosine is an endogenous nucleoside consisting of an adenine attached via a β-N₉-glycosidic bond to a ribose. |
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V75275 | Adenosine 5'-monophosphate disodium (5'-Adenine nucleotide disodium salt (5'-AMP-NA2)) | 4578-31-8 | Adenosine 5'-monophosphate disodium is an orally bioactive purine nucleotide involved in ATP metabolism. |
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V51755 | Adenosine receptor antagonist 1 | 2682930-40-9 | Adenosine receptor antagonist 1 A2aR-selective antagonist that is 14 times more selective for A2aR than A2bR with an IC50 of 0.29 nM. |
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V75269 | Adenosine receptor antagonist 4 | 133240-06-9 | Adenosine receptor antagonist 4 (compound 2) is an adenosine A1 receptor antagonist (inhibitor) with a Ki of 101 nM for the human A1 receptor. |
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V3437 | BAY-545 | 1699717-32-2 | BAY-545 is a novel, potent and selective antagonist of A2B adenosine receptor with an IC50 of 59 nM. |
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